Heat shock cognate 70 protein is a novel target of nobiletin and its colonic metabolites in inhibiting colon carcinogenesis

Zili Gao, Jinkai Zheng, Xian Wu, Sergey Savinov, Chengying Zhao and Hang Xiao

Food Funct., 2024, 15, 10447
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Polyphenols-rich extract from Pleurotus eryngii with growth inhibitory of HCT116 colon cancer cells and anti-inflammatory function in RAW264.7 cells

Qiuhui Hu, Biao Yuan, Hang Xiao, Liyan Zhao, Xian Wu, Kanyasiri Rakariyatham, Lei Zhong, Yanhui Han, Benard Muinde Kimatu and Wenjian Yang

Food Funct., 2018, 9, 1601
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Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis

Yue Sun, Yanhui Han, Mingyue Song, Noppawat Charoensinphon, Jinkai Zheng, Peiju Qiu, Xian Wu and Hang Xiao

Food Funct., 2019, 10, 7444
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Dietary resveratrol attenuated colitis and modulated gut microbiota in dextran sulfate sodium-treated mice

Fang Li, Yanhui Han, Xiaokun Cai, Min Gu, Jin Sun, Ce Qi, Tim Goulette, Mingyue Song, Zhengze Li and Hang Xiao

Food Funct., 2020, 11, 1063
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Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin

Shanshan Guo, Xian Wu, Jinkai Zheng, Noppawat Charoensinphon, Ping Dong, Peiju Qiu, Mingyue Song, Zhonghai Tang and Hang Xiao

Food Funct., 2018, 9, 3104
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The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites

Mingyue Song, Yaqi Lan, Xian Wu, Yanhui Han, Minqi Wang, Jinkai Zheng, Zhengze Li, Fang Li, Jiazhi Zhou, Jie Xiao, Yong Cao and Hang Xiao

Food Funct., 2020, 11, 4940
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A metabolite of nobiletin, 4′-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis

Xian Wu, Mingyue Song, Peiju Qiu, Fang Li, Minqi Wang, Jinkai Zheng, Qi Wang, Fei Xu and Hang Xiao

Food Funct., 2018, 9, 87
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In-vivo biotransformation of citrus functional components and their effects on health

Abhisek Karn, Chengying Zhao, Feilong Yang, Jiefen Cui, Zili Gao, Minqi Wang, Fengzhong Wang, Hang Xiao and Jinkai Zheng

Critical Reviews in Food Science and Nutrition, 2021, 61, 756
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Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

Yan Ding, Ruilin Hou, Jianqiang Yu, Chengguo Xing, Chunlin Zhuang and Zhuo Qu

Nutrients, 2023, 15, 491
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Mechanisms of flavonoid-mediated amelioration of MASLD: flavonoids, their metabolites or impact on gut microbes?

Ruxuan Chen, Xionghui Wu, Ning Yin, Enjun Xie, Shumin Sun, Jie Shen, Yunmei Chen, Fenghua Zhou, Tao Li, Qili Li, Donglin Su, Fuhua Fu, Gaoyang Li, Xiaopeng Li and Yang Shan

Critical Reviews in Food Science and Nutrition, 2026, 66, 2287
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Biosynthesis of citrus flavonoids and their health effects

Chengying Zhao, Feng Wang, Yunhe Lian, Hang Xiao and Jinkai Zheng

Critical Reviews in Food Science and Nutrition, 2020, 60, 566
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Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells

Nipin Sp, Dong Young Kang, Jin-Moo Lee and Kyoung-Jin Jang

IJMS, 2021, 22, 9843
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Mesoporous silica-based nanocarriers with dual response to pH and ROS for enhanced anti-inflammation therapy of 5-demethylnobiletin against psoriasis-like lesions

Yimin Wang, Yanan Zhang, Zhihui Yang, Lei Zhang, Xiangping Chen, Guliang Yang, Jianfeng Zhan, Shiming Li, Feng He and Guanwei Fan

International Journal of Pharmaceutics, 2023, 645, 123373
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Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis

Shuo Yuan, Peng Gao, Shourong Wu, Xiaomin Liang, Yuling Xiao, Pengfei Tu and Yong Jiang

Journal of Pharmaceutical and Biomedical Analysis, 2024, 238, 115842
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5-Demethylnobiletin Inhibits Cell Proliferation, Downregulates ID1 Expression, Modulates the NF-κB/TNF-α Pathway and Exerts Antileukemic Effects in AML Cells

Pei-Yi Chen, Chih-Yang Wang, En-Ci Tsao, Yu-Ting Chen, Ming-Jiuan Wu, Chi-Tang Ho and Jui-Hung Yen

IJMS, 2022, 23, 7392
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Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice

A. A. Alahmari, B. Sreekumar, V. Patel, M. Ashat, M. Alexandre, A. K. Uduman, E. O. Akinbiyi, A. Ceplenski, C. A. Shugrue, T. R. Kolodecik, N. Tashkandi, S. W. Messenger, G. E. Groblewski, F. S. Gorelick, E. C. Thrower and Francisco X. Real

PLoS ONE, 2018, 13, e0197362
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5-Demethylnobiletin Ameliorates Isoproterenol-Induced Cardiac Fibrosis and Apoptosis by Repressing the Sirt1/FOXO3a/NF-κB and Wnt/β-Catenin Pathways

Haiyan Du, Weizhong Huangfu, Zhonghua Liu, Gaopeng Jia, Feng Zhao and Wenjun Cheng

Biological & Pharmaceutical Bulletin, 2024, 47, 1774
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Identification of Xanthomicrol as a Major Metabolite of 5-Demethyltangeretin in Mouse Gastrointestinal Tract and Its Inhibitory Effects on Colon Cancer Cells

Xian Wu, Zhengze Li, Yue Sun, Fang Li, Zili Gao, Jinkai Zheng and Hang Xiao

Front. Nutr., 2020, 7
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Cloning of a CHS gene of Poncirus trifoliata and its expression in response to soil water deficit and arbuscular mycorrhizal fungi

Zhen Liu, Shen Cheng, Xiao-Qing Liu, Kamil Kuča, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Khalid F. Almutairi, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu and Ying-Ning Zou

Front. Plant Sci., 2022, 13
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5-Demethylnobiletin more potently inhibits colon cancer cell growth than nobiletin in vitro and in vivo

Yi-Siou Chiou, Yu-Nu Zheng, Mei-Ling Tsai, Ching-Shu Lai, Chi-Tang Ho and Min-Hsiung Pan

Journal of Food Bioactives, 2018, 91
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Nobiletin and 5‑demethylnobiletin ameliorate hypopharyngeal squamous cell carcinoma by suppressing TGF‑β‑mediated epithelial‑mesenchymal transition

Gloria Gutiérrez‑Venegas and Marisol Rosas‑Martínez

Oncol Lett, 2025, 29
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3, 3-Dimethylquercetin Inhibits the Proliferation of Human Colon Cancer RKO Cells through Inducing G2/M Cell Cycle Arrest and Apoptosis

Jianguo Wu, Jun Yi, Yanbin Wu, Xuzheng Chen, Jianwei Zeng, Jinzhong Wu and Wei Peng

ACAMC, 2019, 19, 402
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Anticancer Activity of Novel Plant Extracts and Compounds from Adenosma bracteosum (Bonati) in Human Lung and Liver Cancer Cells

Ngoc Hong Nguyen, Qui Thanh Hoai Ta, Quang Thang Pham, Thi Ngoc Han Luong, Van Trung Phung, Thuc-Huy Duong and Van Giau Vo

Molecules, 2020, 25, 2912
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Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention

Joanna Xuan Hui Goh, Loh Teng-Hern Tan, Joo Kheng Goh, Kok Gan Chan, Priyia Pusparajah, Learn-Han Lee and Bey-Hing Goh

Cancers, 2019, 11, 867
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Inhibitory effects of 7,7′-bromo-curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation

Kanyasiri Rakariyatham, Zheyuan Du, Biao Yuan, Zili Gao, Mingyue Song, Che Pan, Yanhui Han, Xian Wu, Zhonghai Tang, Guodong Zhang and Hang Xiao

European Journal of Pharmacology, 2019, 858, 172479
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Potential role of nobiletin in Alzheimer’s disease

Huilin Fang, Lingling Zhang and Hui Zhao

Journal of Food Bioactives, 2023, 29
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Comparison of Nobiletin and 5‐Demethylnobiletin as Cancer Chemopreventive Agents

Marisol Rosas-Martínez, Gloria Gutiérrez-Venegas and Canhui Cao

European Journal of Cancer Care, 2024, 2024
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DNA damage resulting from human endocrine disrupting chemical exposure: Genotoxicity, detection and dietary phytochemical intervention

Xiaoqing Li, Ningzi Zang, Nan Zhang, Lijian Pang, Ling Lv, Xiansheng Meng, Xiaodong Lv and Jiapeng Leng

Chemosphere, 2023, 338, 139522
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5-Demethylnobiletin: Insights into its pharmacological activity, mechanisms, pharmacokinetics and toxicity

Haiyan Ding, Qiang You, Dan Li and Youping Liu

Phytomedicine, 2022, 104, 154285
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Diallyl Disulfide Blocks Cigarette Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumorigenesis via Activation of the Nrf2 Antioxidant System and Suppression of NF-κB Inflammatory Response

Jiahui Tian, Wenli Zhao, Yanran Wu, Ying Shi, Jianqiang Yu, Wannian Zhang, Chengguo Xing, Chunlin Zhuang and Zhuo Qu

J. Agric. Food Chem., 2023, 71, 17763
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