Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesaSarg.) extracts in cardiovascular diseases

Mengkai Lu, Lei Zhang, Jinyuan Pan, Huishan Shi, Muxin Zhang and Chao Li

Food Funct., 2023, 14, 5870
DOI: 10.1039/D3FO01688A

Study on Chemical Constituents of the Enriched Extracts of Erigeron multiradiatus and Anti-thrombotic Effect on Zebrafish

Li Li, Wenfang Jin, Yue Wang, Li Yang and Zhi-Feng Zhang

Pharmacognosy Magazine, 2023, 19, 638
DOI: 10.1177/09731296231184536

Detection of active vasodilatory compounds from hawthorn: Screening and determination of mechanism of action

Magdalena Šajnová, Ganesh Dussa, Patrícia Harčárová, Zuzana Lomozová, Milan Pour, Přemysl Mladěnka and Jana Pourová

Fitoterapia, 2026, 190, 107167
DOI: 10.1016/j.fitote.2026.107167

Bioactive Compounds in Hawthorn Leaves (Crataegus spp.)—Extraction, Functionality, and Future Perspectives: From Waste to Wealth

Akerke Kulaipbekova, Zhanar Nabiyeva, Elmira Assembayeva, Fuhang Song, Yufang Su, Kairat Bekbayev, Xun Zhu and Nasi Ai

Agriculture, 2026, 16, 363
DOI: 10.3390/agriculture16030363

The Nutritional and Bioactive Components, Potential Health Function and Comprehensive Utilization of Hawthorn: A Review

Wenteng Yang, Quanhong Gao, Kun Ran, Mingyue Jiao, Xiaodan Fu, Zhenlin Han, Chao Liu and Ningyang Li

Food Frontiers, 2025, 6, 2108
DOI: 10.1002/fft2.70073

Food Applications and Potential Health Benefits of Hawthorn

Juan Zhang, Xiaoyun Chai, Fenglan Zhao, Guige Hou and Qingguo Meng

Foods, 2022, 11, 2861
DOI: 10.3390/foods11182861

An integrated and rapid evaluation of Curcumae Radix from different botanical origins based on chemical components, antiplatelet aggregation effect and Fourier transform near-infrared spectroscopy

Meng Wang, Tingting Hu, Yuhang Li, Rui Wang, Yudie Xu, Yabo Shi, Huangjin Tong, Mengting Yu, Yuwen Qin, Xi Mei, Lianlin Su, Chunqin Mao, Tulin Lu, Lin Li, De Ji and Chengxi Jiang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 324, 124992
DOI: 10.1016/j.saa.2024.124992

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

Shilin Chen, Zheng Li, Sanyin Zhang, Yuxin Zhou, Xiaohe Xiao, Pengdi Cui, Binjie Xu, Qinghe Zhao, Shasha Kong and Yuntao Dai

Acta Pharmaceutica Sinica B, 2022, 12, 4075
DOI: 10.1016/j.apsb.2022.08.025

COMPONENT COMPOSITION AND BIOLOGICAL ACTIVITY OF CRATAEGUS PINNATIFIDA (ROSACEAE) (REVIEW)

Andrey L'vovich Budantsev, Lidiya Markovna Belenovskaya and Natal'ya Valentinovna Bityukova

JCPRM, 2020, 31
DOI: 10.14258/jcprm.2020046612

Recent development in zebrafish model for bioactivity and safety evaluation of natural products

Fang-Jun Lin, Hang Li, Ding-Tao Wu, Qi-Guo Zhuang, Hua-Bin Li, Fang Geng and Ren-You Gan

Critical Reviews in Food Science and Nutrition, 2022, 62, 8646
DOI: 10.1080/10408398.2021.1931023

Chemical constituents from Dracocephalum moldavica L. and their chemotaxonomic significance

Jiaming Wang, Jinfeng Sun, Mengjie Wang, Huiqiong Cui, Wei Zhou and Gao Li

Biochemical Systematics and Ecology, 2022, 102, 104422
DOI: 10.1016/j.bse.2022.104422

Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases

Samir K. Beura, Rishika Dhapola, Abhishek R. Panigrahi, Pooja Yadav, Reetesh Kumar, Dibbanti H. Reddy and Sunil K. Singh

Medicinal Research Reviews, 2023, 43, 1835
DOI: 10.1002/med.21965

Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice

Xufeng Bai, Shuwen Wang, Limei Shu, Qingyu Cao, Huiming Hu, Yanchen Zhu and Chen Chen

Journal of Ethnopharmacology, 2024, 327, 118006
DOI: 10.1016/j.jep.2024.118006

Recent advances in the extraction, purification and analytical techniques for flavonoids from plants: Taking hawthorn as an example

Zhe Han, Chunfeng Li and Guiyan Liu

Journal of Food Composition and Analysis, 2025, 141, 107372
DOI: 10.1016/j.jfca.2025.107372

Pimpinellin Inhibits Collagen-induced Platelet Aggregation and Activation Through Inhibiting Granule Secretion and PI3K/Akt Pathway

Gang Liu, Zhaowei Yuan, Xiaoyun Tian, Xiuqin Xiong, Fang Guo, Zihan Lin and Zhen Qin

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.706363

An Interpretable Screening Approach Derived Through XGBoost Regression for the Discovery of Hypolipidemic Contributors in Chinese Hawthorn Leaf and its Counterfeit Malus Doumeri Leaf

Zhen Li, Yuan Du, Chen Ding, Pufan Yang, Lin Wang and Yan Zhao

Plant Foods Hum Nutr, 2024, 79, 209
DOI: 10.1007/s11130-024-01148-z

Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6

Diego Méndez, Félix A. Urra, Juan Pablo Millas-Vargas, Marcelo Alarcón, Julio Rodríguez-Lavado, Iván Palomo, Andrés Trostchansky, Ramiro Araya-Maturana and Eduardo Fuentes

European Journal of Medicinal Chemistry, 2020, 192, 112187
DOI: 10.1016/j.ejmech.2020.112187

Bioassay-guided identification of antithrombotic compounds from Cnidoscolus aconitifolius (Mill.) I. M. Jhonst.: molecular docking, bioavailability, and toxicity prediction

Juan Pablo Quintal Martínez, Irma Guadalupe Quintal Ortiz, Ligia Gabriela Alonso Salomón, Karlina García-Sosa, Luis Manuel Peña Rodríguez, José Antonio Guerrero Analco, Juan Luis Monribot Villanueva, Abraham Marcelino Vidal Limón and Maira Rubi Segura Campos

Journal of Biomolecular Structure and Dynamics, 2024, 42, 1692
DOI: 10.1080/07391102.2023.2214214

The Protective Effect of Crataegus aronia Against High-Fat Diet-Induced Vascular Inflammation in Rats Entails Inhibition of the NLRP-3 Inflammasome Pathway

Abdullah S. Shatoor and Suliman Al Humayed

Cardiovasc Toxicol, 2020, 20, 82
DOI: 10.1007/s12012-019-09534-9

Effect of Shan Zha (Hawthorn or Crataegus) on gastrointestinal cancer: A network pharmacology and molecular docking study

Jing Yang, Jialin Gu, Ying Shen, Ling Cao, Hong Zhou and Wei Zhu

Cancer Pathogenesis and Therapy, 2023, 1, 229
DOI: 10.1016/j.cpt.2023.02.001

Current Perspective and Mechanistic Insights on Bioactive Plant Secondary Metabolites for the Prevention and Treatment of Cardiovascular Diseases

Jyotika Grewal, Vijay Kumar, Yashika Gandhi, Hemant Rawat, Ravindra Singh, Arjun Singh, Ch. V. Narasimhaji, Rabinarayan Acharya and Sujeet K Mishra

CHDDT, 2023, 23, 157
DOI: 10.2174/011871529X262371231009132426

Analysis of Adverse Reactions Associated with the Use of Crataegus-Containing Herbal Products

Herman J. Woerdenbag, Melissa Ursidae, Corine Ekhart, Martina Schmidt, Annabella Vitalone and Florence P. A. M. van Hunsel

Pharmaceuticals, 2024, 17, 1490
DOI: 10.3390/ph17111490

Weed Suppression and Molecular Mechanisms of Isochlorogenic Acid A Isolated from Artemisia argyi Extract via an Activity-Guided Method

Le Chen, Jinxin Li, Yunyun Zhu, Tingting Zhao, Lujuan Guo, Liping Kang, Jinqian Yu, Hongzhi Du and Dahui Liu

J. Agric. Food Chem., 2022, 70, 1494
DOI: 10.1021/acs.jafc.1c06417

P2Y12 antagonists: Approved drugs, potential naturally isolated and synthesised compounds, and related in-silico studies

Belal O. Al-Najjar, Fadi G. Saqallah, Manal A. Abbas, Serena Z. Al-Hijazeen and Obada A. Sibai

European Journal of Medicinal Chemistry, 2022, 227, 113924
DOI: 10.1016/j.ejmech.2021.113924

Identification of HMOX-1-Targeting Natural Compounds in Camellia nitidissima Chi for NSCLC Therapy: Integrating Bioassay and In Silico Screening Approaches

Lingqiu Zhang, Fan Zhang, Haimei Liang, Xiangling Qin, Chunmei Liang, Manlu Zhong, Yuemi Mo, Jinling Xie, Xiaotao Hou, Jiagang Deng, Erwei Hao and Zhengcai Du

Pharmaceuticals, 2025, 18, 824
DOI: 10.3390/ph18060824

The hypocoagulant effect ofCrataegus aroniain rats entails vitamin K‐dependent and vitamin K‐independent effects

Abdullah S. Shatoor, Ali Shati, Sulaiman M. Al Humayed, Abdulaziz K. Shatoor, Naif M. Alhawiti and Sultan A. Alqahtani

J Food Biochem, 2020, 44
DOI: 10.1111/jfbc.13094

Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!

Emine Yurt and Kadriye Toprak

Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 2024, 14, 450
DOI: 10.31020/mutftd.1486249

Rapid analysis and identification of flavonoid and organic acid metabolites in Hawthorn using an on-line flow injection assisted electrochemical microreactor combined with quadrupole time-of-flight tandem mass spectrometry

Juan Yang, Xin Dong, Xiao-Ting Zhen, Yan Chen, Hui Zheng, Li-Hong Ye, Fang-Ming Liu and Jun Cao

Journal of Food Composition and Analysis, 2021, 96, 103700
DOI: 10.1016/j.jfca.2020.103700

Research progress on the structural characterization, biological activity and product application of polysaccharides from Crataegus pinnatifida

Yongshuai Jing, Meng Yan, Dongbo Liu, Cheng Tao, Beibei Hu, Shiguo Sun, Yuguang Zheng and Lanfang Wu

International Journal of Biological Macromolecules, 2023, 244, 125408
DOI: 10.1016/j.ijbiomac.2023.125408

Potent antiplatelet aggregation, anticoagulant and antioxidant activity of aerial Canna x generalis L.H Bailey & E.Z Bailey and its phytoconstituents

Hong Luyen Le, Thi Minh Hang Nguyen, Thi Thom Vu, Thi Tu Oanh Nguyen, Huong Duong Thi Ly, Nguyen Thanh Le, Van Hung Nguyen and Thi Van Anh Nguyen

South African Journal of Botany, 2022, 147, 882
DOI: 10.1016/j.sajb.2022.03.035

Bioactive food components and their inhibitory actions in multiple platelet pathways

Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak and Asim K. Duttaroy

Journal of Food Biochemistry, 2022, 46
DOI: 10.1111/jfbc.14476

Microemulsion of Medicago marina Essential Oil: In Vitro Evaluation of Antimicrobial, Antibiofilm, Anticoagulant Effects, and In Silico Studies Involving Molecular Docking and ADME Prediction

Marwa Melliti, Emira Noumi, Mabrouk Horchani, Maha Mastouri, Mejdi Snoussi, Hichem Ben Jannet, Muhammad Zafar, Mozaniel Santana de Oliveira and Hayet Edziri

J. Comput. Biophys. Chem., 2025, 24, 421
DOI: 10.1142/S2737416524500649

Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking

Jie Ding, Jun Wu, Haoran Wei, Sui Li, Man Huang, Yan Wang and Qin Fang

Front. Cardiovasc. Med., 2022, 9
DOI: 10.3389/fcvm.2022.804801