Aryldiazoquinoline based multifunctional small molecules for modulating Aβ42aggregation and cholinesterase activity related to Alzheimer's disease

Monika Rana, Abhishek Pareek, Shivani Bhardwaj, Geeta Arya, Surendra Nimesh, Hemant Arya, Tarun K. Bhatt, Srinivasarao Yaragorla and Anuj K. Sharma

RSC Adv., 2020, 10, 28827
DOI: 10.1039/D0RA05172A

Role of hydrophobic residues for the gaseous formation of helical motifs

Lin Liu, Xin Dong, Yichang Liu, Nicklas Österlund, Astrid Gräslund, Paolo Carloni and Jinyu Li

Chem. Commun., 2019, 55, 5147
DOI: 10.1039/C9CC01898K

Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(iii) complex

Yuancun Zhou, Jiacheng Zhu, Furong Gao, Ming Hu, Chengyuan Qian, Xin Wang and Xiaohui Wang

Dalton Trans., 2024, 53, 14966
DOI: 10.1039/D4DT02188F

Atomistic investigation of an Iowa Amyloid-β trimer in aqueous solution

Son Tung Ngo, Huong Thi Thu Phung, Khanh B. Vu and Van V. Vu

RSC Adv., 2018, 8, 41705
DOI: 10.1039/C8RA07615D

Near-infrared irradiation controlled thermo-switchable polymeric photosensitizer against β-amyloid fibrillation

Li Chen, Zhe Zhou, Yuexing Zhang, Jie Pan, Kai Wang and Hang-Xing Wang

J. Mater. Chem. B, 2022, 10, 4832
DOI: 10.1039/D2TB00372D

Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a “V-shaped” spatial conformation

Jian Yang, Fantian Zeng, Xiaofang Li, Chongzhao Ran, Yungen Xu and Yuyan Li

Chem. Commun., 2020, 56, 583
DOI: 10.1039/C9CC08894F

Delineating the tryptophan–galactosylamine conjugate mediated structural distortions in Aβ42 protofibrils

Arushi Dabas and Bhupesh Goyal

Phys. Chem. Chem. Phys., 2025, 27, 7336
DOI: 10.1039/D4CP03330B

Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity

Zhi Du, Eunju Nam, Yuxi Lin, Mannkyu Hong, Tamás Molnár, Ikufumi Kondo, Koichiro Ishimori, Mu-Hyun Baik, Young-Ho Lee and Mi Hee Lim

Chem. Sci., 2023, 14, 5340
DOI: 10.1039/D3SC00881A

Keggin-type polyoxometalates as Cu(ii) chelators in the context of Alzheimer's disease

Elena Atrián-Blasco, Lucie de Cremoux, Xudong Lin, Rufus Mitchell-Heggs, Laurent Sabater, Sébastien Blanchard and Christelle Hureau

Chem. Commun., 2022, 58, 2367
DOI: 10.1039/D1CC05792H

Detection, inhibition and disintegration of amyloid fibrils: the role of optical probes and macrocyclic receptors

Achikanath C. Bhasikuttan and Jyotirmayee Mohanty

Chem. Commun., 2017, 53, 2789
DOI: 10.1039/C6CC08727B

Inorganic ion-sensitive imaging probes for biomedical applications

Qiyue Wang, Pengzhan Wang, Canyu Huang, Sirui Cui, Shengfei Yang, Fangyuan Li and Daishun Ling

Chem. Commun., 2023, 59, 5807
DOI: 10.1039/D3CC00418J

Recent developments in the chemical biology of amyloid-β oligomer targeting

Yalin Wang, Jiefang Chen, Furong Gao, Ming Hu and Xiaohui Wang

Org. Biomol. Chem., 2023, 21, 4540
DOI: 10.1039/D3OB00509G

Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ42oligomers by controlling their interactions with cell membranes

Zhengxin Yu, Weijie Guo, Shrey Patel, Hong-Jun Cho, Liang Sun and Liviu M. Mirica

Chem. Sci., 2022, 13, 12818
DOI: 10.1039/D2SC02654F

Modulation of Aβ1–40 and Aβ4–40 co-assembly by zinc: getting closer to the biological reality

Lucie de Cremoux, Enrico Falcone, David Schmitt, Ewelina Stefaniak, Marta D. Wiśniewska, Nicolas Vitale, Wojciech Bal and Christelle Hureau

Inorg. Chem. Front., 2025, 12, 7827
DOI: 10.1039/D5QI00850F

Detection and disaggregation of amyloid fibrils by luminescent amphiphilic platinum(ii) complexes

Zhuoheng Li, Akalanka B. Ekanayake, Anna E. Bartman, Jonathan A. Doorn, Alexei V. Tivanski and F. Christopher Pigge

Dalton Trans., 2024, 53, 9001
DOI: 10.1039/D4DT00882K

Application of carbon-based nanomaterials in Alzheimer's disease

Mengyao Bai, Xu Shao, Chao Wang, Juanxia Wang, Xin Wang, Ping Guan and Xiaoling Hu

Mater. Horiz., 2025, 12, 673
DOI: 10.1039/D4MH01256A

Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots

Ravit Malishev, Elad Arad, Susanta Kumar Bhunia, Shira Shaham-Niv, Sofiya Kolusheva, Ehud Gazit and Raz Jelinek

Chem. Commun., 2018, 54, 7762
DOI: 10.1039/C8CC03235A

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai-Ci Chan, Pei-Ya Shan, Men-Hsin Wu, Pin-Han Lin, Chang-Shun Tsai, Chia-Chien Hsu, Ting-Hsiang Chiu, Ting-Wei Hsu, Yi-Cheun Yeh, Yun-Ju Lai, Wei-Min Liu and Ling-Hsien Tu

Chem. Commun., 2023, 59, 10660
DOI: 10.1039/D3CC03363E

Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

Seongmin Park, Mingeun Kim, Yuxi Lin, Mannkyu Hong, Geewoo Nam, Adam Mieczkowski, József Kardos, Young-Ho Lee and Mi Hee Lim

Chem. Sci., 2023, 14, 9293
DOI: 10.1039/D3SC00752A

Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening

Hyuck Jin Lee, Young Geun Lee, Juhye Kang, Seung Hyun Yang, Ju Hwan Kim, Amar B. T. Ghisaidoobe, Hyo Jin Kang, Sang-Rae Lee, Mi Hee Lim and Sang J. Chung

Chem. Sci., 2019, 10, 1000
DOI: 10.1039/C8SC04943B

Fabrication and emulsifying properties of non-covalent complexes between soy protein isolate fibrils and soy soluble polysaccharides

Hekai Zhao, Shengnan Wang, Guilan Zhao, Yangyang Li, Xiulin Liu, Lina Yang, Lijie Zhu and He Liu

Food Funct., 2022, 13, 386
DOI: 10.1039/D1FO01604K

Dynamic micellar oligomers of amyloid beta peptides play a crucial role in their aggregation mechanisms

Bertrand Morel, Maria Paz Carrasco, Samuel Jurado, Carmen Marco and Francisco Conejero-Lara

Phys. Chem. Chem. Phys., 2018, 20, 20597
DOI: 10.1039/C8CP02685H

Chemical control of peptide material phase transitions

Junjun Tan, Li Zhang, Ming-Chien Hsieh, Jay T. Goodwin, Martha A. Grover and David G. Lynn

Chem. Sci., 2021, 12, 3025
DOI: 10.1039/D0SC03666H

Atomic resolution map of the soluble amyloid beta assembly toxic surfaces

Rashik Ahmed, Michael Akcan, Adree Khondker, Maikel C. Rheinstädter, José C. Bozelli, Richard M. Epand, Vincent Huynh, Ryan G. Wylie, Stephen Boulton, Jinfeng Huang, Chris P. Verschoor and Giuseppe Melacini

Chem. Sci., 2019, 10, 6072
DOI: 10.1039/C9SC01331H

Force clamp approach for characterization of nano-assembly in amyloid beta 42 dimer

Sibaprasad Maity and Yuri L. Lyubchenko

Nanoscale, 2019, 11, 12259
DOI: 10.1039/C9NR01670H

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K. Rajasekhar and Thimmaiah Govindaraju

RSC Adv., 2018, 8, 23780
DOI: 10.1039/C8RA03620A

Phosphorylation of covalent organic framework nanospheres for inhibition of amyloid-β peptide fibrillation

Linli Yao, Zhe Zhou, Suxiao Wang, Qichao Zou, Hang-Xing Wang, Li-Xin Ma, Shengfu Wang and Xiuhua Zhang

Chem. Sci., 2022, 13, 5902
DOI: 10.1039/D2SC00253A

Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition

Jeasang Yoo, Jimin Lee, Byeongha Ahn, Jiyeon Han and Mi Hee Lim

Chem. Sci., 2025, 16, 2105
DOI: 10.1039/D4SC06762B

Intrinsic visible emission of amyloid-β oligomers: a potential tool for early alzheimer's diagnosis

Mercedes Novo, Sara Illodo, Jesús Seijas, Stella Hernández, Flor Rodríguez-Prieto and Wajih Al-Soufi

Phys. Chem. Chem. Phys., 2025, 27, 16733
DOI: 10.1039/D5CP01547B

Metal–BODIPY complexes: versatile photosensitizers for oxidizing amyloid-β peptides and modulating their aggregation profiles

Mingeun Kim, Gajendra Gupta, Junseong Lee, Chanju Na, Jimin Kwak, Yuxi Lin, Young-Ho Lee, Mi Hee Lim and Chang Yeon Lee

Inorg. Chem. Front., 2024, 11, 1966
DOI: 10.1039/D3QI02445H

Human serum albumin-mediated recognition of soluble amyloid-β peptides using a time-resolved luminescent probe in plasma

Chengyi Yuan, Weiping Duan, Jian Luo, Yuwang Han and Xiaohui Wang

Chem. Commun., 2020, 56, 5945
DOI: 10.1039/D0CC01384F

Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo

Kazuma Murakami, Yoshiki Sakaguchi, Kota Taniwa, Naotaka Izuo, Mizuho Hanaki, Taiji Kawase, Kenji Hirose, Takahiko Shimizu and Kazuhiro Irie

RSC Chem. Biol., 2022, 3, 1380
DOI: 10.1039/D2CB00194B

Elastic moduli of biological fibers in a coarse-grained model: crystalline cellulose and β-amyloids

Adolfo B. Poma, Mateusz Chwastyk and Marek Cieplak

Phys. Chem. Chem. Phys., 2017, 19, 28195
DOI: 10.1039/C7CP05269C

Covalent organic frameworks as superior adsorbents for the removal of toxic substances

Yubo Li, Jinxia Wei, Jian Wang, Yuanyuan Wang, Peishuang Yu, Yao Chen and Zhenjie Zhang

Chem. Soc. Rev., 2025, 54, 2693
DOI: 10.1039/D4CS00591K

Aptamer conjugated polydopamine-coated gold nanoparticles as a dual-action nanoplatform targeting β-amyloid peptide for Alzheimer's disease therapy

Juan Qin, Yanxue Guan, Zongjia Li, Xinyue Guo, Miaomiao Zhang, Dapeng Wang and Jilin Tang

J. Mater. Chem. B, 2022, 10, 8525
DOI: 10.1039/D2TB01499H

Mechanistic insight into functionally different human islet polypeptide (hIAPP) amyloid: the intrinsic role of the C-terminal structural motifs

Dibakar Sarkar, Narayan Chandra Maity, Gourav Shome, Kyriakos Gabriel Varnava, Vijayalekshmi Sarojini, Subramanian Vivekanandan, Nirakar Sahoo, Sourav Kumar, Atin Kumar Mandal, Ranjit Biswas and Anirban Bhunia

Phys. Chem. Chem. Phys., 2022, 24, 22250
DOI: 10.1039/D2CP01650H

A new therapeutic perspective on metal-based drugs

Rodrigo Castro-Ramírez and Norah Barba-Behrens

Dalton Trans., 2025, 54, 15964
DOI: 10.1039/D5DT01567G

High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease

Bikash R. Sahoo, Sarah J. Cox and Ayyalusamy Ramamoorthy

Chem. Commun., 2020, 56, 4627
DOI: 10.1039/D0CC01551B

Antioxidant and copper-chelating power of new molecules suggested as multiple target agents against Alzheimer's disease. A theoretical comparative study

Maciej Spiegel, Tiziana Marino, Mario Prejanò and Nino Russo

Phys. Chem. Chem. Phys., 2022, 24, 16353
DOI: 10.1039/D2CP01918C

Liquid–liquid phase separation induced by crowding condition affects amyloid-β aggregation mechanism

Ryuki Kobayashi and Hideki Nabika

Soft Matter, 2024, 20, 5331
DOI: 10.1039/D4SM00470A

Metal-chelating benzothiazole multifunctional compounds for the modulation and 64Cu PET imaging of Aβ aggregation

Yiran Huang, Hong-Jun Cho, Nilantha Bandara, Liang Sun, Diana Tran, Buck E. Rogers and Liviu M. Mirica

Chem. Sci., 2020, 11, 7789
DOI: 10.1039/D0SC02641G

Implantable hydrogels as pioneering materials for next-generation brain–computer interfaces

Wasid Ullah Khan, Zhenzhen Shen, Samuel M. Mugo, Hongda Wang and Qiang Zhang

Chem. Soc. Rev., 2025, 54, 2832
DOI: 10.1039/D4CS01074D

Understanding the mechanisms of green tea EGCG against amyloid β oligomer neurotoxicity through computational studies

Priscila Baltazar Gonçalves, Yraima Cordeiro and Ana Carolina Rennó Sodero

RSC Adv., 2024, 14, 22525
DOI: 10.1039/D4RA03343D

Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation

Juhye Kang, Jung Seung Nam, Hyuck Jin Lee, Geewoo Nam, Hyun-Woo Rhee, Tae-Hyuk Kwon and Mi Hee Lim

Chem. Sci., 2019, 10, 6855
DOI: 10.1039/C9SC00931K

Small molecule-mediated co-assembly of amyloid-β oligomers reduces neurotoxicity through promoting non-fibrillar aggregation

Hao Liu, Chengyuan Qian, Tao Yang, Yanqing Wang, Jian Luo, Changli Zhang, Xiaohui Wang, Xiaoyong Wang and Zijian Guo

Chem. Sci., 2020, 11, 7158
DOI: 10.1039/D0SC00392A

Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

Peter Verwilst, Hyeong Seok Kim, Soobin Kim, Chulhun Kang and Jong Seung Kim

Chem. Soc. Rev., 2018, 47, 2249
DOI: 10.1039/C7CS00706J

Single molecule sensing of amyloid-β aggregation by confined glass nanopores

Ru-Jia Yu, Si-Min Lu, Su-Wen Xu, Yuan-Jie Li, Qun Xu, Yi-Lun Ying and Yi-Tao Long

Chem. Sci., 2019, 10, 10728
DOI: 10.1039/C9SC03260F

Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles

Hao Geng, Hongbo Yuan, Liang Qiu, Dong Gao, Yongqiang Cheng and Chengfen Xing

J. Mater. Chem. B, 2020, 8, 10126
DOI: 10.1039/D0TB01863E

Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)–amyloid-β

Yelim Yi, Jiyeon Han, Min Hee Park, Nahye Park, Eunju Nam, Hee Kyung Jin, Jae-sung Bae and Mi Hee Lim

Chem. Commun., 2019, 55, 5847
DOI: 10.1039/C9CC01005J

Multi-target macrocycles: pyrogallol derivatives to control multiple pathological factors associated with Alzheimer's disease

Jimin Kwak, Yelim Yi, Seongmin Park and Mi Hee Lim

Chem. Sci., 2025, 16, 889
DOI: 10.1039/D4SC06417H

Chiral supramolecular coordination cages as high-performance inhibitors against amyloid-β aggregation

Ling-Yu Bao, Si-Jia Hao, Sai-Fei Xi, Xiaodong Yan, Hai-Xia Zhang, Rui Shen and Zhi-Guo Gu

Chem. Commun., 2018, 54, 8725
DOI: 10.1039/C8CC04913K

Calprotectin influences the aggregation of metal-free and metal-bound amyloid-β by direct interaction

Hyuck Jin Lee, Masha G. Savelieff, Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Shin Jung C. Lee, Elizabeth M. Nolan and Mi Hee Lim

Metallomics, 2018, 10, 1116
DOI: 10.1039/C8MT00091C

Multiple reactivities of flavonoids towards pathological elements in Alzheimer's disease: structure–activity relationship

Geewoo Nam, Mannkyu Hong, Juri Lee, Hyuck Jin Lee, Yonghwan Ji, Juhye Kang, Mu-Hyun Baik and Mi Hee Lim

Chem. Sci., 2020, 11, 10243
DOI: 10.1039/D0SC02046J

Necessity of regulatory guidelines for the development of amyloid based biomaterials

Vijay Kumar, Nabodita Sinha and Ashwani Kumar Thakur

Biomater. Sci., 2021, 9, 4410
DOI: 10.1039/D1BM00059D

Current understanding of metal-dependent amyloid-β aggregation and toxicity

Yelim Yi and Mi Hee Lim

RSC Chem. Biol., 2023, 4, 121
DOI: 10.1039/D2CB00208F

Modulating protein amyloid aggregation with nanomaterials

Bo Wang, Emily H. Pilkington, Yunxiang Sun, Thomas P. Davis, Pu Chun Ke and Feng Ding

Environ. Sci.: Nano, 2017, 4, 1772
DOI: 10.1039/C7EN00436B

Fusion of amyloid beta with ferritin yields an isolated oligomeric beta-sheet-rich aggregate inside the ferritin cage

Basudev Maity, Shiori Kameyama, Jiaxin Tian, Thuc Toan Pham, Satoshi Abe, Eri Chatani, Kazuyoshi Murata and Takafumi Ueno

Biomater. Sci., 2024, 12, 2408
DOI: 10.1039/D4BM00173G

Metal binding to the amyloid-β peptides in the presence of biomembranes: potential mechanisms of cell toxicity

Sebastian K. T. S. Wärmländer, Nicklas Österlund, Cecilia Wallin, Jinming Wu, Jinghui Luo, Ann Tiiman, Jüri Jarvet and Astrid Gräslund

J Biol Inorg Chem, 2019, 24, 1189
DOI: 10.1007/s00775-019-01723-9

The Therapeutic Potential of Glymphatic System Activity to Reduce the Pathogenic Accumulation of Cytotoxic Proteins in Alzheimer’s Disease

Kamila Kopeć, Dariusz Koziorowski and Stanisław Szlufik

IJMS, 2025, 26, 7552
DOI: 10.3390/ijms26157552

A Biocompatible Second Near-Infrared Nanozyme for Spatiotemporal and Non-Invasive Attenuation of Amyloid Deposition through Scalp and Skull

Mengmeng Ma, Nan Gao, Xuexia Li, Zhenqi Liu, Zifeng Pi, Xiubo Du, Jinsong Ren and Xiaogang Qu

ACS Nano, 2020, 14, 9894
DOI: 10.1021/acsnano.0c02733

Amyloid fibrils in Alzheimer's disease differently modulate sleep and cortical oscillations in mice depending on the type of amyloid

Tomomi Sanagi, Masaki Okumura, Yuxi Lin, Shingo Kanemura, Eunyoung Moon, Yunseok Heo, Keiko Takahara, Young-Ho Lee and Tomomi Tsunematsu

Biophysical Chemistry, 2026, 333, 107599
DOI: 10.1016/j.bpc.2026.107599

Organoplatinum‐Substituted Polyoxometalate Inhibits β‐amyloid Aggregation for Alzheimer's Therapy

Jing Zhao, Kexin Li, Kaiwei Wan, Tiedong Sun, Nannan Zheng, Fanjiao Zhu, Jichao Ma, Jia Jiao, Tianchan Li, Jinyuan Ni, Xinghua Shi, Hui Wang, Qiang Peng, Jing Ai, Wanhai Xu and Shaoqin Liu

Angewandte Chemie, 2019, 131, 18200
DOI: 10.1002/ange.201910521

Oxidation of TDMQ20, a Specific Copper Chelator as Potential Drug Against Alzheimer's Disease

Michel Nguyen, Youzhi Li, Anne Robert, Yan Liu and Bernard Meunier

ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202204877

The Beneficial Role of Natural Endocrine Disruptors: Phytoestrogens in Alzheimer’s Disease

Anita Domańska, Arkadiusz Orzechowski, Anna Litwiniuk, Małgorzata Kalisz, Wojciech Bik, Agnieszka Baranowska-Bik and Antonella Smeriglio

Oxidative Medicine and Cellular Longevity, 2021, 2021
DOI: 10.1155/2021/3961445

Conformational Essentials Responsible for Neurotoxicity of Aβ42 Aggregates Revealed by Antibodies against Oligomeric Aβ42

Chuli Song, Tianyu Zhang and Yingjiu Zhang

Molecules, 2022, 27, 6751
DOI: 10.3390/molecules27196751

Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model

Wan-yi Li, Jun-yan Gao, Su-Yang Lin, Shao-tao Pan, Biao Xiao, Yu-tao Ma, Kai Xie, Wei Shen, Zhi-tao Liu, Guang-yu Li, Jie-jie Guo, Qin-wen Wang and Li-ping Li

Mol Neurobiol, 2022, 59, 3254
DOI: 10.1007/s12035-022-02784-9

A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for In Vivo Imaging of Amyloid-β Species

Daqing Fang, Donghui Pan, Xidan Wen, Junya Zhang, Min Yang, Deju Ye and Hong Liu

ACS Chem. Neurosci., 2024, 15, 472
DOI: 10.1021/acschemneuro.3c00377

Stepwise Coordination-Driven Metal–Phenolic Nanoparticle as a Neuroprotection Enhancer for Alzheimer’s Disease Therapy

Zhihui Yin, Zhixin Zhang, Demin Gao, Gan Luo, Tao Ma, Ying Wang, Lehui Lu and Xiaoyan Gao

ACS Appl. Mater. Interfaces, 2023, 15, 524
DOI: 10.1021/acsami.2c18060

Amphiphilic Tetraphenylethylene Derivative with Hydrophobic–Hydrophilic Complementarity to Amyloid Oligomers for in Situ Imaging and Modulation of Membrane-Disruptive Neurotoxicity

Jian Chen, Xiongwei Tang, Yichen Hu, Huixia Feng, Guanxin Zhang, Deqing Zhang, Yanyan Huang and Rui Zhao

Anal. Chem., 2026, 98, 2464
DOI: 10.1021/acs.analchem.5c07117

The anti‐prion RNA aptamer R12 disrupts the Alzheimer's disease‐related complex between prion and amyloid β

Mamiko Iida, Tsukasa Mashima, Yudai Yamaoki, Masatomo So, Takashi Nagata and Masato Katahira

The FEBS Journal, 2019, 286, 2355
DOI: 10.1111/febs.14819

Multi-target nanocomposites for Alzheimer’s treatment via microenvironment modulation and β-amyloid plaque clearance

Tongtong Hou, Dan Nie, Minling Ding, Chaoli Wang, Kun Mei, Xuanzhao Lu, Xin Wang, Selene Tang, Hong Wu, Ping Guan, Wenlei Zhu and Xiaoling Hu

Journal of Materials Science & Technology, 2026, 248, 281
DOI: 10.1016/j.jmst.2025.04.081

Extracellular vesicles from amyloid-β exposed cell cultures induce severe dysfunction in cortical neurons

Chiara Beretta, Elisabeth Nikitidou, Linn Streubel-Gallasch, Martin Ingelsson, Dag Sehlin and Anna Erlandsson

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-72355-2

Current Strategies for Modulating Aβ Aggregation with Multifunctional Agents

Zhi Du, Meng Li, Jinsong Ren and Xiaogang Qu

Acc. Chem. Res., 2021, 54, 2172
DOI: 10.1021/acs.accounts.1c00055

Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases

Sijian Wang, Biyao Wang, Dehao Shang, Kaige Zhang, Xu Yan and Xinwen Zhang

Front. Physiol., 2022, 13
DOI: 10.3389/fphys.2022.814285

Curcumin ligand based iridium(III) complexes as inhibition and visualization agent of beta-amyloid fibrillation

Yunwei Zhao, Junde Li, Zhen Wu, Hui Zhang, Yanfang Zhao, Ruimei Yang and Lihua Lu

Microchemical Journal, 2021, 160, 105721
DOI: 10.1016/j.microc.2020.105721

Inhibitory Effects of Sulfated Polysaccharides from the Sea CucumberCucumaria Frondosaagainst Aβ40 Aggregation and Cytotoxicity

Gao Li, Yu Zhou, Wu-Yue Yang, Chen Zhang, Liu Hong and Lee Jia

ACS Chem. Neurosci., 2021, 12, 1854
DOI: 10.1021/acschemneuro.1c00223

Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease

Joanna Żukowska, Stephen J. Moss, Vasanta Subramanian and K. Ravi Acharya

The FEBS Journal, 2024, 291, 2999
DOI: 10.1111/febs.16939

Formation and physicochemical properties of amyloid fibrils from soy protein

Yajuan Wang, Yanting Shen, Guangyan Qi, Ya Li, Xiuzhi Susan Sun, Dan Qiu and Yonghui Li

International Journal of Biological Macromolecules, 2020, 149, 609
DOI: 10.1016/j.ijbiomac.2020.01.258

Interdisciplinary Approaches to Deal with Alzheimer’s Disease—From Bench to Bedside: What Feasible Options Do Already Exist Today?

Irene Ablinger, Katharina Dressel, Thea Rott, Anna Andrea Lauer, Michael Tiemann, João Pedro Batista, Tim Taddey, Heike Sabine Grimm and Marcus Otto Walter Grimm

Biomedicines, 2022, 10, 2922
DOI: 10.3390/biomedicines10112922

Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer’s disease related oligomers

Tobias Lieblein, Rene Zangl, Janosch Martin, Jan Hoffmann, Marie J Hutchison, Tina Stark, Elke Stirnal, Thomas Schrader, Harald Schwalbe and Nina Morgner

eLife, 2020, 9
DOI: 10.7554/eLife.59306

A Unified View of Assessing the Pro‐oxidant versus Antioxidant Nature of Amyloid Beta Conformers

Suchitra Mitra, Pallavi Prasad and Saumen Chakraborty

ChemBioChem, 2018, 19, 2360
DOI: 10.1002/cbic.201800446

Interactions between Lipid Vesicle Membranes and Single Amino Acid Fibrils: Probable Origin of Specific Neurological Disorders

Sourav Nandi and Nilmoni Sarkar

Langmuir, 2024, 40, 1971
DOI: 10.1021/acs.langmuir.3c02429

Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer’s Disease

Oluyomi Stephen Adeyemi, Oluwakemi Josephine Awakan, Lawrence Boluwatife Afolabi, Damilare Emmanuel Rotimi, Elizabeth Oluwayemi, Chiagoziem A. Otuechere, Omodele Ibraheem, Tobiloba Chritiana Elebiyo, Omokolade Alejolowo, Afolake T. Arowolo and Erica Buoso

Oxidative Medicine and Cellular Longevity, 2021, 2021
DOI: 10.1155/2021/5522981

Serum albumin-embedding copper nanoclusters inhibit Alzheimer’s β-amyloid fibrillogenesis and neuroinflammation

Luqi Liu, Wei Liu, Yan Sun and Xiaoyan Dong

Journal of Colloid and Interface Science, 2024, 672, 53
DOI: 10.1016/j.jcis.2024.05.193

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils

Ravit Malishev, Shani Ben-Zichri, Ofek Oren, Nitzan Shauloff, Tal Peretz, Ran Taube, Niv Papo and Raz Jelinek

Cell. Mol. Life Sci., 2021, 78, 2145
DOI: 10.1007/s00018-020-03623-7

Protein aggregation: From background to inhibition strategies

Parvez Alam, Khursheed Siddiqi, Sumit Kumar Chturvedi and Rizwan Hasan Khan

International Journal of Biological Macromolecules, 2017, 103, 208
DOI: 10.1016/j.ijbiomac.2017.05.048

Mass spectrometry analysis of the diversity of Aβ peptides: difficulties and future perspectives for AD biomarker discovery

Natalia V. Zakharova, Anna E. Bugrova, Alexey S. Kononikhin, Maria I. Indeykina, Igor A. Popov and Eugene N. Nikolaev

Expert Review of Proteomics, 2018, 15, 773
DOI: 10.1080/14789450.2018.1525296

Sodium-salt adduct fullerenes prevent self-association and amyloid β fibril formation: molecular dynamics approach

Miguel Angel Balderas Altamirano, Gustavo Basurto-Islas, Melchor Martínez-Herrera, Juan Luis Pichardo Molina and Susana Figueroa-Gerstenmaier

Soft Materials, 2020, 18, 335
DOI: 10.1080/1539445X.2020.1746336

Plasma Biomarkers: Potent Screeners of Alzheimer’s Disease

Muhammad Naveed, Shamsa Mubeen, Abeer Khan, Sehrish Ibrahim and Bisma Meer

Am J Alzheimers Dis Other Demen, 2019, 34, 290
DOI: 10.1177/1533317519848239

Peptide Self‐Assembly into Amyloid Fibrils at Hard and Soft Interfaces—From Corona Formation to Membrane Activity

Torsten John, Lisandra L. Martin and Bernd Abel

Macromolecular Bioscience, 2023, 23
DOI: 10.1002/mabi.202200576

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

Sara Linse, Tom Scheidt, Katja Bernfur, Michele Vendruscolo, Christopher M. Dobson, Samuel I. A. Cohen, Eimantas Sileikis, Martin Lundqvist, Fang Qian, Tiernan O’Malley, Thierry Bussiere, Paul H. Weinreb, Catherine K. Xu, Georg Meisl, Sean R. A. Devenish, Tuomas P. J. Knowles and Oskar Hansson

Nat Struct Mol Biol, 2020, 27, 1125
DOI: 10.1038/s41594-020-0505-6

Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease

Chun‐ni Zhou, Feng‐lei Chao, Yi Zhang, Lin Jiang, Lei Zhang, Jin‐hua Fan, Yong‐xin Wu, Xiao‐yun Dou and Yong Tang

J of Comparative Neurology, 2019, 527, 1378
DOI: 10.1002/cne.24616

Insights into Mechanism of Aβ42 Fibril Growth on Surface of Graphene Oxides: Oxidative Degree Matters

Huan He, Juan Xu, Chen‐Qiao Li, Tian Gao, Peng Jiang, Feng‐Lei Jiang and Yi Liu

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100436

Nanopore‐Based, Rapid Characterization of Individual Amyloid Particles in Solution: Concepts, Challenges, and Prospects

Jared Houghtaling, Jonathan List and Michael Mayer

Small, 2018, 14
DOI: 10.1002/smll.201802412

A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact Cells

Segev Naveh Tassa, Shani Ben Zichri, Shiran Lacham-Hartman, Ofek Oren, Zeev Slobodnik, Ekaterina Eremenko, Debra Toiber, Raz Jelinek and Niv Papo

ACS Chem. Neurosci., 2021, 12, 1563
DOI: 10.1021/acschemneuro.1c00045

Perphenazine–Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid

Sarah R. Ball, Julius S. P. Adamson, Michael A. Sullivan, Manuela R. Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H. Kwan, André D. J. McKenzie, Eryn L. Werry, Tuomas P. J. Knowles, Michael Kassiou, Georg Meisl, Matthew H. Todd, Peter J. Rutledge and Margaret Sunde

ACS Chem. Neurosci., 2023, 14, 87
DOI: 10.1021/acschemneuro.2c00498

Real-Time Monitoring of Self-Aggregation of β-Amyloid by a Fluorescent Probe Based on Ruthenium Complex

Hui-juan Yu, Wei Zhao, Mengting Xie, Xiaoqing Li, Ming Sun, Jun He, Lu Wang and Lin Yu

Anal. Chem., 2020, 92, 2953
DOI: 10.1021/acs.analchem.9b03566

Protein Oligomer Engineering: A New Frontier for Studying Protein Structure, Function, and Toxicity

Chang Liu and Jinghui Luo

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202216480

Pathways of Amyloid-β Aggregation Depend on Oligomer Shape

Bogdan Barz, Qinghua Liao and Birgit Strodel

J. Am. Chem. Soc., 2018, 140, 319
DOI: 10.1021/jacs.7b10343

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

Magnus Kjaergaard, Alexander J. Dear, Franziska Kundel, Seema Qamar, Georg Meisl, Tuomas P. J. Knowles and David Klenerman

ACS Chem. Neurosci., 2018, 9, 3060
DOI: 10.1021/acschemneuro.8b00250

Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β

Jiyeon Han, Jiwon Yoon, Jeongcheol Shin, Eunju Nam, Tongrui Qian, Yulong Li, Kiyoung Park, Seung-Hee Lee and Mi Hee Lim

Nat. Chem., 2022, 14, 1021
DOI: 10.1038/s41557-022-00984-3

The role of quinoline in the development of near-infrared fluorescent probes for diagnosis of Alzheimer's disease

Lúcia Melo, Artur M.S. Silva and Hélio M.T. Albuquerque

European Journal of Medicinal Chemistry, 2025, 296, 117874
DOI: 10.1016/j.ejmech.2025.117874

Lead induced intracellular copper redox imbalance with aggravated cellular dysfunction

Jingyi Hu and Wen-Xiong Wang

Environmental Pollution, 2025, 382, 126710
DOI: 10.1016/j.envpol.2025.126710

Dual-Mode Chalcone-Based Fluorescent Probe for Distinguishing Amyloid-β Oligomers and Fibrils via Microenvironment Sensitivity

Zhe Zhou, Zi-Xin Chen, Yi-Ting Zeng, Chaiqin Shi, Wen-Lin Tang, Li-Wen Zhang, You Cheng, Yuexing Zhang, Pan Wu and Hang-Xing Wang

Anal. Chem., 2025, 97, 24643
DOI: 10.1021/acs.analchem.5c04779

Cobalt complexes as modulators against amyloid-β aggregation

Jeasang Yoo, Jong-Min Suh, Gunhee Kim, Hélène Bernard, Raphaël Tripier, Dongwook Kim, Mingeun Kim and Mi Hee Lim

Journal of Inorganic Biochemistry, 2025, 271, 112972
DOI: 10.1016/j.jinorgbio.2025.112972

N,N-Dimethylaminonaphthyl-modified dicyanoisophorone near-infrared probe for dual-functional imaging of β-amyloid aggregates and lipid droplets

Huiyuan Gong, Ru Fang, Song Luo, Wen Luo and Yongmei Zhao

Journal of Molecular Structure, 2025, 1344, 142932
DOI: 10.1016/j.molstruc.2025.142932

Fluorescence-Based Monitoring of Early-Stage Aggregation of Amyloid-β, Amylin Peptide, Tau, and α-Synuclein Proteins

Yuanjie Li, Saurabh Awasthi, Louise Bryan, Rachel S. Ehrlich, Nicolo Tonali, Sandor Balog, Jerry Yang, Norbert Sewald and Michael Mayer

ACS Chem. Neurosci., 2024, 15, 3113
DOI: 10.1021/acschemneuro.4c00097

GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease

Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang and Bo Su

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2024, 1870, 167093
DOI: 10.1016/j.bbadis.2024.167093

Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

Ofek Oren, Ran Taube and Niv Papo

Cell. Mol. Life Sci., 2021, 78, 7185
DOI: 10.1007/s00018-021-03954-z

Importance of Hydrogen Bonding: Structure–Activity Relationships of Ruthenium(III) Complexes with Pyridine-Based Ligands for Alzheimer’s Disease Therapy

Brendan J. Wall, Mark F. Will, Gideon K. Yawson, Paige J. Bothwell, David C. Platt, C. Fiore Apuzzo, Marjorie A. Jones, Gregory M. Ferrence and Michael I. Webb

J. Med. Chem., 2021, 64, 10124
DOI: 10.1021/acs.jmedchem.1c00360

Red emissive fluorescent carbon dots based on ternary carbon source for imaging α-synuclein fibrils

Jintao Zhang, Wan-Chun Luo, Yu Zhang, Xi Li, Ming Jiang, Kun Huang, Xu Yu and Li Xu

Journal of Colloid and Interface Science, 2024, 670, 576
DOI: 10.1016/j.jcis.2024.05.129

Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides

Elina Berntsson, Faraz Vosough, Teodor Svantesson, Jonathan Pansieri, Igor A. Iashchishyn, Lucija Ostojić, Xiaolin Dong, Suman Paul, Jüri Jarvet, Per M. Roos, Andreas Barth, Ludmilla A. Morozova-Roche, Astrid Gräslund and Sebastian K. T. S. Wärmländer

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-29901-5

PPARα-Mediated Fatty Acid Catabolism in Astrocytes Was Involved in Improvement of Cognitive Dysfunction by Phlorizin in APP/PS1 Mice

Yan Fu, Xuya Zhang, Lingling Li, Hong Jiang, Qiaozhi Ren, Tianxing Yi, Yali Zhang and Yi Lu

Antioxidants, 2025, 14, 1321
DOI: 10.3390/antiox14111321

Total Synthesis and Amyloid β Aggregation Inhibitory Activity of (−)-L-755,807

Kosaku Tanaka III, Kenichi Kobayashi and Hiroshi Kogen

J. Synth. Org. Chem. Jpn., 2019, 77, 673
DOI: 10.5059/yukigoseikyokaishi.77.673

Curved Nanointerface Controls the Chiral Effect on Peptide Fibrillation

Luping Li, Qianyan Duan, Yanan Deng, Zhongju Ye and Lehui Xiao

ACS Appl. Mater. Interfaces, 2024, 16, 53532
DOI: 10.1021/acsami.4c11858

Promoted Aggregation of Aβ on Lipid Bilayers in an Open Flowing System

Akane Iida, Mitsuhiro Abe, Miona Nochi, Chiaki Soga, Kei Unoura and Hideki Nabika

J. Phys. Chem. Lett., 2021, 12, 4453
DOI: 10.1021/acs.jpclett.1c00524

Quercetin Encapsulated Polymer Nanoparticle for Inhibiting Intracellular Polyglutamine Aggregation

Koushik Debnath, Nihar R. Jana and Nikhil R. Jana

ACS Appl. Bio Mater., 2019, 2, 5298
DOI: 10.1021/acsabm.9b00518

Amyloid-β-targeting immunotherapies for Alzheimer's disease

Yi Jin, Qiaofei Du, Mingjie Song, Ruixin Kang, Jianping Zhou, Huaqing Zhang and Yang Ding

Journal of Controlled Release, 2024, 375, 346
DOI: 10.1016/j.jconrel.2024.09.012

Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

Charlène Esmieu, Djamila Guettas, Amandine Conte-Daban, Laurent Sabater, Peter Faller and Christelle Hureau

Inorg. Chem., 2019, 58, 13509
DOI: 10.1021/acs.inorgchem.9b00995

Engineering Versatile Nanoparticles for Near‐Infrared Light‐Tunable Drug Release and Photothermal Degradation of Amyloid β

Yi Lai, Yingying Zhu, Zhiai Xu, Xianli Hu, Madiha Saeed, Haijun Yu, Xingxing Chen, Jun Liu and Wen Zhang

Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.201908473

A novel photoelectrochemical aptasensor for Aβ42 monomer detection based on in-situ grown covalent organic frameworks

Xuejun Li, Meng Yuan, Ting Han, Qingnan Han, Linli Yao and Xinjian Song

Microchemical Journal, 2025, 217, 114974
DOI: 10.1016/j.microc.2025.114974

β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization

Willy Smeralda, Marc Since, Julien Cardin, Sophie Corvaisier, Sophie Lecomte, Christophe Cullin and Aurélie Malzert-Fréon

International Journal of Biological Macromolecules, 2021, 181, 769
DOI: 10.1016/j.ijbiomac.2021.03.107

Native PEG–PLGA Attenuates β-Amyloid Aggregation and Toxicity under In Vitro Conditions

Mallesh Rathnam, Haley Hunter, Pallabi Sil Paul, Ralf Schirrmacher, Michael J. Serpe and Satyabrata Kar

ACS Chem. Neurosci., 2025, 16, 4446
DOI: 10.1021/acschemneuro.5c00379

Neuroprotective Evaluation of Murraya Carbazoles: In Vitro and Docking Insights into Their Anti-AChE and Anti-Aβ Activities

Himadri Sharma, Niti Sharma and Seong Soo A. An

Molecules, 2025, 30, 3138
DOI: 10.3390/molecules30153138

BODIPY Dyes as Probes and Sensors to Study Amyloid-β-Related Processes

Sergei V. Dzyuba

Biosensors, 2020, 10, 192
DOI: 10.3390/bios10120192

Metabolite assemblies: A surprising extension to the amyloid hypothesis

Nidhi Gour and Ehud Gazit

Current Opinion in Chemical Biology, 2021, 64, 154
DOI: 10.1016/j.cbpa.2021.07.005

An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity

Qijia Wei, Dangliang Liu, Wencheng Xia, Fengzhang Wang, Lu Huang, Jun Zhang, Xiaoya Wang, Zhongxin Xu, Changdong He, Wenzhe Li, Xiaomeng Shi, Chu Wang, Yuan Liu, Cong Liu and Suwei Dong

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-60978-w

Novel combination of Olesoxime/Resveratrol-encapsulated exosomes to improve cognitive function by targeting amyloid β-induced Alzheimer’s disease: investigation on in vitro and in vivo model

Zhuo Wang, Chao Gao, Lei Zhang and Rubo Sui

Inflammopharmacol, 2024, 32, 2613
DOI: 10.1007/s10787-024-01476-1

Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells

Kate Elizabeth Hawkins and Michael R Duchen

WJSC, 2019, 11, 236
DOI: 10.4252/wjsc.v11.i5.236

Cytotoxic Aβ Protofilaments Are Generated in the Process of Aβ Fibril Disaggregation

Toshisuke Kaku, Kaori Tsukakoshi and Kazunori Ikebukuro

IJMS, 2021, 22, 12780
DOI: 10.3390/ijms222312780

Protein Oligomer Engineering: A New Frontier for Studying Protein Structure, Function, and Toxicity

Chang Liu and Jinghui Luo

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202216480

Oligomeric Amyloid-β and Tau Alter Cell Adhesion Properties and Induce Inflammatory Responses in Cerebral Endothelial Cells Through the RhoA/ROCK Pathway

Faruk Hossen, Xue Geng, Grace Y. Sun, Xincheng Yao and James C. Lee

Mol Neurobiol, 2024, 61, 8759
DOI: 10.1007/s12035-024-04138-z

Antibody-Free Determinations of Low-Mass, Soluble Oligomers of Aβ42 and Aβ40 by Planar Bilayer Lipid Membrane-Based Electrochemical Biosensor

Yuemei Duan, Jia Chen, Yan Jin, Qiuyun Tu, Shuhui Wang and Juan Xiang

Anal. Chem., 2021, 93, 3611
DOI: 10.1021/acs.analchem.0c05281

Amyloid Mimicking Assemblies Formed by Glutamine, Glutamic Acid, and Aspartic Acid

Ankita Jaiswal, Monisha Patel, Anam Naseer, Simran Kumari, Neeraja Revi, Aravind Rengan, Alok Jain, Aamir Nazir, Nidhi Gour and Sandeep Verma

ACS Chem. Neurosci., 2024, 15, 2253
DOI: 10.1021/acschemneuro.4c00082

The Conspicuous Link between Ear, Brain and Heart–Could Neurotrophin-Treatment of Age-Related Hearing Loss Help Prevent Alzheimer’s Disease and Associated Amyloid Cardiomyopathy?

Sergey Shityakov, Kentaro Hayashi, Stefan Störk, Verena Scheper, Thomas Lenarz and Carola Y. Förster

Biomolecules, 2021, 11, 900
DOI: 10.3390/biom11060900

Interactions of intrinsically disordered proteins with the unconventional chaperone human serum albumin: From mechanisms of amyloid inhibition to therapeutic opportunities

Karla Martinez Pomier, Rashik Ahmed and Giuseppe Melacini

Biophysical Chemistry, 2022, 282, 106743
DOI: 10.1016/j.bpc.2021.106743

Primary Cilia and Cardiovascular Risk Factors in Alzheimer’s Disease

Clare L. Sunderman, Kathleen V. Forero, Qasim Alorjani, Raghad Buqaileh, Gillian M. Gallagher, Sestina M. Ventresca, William S. Messer and Wissam A. AbouAlaiwi

Brain Sciences, 2025, 15, 1004
DOI: 10.3390/brainsci15091004

Bridging the gap in the management of Alzheimer's disease using fecal microbiota transplantation

Bushra Bashir, Monica Gulati, Sukriti Vishwas, Md Sadique Hussain, Gaurav Gupta, Puneet Kumar, Poonam Negi, Neeraj Mittal, Kamal Dua and Sachin Kumar Singh

Molecular and Cellular Neuroscience, 2025, 135, 104052
DOI: 10.1016/j.mcn.2025.104052

Measurement of synaptic density in Down syndrome using PET imaging: a pilot study

Alexandra DiFilippo, Erin Jonaitis, Renee Makuch, Brianna Gambetti, Victoria Fleming, Gilda Ennis, Todd Barnhart, Jonathan Engle, Barbara Bendlin, Sterling Johnson, Benjamin Handen, Sharon Krinsky-McHale, Sigan Hartley and Bradley Christian

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-54669-7

A sulfur-atom-enhanced strategy for NIR imaging of soluble and insoluble amyloid-β species

Xiaolei Zhao, Zhirong Zhu, Yiwei Wang, Minwei Sun, Na Li, Zhi Su and Wei Huang

Talanta, 2026, 302, 129417
DOI: 10.1016/j.talanta.2026.129417

Tolcapone Interferes With Key Pathological Features in Alzheimer’s Disease

Alessia Distefano, Damiano Calcagno, Giuseppe Grasso, Olivier Monasson, Elisa Peroni, Valentina Oliveri and Massimiliano F. Peana

Bioinorganic Chemistry and Applications, 2026, 2026
DOI: 10.1155/bca/1036276

Distribution in Rat Blood and Brain of TDMQ20, a Copper Chelator Designed as a Drug-Candidate for Alzheimer’s Disease

Lan Huang, Yaoxun Zeng, Yongliang Li, Yingshan Zhu, Yan He, Yan Liu, Anne Robert and Bernard Meunier

Pharmaceutics, 2022, 14, 2691
DOI: 10.3390/pharmaceutics14122691

Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks

Nikhil Dave, Jessica M. Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K. Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K. Winstone, Erik A. Blackwood, Christopher Glembotski, Timothy Karr and Ramon Velazquez

Aging Cell, 2023, 22
DOI: 10.1111/acel.13775

Metal Imbalance in Neurodegenerative Diseases with a Specific Concern to the Brain of Multiple Sclerosis Patients

Jean-Philippe Dales and Sophie Desplat-Jégo

IJMS, 2020, 21, 9105
DOI: 10.3390/ijms21239105

Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone

Rashik Ahmed, Jinfeng Huang, Daniel K. Weber, Tata Gopinath, Gianluigi Veglia, Madoka Akimoto, Adree Khondker, Maikel C. Rheinstädter, Vincent Huynh, Ryan G. Wylie, José C. Bozelli, Richard M. Epand and Giuseppe Melacini

J. Am. Chem. Soc., 2020
DOI: 10.1021/jacs.0c01894

A Flexible Bivalent Approach to Comprehensively Improve the Performances of Stilbazolium Dyes as Amyloid-β Fluorescent Probes

Zi-Min Zhuang, Zhe Zhou, Xian Chen, Xin-Ru Xu, Hang-Xing Wang and Jie Pan

ACS Appl. Mater. Interfaces, 2023, 15, 44742
DOI: 10.1021/acsami.3c09034

Nutraceuticals intervention in Alzheimer's disease: From farm to pharma

PM Chaithra, BS Rakshith, S Logesh, BM Kanthesh, TS Gopenath, Hung-Ming Chang, George Perry and Sandeep Kumar Singh

Journal of Alzheimer’s Disease, 2025, 108, 969
DOI: 10.1177/13872877251385216

Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane

Hebah Fatafta, Mohammed Khaled, Michael C. Owen, Abdallah Sayyed-Ahmad and Birgit Strodel

Proc. Natl. Acad. Sci. U.S.A., 2021, 118
DOI: 10.1073/pnas.2106210118

Amyloid β-Targeted Metal Complexes for Potential Applications in Alzheimer's Disease

Hao Liu, Yunwei Qu and Xiaohui Wang

Future Med. Chem., 2018, 10, 679
DOI: 10.4155/fmc-2017-0248

Ultrasmall Molybdenum Disulfide Quantum Dots Cage Alzheimer’s Amyloid Beta to Restore Membrane Fluidity

Yuhuan Li, Huayuan Tang, Houjuan Zhu, Aleksandr Kakinen, Di Wang, Nicholas Andrikopoulos, Yunxiang Sun, Aparna Nandakumar, Eunbi Kwak, Thomas P. Davis, David Tai Leong, Feng Ding and Pu Chun Ke

ACS Appl. Mater. Interfaces, 2021, 13, 29936
DOI: 10.1021/acsami.1c06478

A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review

Yang Gao, Sophia Schedin-Weiss and Lars O. Tjernberg

Advanced Technology in Neuroscience, 2024, 1, 177
DOI: 10.4103/ATN.ATN-D-24-00014

Copper imbalance in Alzheimer’s disease: Convergence of the chemistry and the clinic

Kasper P. Kepp and Rosanna Squitti

Coordination Chemistry Reviews, 2019, 397, 168
DOI: 10.1016/j.ccr.2019.06.018

Structural Dynamics of Amyloid-β Protofibrils and Actions of Anti-Amyloid-β Antibodies as Observed by High-Speed Atomic Force Microscopy

Takahiro Watanabe-Nakayama, Mayumi Tsuji, Kenichi Umeda, Tatsunori Oguchi, Hiroki Konno, Moeko Noguchi-Shinohara, Yuji Kiuchi, Noriyuki Kodera, David B. Teplow and Kenjiro Ono

Nano Lett., 2023, 23, 6259
DOI: 10.1021/acs.nanolett.3c00187

Two instantaneous fluorogenic steps for detection of nanomolar amyloid beta monomer and its interaction with stoichiometric copper(II) ion

Meenaxi Saini and Kalyan K. Sadhu

Sensors and Actuators B: Chemical, 2020, 303, 127086
DOI: 10.1016/j.snb.2019.127086

Chiroplasmon-active optical fiber probe for environment chirality estimation

Elena Miliutina, Jaroslav Zadny, Olga Guselnikova, Jan Storch, Hana Walaska, Anna Kushnarenko, Vasilii Burtsev, Vaclav Svorcik and Oleksiy Lyutakov

Sensors and Actuators B: Chemical, 2021, 343, 130122
DOI: 10.1016/j.snb.2021.130122

Interference with Amyloid-β Nucleation by Transient Ligand Interaction

Tao Zhang, Jennifer Loschwitz, Birgit Strodel, Luitgard Nagel-Steger and Dieter Willbold

Molecules, 2019, 24, 2129
DOI: 10.3390/molecules24112129

Pathophysiological mechanism and natural preventive and therapeutic strategies of Alzheimer's disease

Abdelkader Basli and Jihane Bounaas

Nutr Health, 2023, 29, 403
DOI: 10.1177/02601060221137104

Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation

Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow and Kenjiro Ono

Neurobiology of Disease, 2025, 205, 106775
DOI: 10.1016/j.nbd.2024.106775

Strategies Targeting Soluble β-Amyloid Oligomers and their Application to Early Diagnosis of Alzheimer’s Disease

Fantian Zeng, Yuyan Li , Yungen Xu, Jian Yang, Zhengshi Liu, Xiaofang Li and Longfei Ren

CAR, 2020, 16, 1132
DOI: 10.2174/1567205016666191031163504

Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review

Pinky Gehlot, Sunil Kumar, Vivek Kumar Vyas, Bhanwar Singh Choudhary, Manish Sharma and Ruchi Malik

Bioorganic & Medicinal Chemistry, 2022, 74, 117047
DOI: 10.1016/j.bmc.2022.117047

The influences of E22Q mutant on solvated 3Aβ11-40 peptide: A REMD study

Son Tung Ngo, Huynh Minh Hung, Nam Dao Hong and Nguyen Thanh Tung

Journal of Molecular Graphics and Modelling, 2018, 83, 122
DOI: 10.1016/j.jmgm.2018.06.002

Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

Steven S. Plotkin and Neil R. Cashman

Neurobiology of Disease, 2020, 144, 105010
DOI: 10.1016/j.nbd.2020.105010

Increased Release of Apolipoprotein E in Extracellular Vesicles Following Amyloid-β Protofibril Exposure of Neuroglial Co-Cultures

Elisabeth Nikitidou, Payam Emami Khoonsari, Ganna Shevchenko, Martin Ingelsson, Kim Kultima and Anna Erlandsson

JAD, 2017, 60, 305
DOI: 10.3233/JAD-170278

Amyloid Growth, Inhibition, and Real-Time Enzymatic Degradation Revealed with Single Conical Nanopore

Nicoletta Giamblanco, Diego Coglitore, Alberto Gubbiotti, Tianji Ma, Emmanuel Balanzat, Jean-Marc Janot, Mauro Chinappi and Sebastien Balme

Anal. Chem., 2018, 90, 12900
DOI: 10.1021/acs.analchem.8b03523

Active Site Environment and Reactivity of Copper‐Aβ in Membrane Mimetic SDS Micellar Environment

Chinmay Dey, Madhuparna Roy, Rimi Ghosh, Puja Pal, Debapriyo Roy and Somdatta Ghosh Dey

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401531

Targeting STAT3 in Alzheimer's disease: Potential mechanisms and therapeutic implications

Peixian Chen, Rui Wang, Ting Zhou, Yi Sun, Frank Kirchhoff, Zhenyuan Miao and Chunlin Zhuang

European Journal of Medicinal Chemistry, 2026, 310, 118785
DOI: 10.1016/j.ejmech.2026.118785

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan and Yaping Chen

Advanced Therapeutics, 2025, 8
DOI: 10.1002/adtp.202500124

Investigating the geometrical preferences of a flexible benzimidazolone-based linker in the synthesis of coordination polymers

Corey L. Jones, Elizabeth A. Marsden, Adam C. Nevin, Benson M. Kariuki, Mohan M. Bhadbhade, Adam D. Martin and Timothy L. Easun

R. Soc. open sci., 2017, 4, 171064
DOI: 10.1098/rsos.171064

Metal-involved theranostics: An emerging strategy for fighting Alzheimer’s disease

Xiaohui Wang, Xiaoyong Wang and Zijian Guo

Coordination Chemistry Reviews, 2018, 362, 72
DOI: 10.1016/j.ccr.2018.03.010

Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity

Kolla Rajasekhar, Sourav Samanta, Vardhaman Bagoband, N. Arul Murugan and Thimmaiah Govindaraju

iScience, 2020, 23, 101005
DOI: 10.1016/j.isci.2020.101005

RETRACTED: Cytotoxic Effect of Amyloid-β1-42 Oligomers on Endoplasmic Reticulum and Golgi Apparatus Arrangement in SH-SY5Y Neuroblastoma Cells

José Jarero-Basulto, Yadira Gasca-Martínez, Martha Rivera-Cervantes, Deisy Gasca-Martínez, Nidia Carrillo-González, Carlos Beas-Zárate and Graciela Gudiño-Cabrera

NeuroSci, 2024, 5, 141
DOI: 10.3390/neurosci5020010

Organoplatinum‐Substituted Polyoxometalate Inhibits β‐amyloid Aggregation for Alzheimer's Therapy

Jing Zhao, Kexin Li, Kaiwei Wan, Tiedong Sun, Nannan Zheng, Fanjiao Zhu, Jichao Ma, Jia Jiao, Tianchan Li, Jinyuan Ni, Xinghua Shi, Hui Wang, Qiang Peng, Jing Ai, Wanhai Xu and Shaoqin Liu

Angew Chem Int Ed, 2019, 58, 18032
DOI: 10.1002/anie.201910521

Etersalate prevents the formations of 6Aβ16-22 oligomer: An in silico study

Son Tung Ngo, Xuan-Cuong Luu, Nguyen Thanh Nguyen, Van Van Vu, Huong Thi Thu Phung and Pedro Fernandez-Funez

PLoS ONE, 2018, 13, e0204026
DOI: 10.1371/journal.pone.0204026

Solution‐Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies

Tao Zhang, Luitgard Nagel‐Steger and Dieter Willbold

ChemistryOpen, 2019, 8, 989
DOI: 10.1002/open.201900167

Targeting Pathological Amyloid Aggregates with Conformation-Sensitive Antibodies

Alessandra Bigi, Gilda Loffredo, Roberta Cascella and Cristina Cecchi

CAR, 2020, 17, 722
DOI: 10.2174/1567205017666201109093848

Identification of new pentapeptides as potential inhibitors of amyloid–β42 aggregation using virtual screening and molecular dynamics simulations

Apneet Kaur and Bhupesh Goyal

Journal of Molecular Graphics and Modelling, 2023, 124, 108558
DOI: 10.1016/j.jmgm.2023.108558

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments

Qing Yang, Jianan Lin, Huiyuan Zhang, Yingna Liu, Mo Kan, Zhiru Xiu, Xijun Chen, Xingcheng Lan, Xiaohua Li, Xiaozheng Shi, Na Li and Xiaobo Qu

J Mol Neurosci, 2019, 67, 62
DOI: 10.1007/s12031-018-1210-3

Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase

Piotr Hanczyc and Piotr Fita

ACS Photonics, 2021, 8, 2598
DOI: 10.1021/acsphotonics.1c00082

Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ42 Oligomers

Liang Sun, Anuj K. Sharma, Byung-Hee Han and Liviu M. Mirica

ACS Chem. Neurosci., 2020, 11, 2741
DOI: 10.1021/acschemneuro.0c00376

Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020)

Xuefei Li, Yanbo Yu and Zhude Tu

Molecules, 2021, 26, 1202
DOI: 10.3390/molecules26051202

Molecular Mechanisms of Inhibition of Protein Amyloid Fibril Formation: Evidence and Perspectives Based on Kinetic Models

Igor Sedov and Diliara Khaibrakhmanova

IJMS, 2022, 23, 13428
DOI: 10.3390/ijms232113428

Dual O2-Mediated Reactivity of a Mononuclear Cobalt Complex with Amyloid-β Peptides

Jong-Min Suh, Wooyeol Ryu, Eunju Nam, Nam Kwon, Kyungmin Kim, Dongwook Kim, Jaeheung Cho, Kiyoung Park and Mi Hee Lim

ACS Catal., 2024, 14, 14497
DOI: 10.1021/acscatal.4c02303

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

Joana Saavedra, Mariana Nascimento, António J. Figueira, Marina I. Oliveira da Silva, Tiago Gião, João Oliveira, Márcia A. Liz, Cláudio M. Gomes and Isabel Cardoso

Front. Mol. Neurosci., 2025, 18
DOI: 10.3389/fnmol.2025.1636365

Combination of p-coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice

Yan Zhou, Yitian Sun, Hui Guo, Yanzi Liang, Siyuan Zhu, Yu Sha, Zhongxiao Wan, Jiaying Xu, Jianrong Jiang, Liqiang Qin and Yunhong Li

Food Science and Human Wellness, 2025, 14, 9250164
DOI: 10.26599/FSHW.2024.9250164

Efficacy and safety of blood derivatives therapy in Alzheimer’s disease: a systematic review and meta-analysis

Zhangcheng Fei, Bo Pan, Renjun Pei, Zhongsheng Chen, Xi Du, Haijun Cao and Changqing Li

Syst Rev, 2022, 11
DOI: 10.1186/s13643-022-02115-y

Autoxidation Enhances Anti-Amyloid Potential of Flavone Derivatives

Andrius Sakalauskas, Mantas Ziaunys, Ruta Snieckute and Vytautas Smirnovas

Antioxidants, 2021, 10, 1428
DOI: 10.3390/antiox10091428

The functional role of Ire1 in regulating autophagy and proteasomal degradation under prolonged proteotoxic stress

Eshita Das, Kiran Kumari Sahu and Ipsita Roy

The FEBS Journal, 2023, 290, 3270
DOI: 10.1111/febs.16747

Binary Structure of Amyloid Beta Oligomers Revealed by Dual Recognition Mapping

Jihyun Yoon, Youngkyu Kim and Joon Won Park

Anal. Chem., 2019, 91, 8422
DOI: 10.1021/acs.analchem.9b01316

Electrical characteristics of amyloid beta peptides in vertical junctions

Sohyeon Seo, Jinju Lee, Jungsue Choi, G. Hwan Park, Yeseul Hong and Hyoyoung Lee

NPG Asia Mater, 2021, 13
DOI: 10.1038/s41427-021-00321-z

Insights into the Molecular Mechanisms of Alzheimer’s and Parkinson’s Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology

Orkid Coskuner-Weber and Vladimir Uversky

IJMS, 2018, 19, 336
DOI: 10.3390/ijms19020336

Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring of Amyloid-β Aggregation

Sonam Kim, Hyuck Jin Lee, Eunju Nam, Donghyun Jeong, Jaeheung Cho, Mi Hee Lim and Youngmin You

ACS Omega, 2018, 3, 5141
DOI: 10.1021/acsomega.8b00286

Biflavonoid-Induced Disruption of Hydrogen Bonds Leads to Amyloid-β Disaggregation

Peter K. Windsor, Stephen P. Plassmeyer, Dominic S. Mattock, Jonathan C. Bradfield, Erika Y. Choi, Bill R. Miller and Byung Hee Han

IJMS, 2021, 22, 2888
DOI: 10.3390/ijms22062888

A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer’s Disease

Hong-Jun Cho, Anuj K. Sharma, Ying Zhang, Michael L. Gross and Liviu M. Mirica

ACS Chem. Neurosci., 2020, 11, 1471
DOI: 10.1021/acschemneuro.0c00114

Design of Red Fluorescence Ce-Based Carbon Dots of High and Balanced Multiple Functions against Alzheimer’s β-Amyloid Fibrillization

Zitong Wei, Xiaoyan Dong and Yan Sun

ACS Appl. Mater. Interfaces, 2025, 17, 49737
DOI: 10.1021/acsami.5c10137

Strategic Design of 2,2′-Bipyridine Derivatives to Modulate Metal–Amyloid-β Aggregation

Yonghwan Ji, Hyuck Jin Lee, Minjeong Kim, Geewoo Nam, Shin Jung C. Lee, Jaeheung Cho, Cheol-Min Park and Mi Hee Lim

Inorg. Chem., 2017, 56, 6695
DOI: 10.1021/acs.inorgchem.7b00782

Natural Polyphenolic Nanodots for Alzheimer's Disease Treatment

Peng Yang, Qianqian Huang, Jianhua Zhang, Yiwen Li, Huile Gao and Zhipeng Gu

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202308393

All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease

Yi-Yao Liang, Li-Dan Zhang, Xi Luo, Li-Li Wu, Zhao-Wei Chen, Guang-Hao Wei, Kai-Qing Zhang, Ze-An Du, Ren-Zhi Li, Kwok-Fai So and Ang Li

Neural Regen Res, 2022, 17, 1210
DOI: 10.4103/1673-5374.325012

Distinct Aggregation Behavior of N-Terminally Truncated Aβ4–42 Over Aβ1–42 in the Presence of Zn(II)

Chanju Na, Mingeun Kim, Gunhee Kim, Yuxi Lin, Young-Ho Lee, Wojciech Bal, Eunju Nam and Mi Hee Lim

ACS Chem. Neurosci., 2025, 16, 732
DOI: 10.1021/acschemneuro.4c00831

Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus

Juan Huang, Nanqu Huang, Qianhua Mao, Jingshan Shi and Yu Qiu

Front. Aging Neurosci., 2023, 15
DOI: 10.3389/fnagi.2023.1130253

Zunyimycin C enhances immunity and improves cognitive impairment and its mechanism

Xuemei Wang, Zexin Li, Rui Sun, Xueli Li, Ruirui Guo, Xiangyi Cui, Bingxin Liu, Wujuan Li, Yi Yang, Xiaoyu Huang, Hanlin Qu, Chen Liu, Zhuoling Wang, Yuhong Lü and Changwu Yue

Front. Cell. Infect. Microbiol., 2022, 12
DOI: 10.3389/fcimb.2022.1081243

New horizons in the diagnosis and management of Alzheimer’s Disease in older adults

Helena Dolphin, Adam H Dyer, Laura Morrison, Susan D Shenkin, Tomas Welsh and Sean P Kennelly

Age and Ageing, 2024, 53
DOI: 10.1093/ageing/afae005

Metal Ions in Alzheimer’s Disease: A Key Role or Not?

Yan Liu, Michel Nguyen, Anne Robert and Bernard Meunier

Acc. Chem. Res., 2019, 52, 2026
DOI: 10.1021/acs.accounts.9b00248

Functionalized Upconversion Nanoparticles for Disassembly of β‑Amyloid Aggregation with Near-Infrared Excitation

Ju Huang, Zhen Li and Zhihong Liu

Acta Chimica Sinica, 2021, 79, 1049
DOI: 10.6023/A21050194

Development and evolution of human glutaminyl cyclase inhibitors (QCIs): an alternative promising approach for disease-modifying treatment of Alzheimer's disease

Daoyuan Chen, Qingxiu Chen, Xiaofei Qin, Peipei Tong, Liping Peng, Tao Zhang and Chunli Xia

Front. Aging Neurosci., 2023, 15
DOI: 10.3389/fnagi.2023.1209863

Oxidative Stress Boosts the Uptake of Cerium Oxide Nanoparticles by Changing Brain Endothelium Microvilli Pattern

Roberta Dal Magro, Agostina Vitali, Stefano Fagioli, Alberto Casu, Andrea Falqui, Beatrice Formicola, Lorenzo Taiarol, Valeria Cassina, Claudia Adriana Marrano, Francesco Mantegazza, Umberto Anselmi-Tamburini, Patrizia Sommi and Francesca Re

Antioxidants, 2021, 10, 266
DOI: 10.3390/antiox10020266

Neural Stem Cell-conditioned Medium Protected Against Cognitive Dysfunction in APP/PS1 Mice

Xiaoyu Zheng, Qian Xiang, Xiaoxu Dong, Yang Shen, Tingyu Qu, Wei Fang and Hongna Yang

Mol Neurobiol, 2026, 63
DOI: 10.1007/s12035-025-05282-w

Strategies for Inhibition and Disaggregation of Amyloid‐β Fibrillation

Hao Geng, Dong Gao, Zijuan Wang, Xiaoning Liu, Zhanshuo Cao and Chengfen Xing

Chin. J. Chem., 2022, 40, 524
DOI: 10.1002/cjoc.202100646

The Promising Role of Selenium and Yeast in the Fight Against Protein Amyloidosis

Marek Kieliszek and Katsiaryna Sapazhenkava

Biol Trace Elem Res, 2025, 203, 1251
DOI: 10.1007/s12011-024-04245-x

Post-Translational Modifications of BACE1 in Alzheimer's Disease

Wen Wen, Ping Li, Panwang Liu, Shijun Xu, Fushun Wang and Jason H Huang

CN, 2022, 20, 211
DOI: 10.2174/1570159X19666210121163224

An approach to predict and inhibit Amyloid Beta dimerization pattern in Alzheimer’s disease

Sreekanya Roy, Sima Biswas, Anirban Nandy, Dipanjan Guha, Rakhi Dasgupta, Angshuman Bagchi and Parames Chandra Sil

Toxicology Reports, 2025, 14, 101879
DOI: 10.1016/j.toxrep.2024.101879

Redox Properties of Small Molecules Essential for Multiple Reactivities with Pathological Factors in Alzheimer's Disease

Mingeun Kim and Mi Hee Lim

Bulletin Korean Chem Soc, 2021, 42, 1272
DOI: 10.1002/bkcs.12372

Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non‐human primate models

Zhihui Jin, Yan Lu, Huifang Tang and Huashun Cui

Alzheimer's & Dementia, 2025, 21
DOI: 10.1002/alz.70472

Early Detection of Alzheimer’s Disease via Amyloid Aggregates: A Systematic Review of Plasma Spectral Biomarkers and Machine Learning Approaches

Stella Hernández, Sonia M. Valladares-Rodríguez, Mercedes Novo and Wajih Al-Soufi

JDAD, 2025, 2, 38
DOI: 10.3390/jdad2040038

Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal 15N–R2 Correlation Matrices

Rashik Ahmed, Jinfeng Huang, Madoka Akimoto, Tongyu Shi and Giuseppe Melacini

J. Am. Chem. Soc., 2021, 143, 4668
DOI: 10.1021/jacs.0c13289

Identification of a Novel Multifunctional Ligand for Simultaneous Inhibition of Amyloid-Beta (Aβ42) and Chelation of Zinc Metal Ion

Mohsen Asadbegi and Amir Shamloo

ACS Chem. Neurosci., 2019, 10, 4619
DOI: 10.1021/acschemneuro.9b00468

Interaction studies of oxindole-derivatives with β-amyloid peptides inhibiting its aggregation induced by metal ions

Camila Anchau Wegermann, Valentina Pirota, Enrico Monzani, Luigi Casella, Luiz Antônio Sodré Costa, Willian Tássio Gomes Novato, M. Teresa Machini and Ana Maria da Costa Ferreira

Journal of Inorganic Biochemistry, 2023, 245, 112227
DOI: 10.1016/j.jinorgbio.2023.112227

Critical aggregation concentration and reversibility of amyloid-β (1–40) oligomers

Sara Illodo, Wajih Al-Soufi and Mercedes Novo

Archives of Biochemistry and Biophysics, 2024, 761, 110179
DOI: 10.1016/j.abb.2024.110179

Characterization of Uranyl (UO22+) Ion Binding to Amyloid Beta (Aβ) Peptides: Effects on Aβ Structure and Aggregation

Elina Berntsson, Faraz Vosough, Andra Noormägi, Kärt Padari, Fanny Asplund, Maciej Gielnik, Suman Paul, Jüri Jarvet, Vello Tõugu, Per M. Roos, Maciej Kozak, Astrid Gräslund, Andreas Barth, Margus Pooga, Peep Palumaa and Sebastian K. T. S. Wärmländer

ACS Chem. Neurosci., 2023, 14, 2618
DOI: 10.1021/acschemneuro.3c00130

Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization

Cecilia Wallin, Merlin Friedemann, Sabrina B. Sholts, Andra Noormägi, Teodor Svantesson, Jüri Jarvet, Per M. Roos, Peep Palumaa, Astrid Gräslund and Sebastian K. T. S. Wärmländer

Biomolecules, 2019, 10, 44
DOI: 10.3390/biom10010044

AFM Probing of Amyloid-Beta 42 Dimers and Trimers

Sibaprasad Maity and Yuri L. Lyubchenko

Front. Mol. Biosci., 2020, 7
DOI: 10.3389/fmolb.2020.00069

De novo design of a mechano-pharmaceutical screening platform against formation of individual beta-amyloid oligomers

Shankar Pandey, Mathias Bogetoft Danielsen, Yuan Xiang, Zhilei Zhang, Grinsun Sharma, Byeong Tak Jeon, Shixi Song, Yitong Hao, Gunan Zhang, Niels Johan Christensen, Kasper Kildegaard Sørensen, Pernille Harris, Pravin Pokhrel, Richard Cunningham, Min-Ho Kim, Yongsheng Leng, Chenguang Lou and Hanbin Mao

Cell Reports Physical Science, 2024, 5, 102336
DOI: 10.1016/j.xcrp.2024.102336

A multifunctional theranostic agent based on rhodamine-modified copper-gallic acid nanoparticles targeting Alzheimer’s β‑amyloid species

Luqi Liu, Wei Liu, Xiaoyan Dong and Yan Sun

Chemical Engineering Journal, 2025, 513, 163063
DOI: 10.1016/j.cej.2025.163063

Aggregation Propensities of Herpes Simplex Virus-1 Proteins and Derived Peptides: An In Silico and In Vitro Analysis

Vikas Kumar Singh, Sandeep Kumar and Suman Tapryal

ACS Omega, 2020, 5, 12964
DOI: 10.1021/acsomega.0c00730

Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer’s Disease

Jiyeon Han, Zhi Du and Mi Hee Lim

Acc. Chem. Res., 2021, 54, 3930
DOI: 10.1021/acs.accounts.1c00457

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease

Anna E. Bugrova, Polina A. Strelnikova, Maria I. Indeykina, Alexey S. Kononikhin, Natalia V. Zakharova, Alexander G. Brzhozovskiy, Evgeny P. Barykin, Stanislav I. Pekov, Maria S. Gavrish, Alexey A. Babaev, Anna M. Kosyreva, Anna Y. Morozova, Daniil A. Degterev, Vladimir A. Mitkevich, Igor A. Popov, Alexander A. Makarov and Evgeny N. Nikolaev

IJMS, 2021, 23, 27
DOI: 10.3390/ijms23010027

Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: recent advances and perspectives

Shuzhen Fang, Kangyi Zhang, Danqing Liu, Yulong Yang, Hu Xi, Wenting Xie, Ke Diao, Zhihong Rao, Dongxu Wang and Wenming Yang

Front. Nutr., 2024, 11
DOI: 10.3389/fnut.2024.1408620

The involvement of amyloid‐β in the central nervous system regulation underlying sleep deprivation‐induced rapid ejaculation in rats

Peng Yang, Tianle Zhu, Yukuai Ma, Zhi Cao, Pan Gao, Hui Jiang and Xiansheng Zhang

Andrology, 2025, 13, 1958
DOI: 10.1111/andr.13826

Isomeric Effect of Nano-Inhibitors on Aβ40 Fibrillation at The Nano-Bio Interface

Jianhang Li, Guanbin Gao, Xintong Tang, Meng Yu, Meng He and Taolei Sun

ACS Appl. Mater. Interfaces, 2021, 13, 4894
DOI: 10.1021/acsami.0c21906

Binding to Amyloid‐β Protein by Photothermal Blood‐Brain Barrier‐Penetrating Nanoparticles for Inhibition and Disaggregation of Fibrillation

Hao Geng, Yu‐chen Pan, Ran Zhang, Dong Gao, Zijuan Wang, Boying Li, Ning Li, Dong‐sheng Guo and Chengfen Xing

Adv Funct Materials, 2021, 31
DOI: 10.1002/adfm.202102953

Triazole–Peptide Conjugate as a Modulator of Aβ-Aggregation, Metal-Mediated Aβ-Aggregation, and Cytotoxicity

Sukhmani Mann, Anupamjeet Kaur, Amandeep Kaur, Nitesh Priyadarshi, Bhupesh Goyal, Nitin Kumar Singhal and Deepti Goyal

ACS Chem. Neurosci., 2023, 14, 1631
DOI: 10.1021/acschemneuro.3c00041

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko and Anna I. Sulatskaya

Aggregate, 2025, 6
DOI: 10.1002/agt2.70078

Insights into the Assembly of Peptides Catalyzed by Polysaccharides

Wang Li, Yang Zhou, Xinran Zhang, Sheng He, Liulin Yang, Xiaoyu Cao and Zhong-Qun Tian

J. Phys. Chem. B, 2025, 129, 487
DOI: 10.1021/acs.jpcb.4c05751

Transition Metal Ion FRET-Based Probe to Study Cu(II)-Mediated Amyloid-β Ligand Binding

Ri Wu, Despoina Svingou, Jonas B. Metternich, Lukas R. Benzenberg and Renato Zenobi

J. Am. Chem. Soc., 2024, 146, 2102
DOI: 10.1021/jacs.3c11533

Amyloid structures: much more than just a cross-β fold

Rodrigo Gallardo, Neil A Ranson and Sheena E Radford

Current Opinion in Structural Biology, 2020, 60, 7
DOI: 10.1016/j.sbi.2019.09.001

Chiral ZnO Nanoparticles Synergistically Inhibiting Fibrillization and Disaggregating of Amyloid-β Fibrils for Attenuation Neurotoxicity

Yaojing He, Xiaoyu Zhao, Yurong Han, Lie Wu, Hongda Wang and Xiue Jiang

Chem. Res. Chin. Univ., 2026
DOI: 10.1007/s40242-026-5293-z

Identification of E3 Ubiquitin Ligase Substrates Using Biotin Ligase-Based Proximity Labeling Approaches

Koji Matsuhisa, Shinya Sato and Masayuki Kaneko

Biomedicines, 2025, 13, 854
DOI: 10.3390/biomedicines13040854

Structural determinants of the interactions of catechins with Aβ oligomers and lipid membranes

Rashik Ahmed, Jinfeng Huang, Romi Lifshitz, Karla Martinez Pomier and Giuseppe Melacini

Journal of Biological Chemistry, 2022, 298, 101502
DOI: 10.1016/j.jbc.2021.101502

Intercommunication between metal ions and amyloidogenic peptides or proteins in protein misfolding disorders

Jong-Min Suh, Mingeun Kim, Jeasang Yoo, Jiyeon Han, Cinthya Paulina and Mi Hee Lim

Coordination Chemistry Reviews, 2023, 478, 214978
DOI: 10.1016/j.ccr.2022.214978

The relationship between hypoxia and Alzheimer’s disease: an updated review

Borui Tao, Wei Gong, Chengyuan Xu, Zhihui Ma, Jinyu Mei and Ming Chen

Front. Aging Neurosci., 2024, 16
DOI: 10.3389/fnagi.2024.1402774

A Luminescence-Based System for Identification of Genetically Encodable Inhibitors of Protein Aggregation

Travis J. Nelson, Shuo Liang and Cliff I. Stains

ACS Omega, 2020, 5, 12974
DOI: 10.1021/acsomega.0c00779

Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid β metabolism

Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao and Mei-Na Wu

Neurobiology of Aging, 2023, 124, 71
DOI: 10.1016/j.neurobiolaging.2023.01.008

Disorder-to-order transition of the amyloid-β peptide upon lipid binding

Hebah Fatafta, Batuhan Kav, Bastian F. Bundschuh, Jennifer Loschwitz and Birgit Strodel

Biophysical Chemistry, 2022, 280, 106700
DOI: 10.1016/j.bpc.2021.106700

Rational design of hydroxytricyanopyrrole-based probes with high affinity and rapid visualization for amyloid-β aggregates in vitro and in vivo

Jiajia Lv, Jie Gao, Hongyu Li, Zeli Yuan and Nan Dong

Chinese Chemical Letters, 2024, 35, 108940
DOI: 10.1016/j.cclet.2023.108940

Alzheimer’s disease: risk factors and potentially protective measures

Marcos Vinícius Ferreira Silva, Cristina de Mello Gomide Loures, Luan Carlos Vieira Alves, Leonardo Cruz de Souza, Karina Braga Gomes Borges and Maria das Graças Carvalho

J Biomed Sci, 2019, 26
DOI: 10.1186/s12929-019-0524-y

Creating an Amyloid ‘Kaleidoscope’ Using Short Iodinated Peptides

Danni Li, Yeyang Ma, Wencheng Xia, Youqi Tao, Yiling Zhang, Hong Zhang, Dan Li, Bin Dai and Cong Liu

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202310737

Molecular dynamics simulations of lysozyme–lipid systems: probing the early steps of protein aggregation

Valeriya M. Trusova and Galyna P. Gorbenko

Journal of Biomolecular Structure and Dynamics, 2018, 36, 2249
DOI: 10.1080/07391102.2017.1349691

Aβ Beyond the AD Pathology: Exploring the Structural Response of Membranes Exposed to Nascent Aβ Peptide

Valeria Rondelli, Mario Salmona, Laura Colombo, Giovanna Fragneto, Giulia C. Fadda, Laura Cantu’ and Elena Del Favero

IJMS, 2020, 21, 8295
DOI: 10.3390/ijms21218295

Suppression of Astrocytic PirB Alleviates Aβ‐Induced Excitotoxicity and Cognitive Deficits via EAAT Expression

Xiaohua Zhang, Yuanjie Zhao, Xinlin Chen, Wenhua Shen, Li Huang and Tao Tan

Glia, 2026, 74
DOI: 10.1002/glia.70130

Mass spectrometric studies of the variety of beta‐amyloid proteoforms in Alzheimer's disease

Natalia V. Zakharova, Alexey S. Kononikhin, Maria I. Indeykina, Anna E. Bugrova, Polina Strelnikova, Stanislav Pekov, Sergey A. Kozin, Igor A. Popov, Vladimir Mitkevich, Alexander A. Makarov and Evgeny N. Nikolaev

Mass Spectrometry Reviews, 2025, 44, 3
DOI: 10.1002/mas.21775

Synthesis, Single Crystal Characterization and Anti-AD Activities of a Novel Complex of Cu(II) with in Situ Formed Protonated Chrysin Derivative Ligand

Chang Liu, Jianhua Wu, Chengting Hu, Aihong Yang, Rui Shen and Xiaodi Kou

SSRN Journal, 2022
DOI: 10.2139/ssrn.4199898

Modulation of β secretase and neuroinflammation by biomimetic nanodelivery system for Alzheimer's disease therapy

Xiaolei Song, Chenchen Wang, Qin Ding, Peng Li, Shihao Sun, Wei Wei, Juan Zhang, Rongli Sun, Lihong Yin, Songqin Liu and Yuepu Pu

Journal of Controlled Release, 2025, 378, 735
DOI: 10.1016/j.jconrel.2024.12.060

New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation

Cong Liu and Yanshan Fang

Biochemical Pharmacology, 2019, 167, 58
DOI: 10.1016/j.bcp.2019.04.028

Aβ8-20 Fragment as an Anti-Fibrillogenic and Neuroprotective Agent: Advancing toward Efficient Alzheimer’s Disease Treatment

Stefania Zimbone, Maria Laura Giuffrida, Giuseppina Sabatino, Giuseppe Di Natale, Rita Tosto, Grazia M. L. Consoli, Danilo Milardi, Giuseppe Pappalardo and Michele F.M. Sciacca

ACS Chem. Neurosci., 2023, 14, 1126
DOI: 10.1021/acschemneuro.2c00720

Brain Microvascular Endothelial Cell Derived Exosomes Potently Ameliorate Cognitive Dysfunction by Enhancing the Clearance of Aβ Through Up-Regulation of P-gp in Mouse Model of AD

Junlu Pan, Ruyi He, Qinghao Huo, Yijie Shi and Liang Zhao

Neurochem Res, 2020, 45, 2161
DOI: 10.1007/s11064-020-03076-1

Dual modulators of aggregation and dissociation of amyloid beta and tau: In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components

Sujin Kim, Yunkwon Nam, Soo Jung Shin, Ritu Prajapati, Seong Min Shin, Min-Jeong Kim, Hyeon soo Kim, Seol Hwa Leem, Tae-Jin Kim, Yong Ho Park, Jwa-Jin Kim, Jae Sue Choi and Minho Moon

Biomedicine & Pharmacotherapy, 2022, 156, 113865
DOI: 10.1016/j.biopha.2022.113865

Congo Red‐Derived Carbon Dots: Simultaneously as Fluorescence Probe for Protein Aggregates, Inhibitor for Protein Aggregation, and Scavenger of Free Radicals

Qin‐ying Li, Xu Yu, Xi Li, Li‐na Bao, Yu Zhang, Shi‐lin Wang, Ming Jiang, Kun Huang and Li Xu

Small, 2023, 19
DOI: 10.1002/smll.202205634

GFP-based red-emissive fluorescent probes for dual imaging of β-amyloid plaques and mitochondrial viscosity

Huaxiang Leng, Jinrong Yang, Liansheng Long, Yiyong Yan, Wen-Jing Shi, Lei Zhang and Jin-wu Yan

Bioorganic Chemistry, 2023, 136, 106540
DOI: 10.1016/j.bioorg.2023.106540

Molecular mechanism of Alzheimer’s β-amyloid peptide aggregation

Yanyan Li, Xiwen Mao, Keyu Liu and Zheng Niu

Chin. Sci. Bull., 2024
DOI: 10.1360/TB-2023-1167

Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws

Alexandra Silva, Zsuzsa Sárkány, Joana S. Fraga, Pablo Taboada, Sandra Macedo-Ribeiro and Pedro M. Martins

Biomolecules, 2018, 8, 108
DOI: 10.3390/biom8040108

Asiatic acid and its derivatives: Pharmacological insights and applications

Chaowei Liang, Yongzhi Ma, Minni Ding, Fang Gao, Kewang Yu, Siyu Wang, Ying Qu, Huiming Hua and Dahong Li

European Journal of Medicinal Chemistry, 2025, 289, 117429
DOI: 10.1016/j.ejmech.2025.117429

Aβ-oligomers: A potential therapeutic target for Alzheimer's disease

Sudeshna Ghosh, Rafat Ali and Sandeep Verma

International Journal of Biological Macromolecules, 2023, 239, 124231
DOI: 10.1016/j.ijbiomac.2023.124231

Revisiting the earliest signatures of amyloidogenesis: Roadmaps emerging from computational modeling and experiment

Shayon Bhattacharya, Liang Xu and Damien Thompson

WIREs Comput Mol Sci, 2018, 8
DOI: 10.1002/wcms.1359

Light‐controlled molecular tweezers capture specific amyloid oligomers

Chengyuan Qian, Jiefang Chen, Cheng Wang, Qiang Wang, Xiaoyong Wang and Xiaohui Wang

Aggregate, 2024, 5
DOI: 10.1002/agt2.463

Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-β in the Extracellular Region

Tae Su Choi, Hyuck Jin Lee, Jong Yoon Han, Mi Hee Lim and Hugh I. Kim

J. Am. Chem. Soc., 2017, 139, 15437
DOI: 10.1021/jacs.7b08584

Functional Amyloids: Where Supramolecular Amyloid Assembly Controls Biological Activity or Generates New Functionality

Jessica A. Buchanan, Nikhil R. Varghese, Caitlin L. Johnston and Margaret Sunde

Journal of Molecular Biology, 2023, 435, 167919
DOI: 10.1016/j.jmb.2022.167919

Aspartic Acid-Assisted Size-Controllable Synthesis of Nanoscale Spherical Covalent Organic Frameworks with Chiral Interfaces for Inhibiting Amyloid-β Fibrillation

Kai-Xiang Gao, Zhe Zhou, Linli Yao, Suxiao Wang, Yuexing Zhang, Qichao Zou, Li-Xin Ma and Hang-Xing Wang

ACS Appl. Bio Mater., 2022, 5, 1210
DOI: 10.1021/acsabm.1c01245

Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity

Mingeun Kim, Yuxi Lin, Eunju Nam, Dong Min Kang, Sungsu Lim, Yun Kyung Kim, Young-Ho Lee and Mi Hee Lim

Nat Chem Biol, 2025, 21, 1709
DOI: 10.1038/s41589-025-01987-0

Amyloid-β aggregates-restricted rotational motion amplifies photo-catalytic activity from quinolinium derivatives

Hua Liu, Yiliang Li, Lin Wei, Zhongju Ye, Jie Yuan and Lehui Xiao

Nano Today, 2024, 58, 102434
DOI: 10.1016/j.nantod.2024.102434

Why Is Tetradentate Coordination Essential for Potential Copper Homeostasis Regulators in Alzheimer's Disease?

Youzhi Li, Michel Nguyen, Morgane Baudoin, Laure Vendier, Yan Liu, Anne Robert and Bernard Meunier

Eur J Inorg Chem, 2019, 2019, 4712
DOI: 10.1002/ejic.201900951

Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway

Qing-Qing Xu, Zi-Ren Su, Wen Yang, Mei Zhong, Yan-Fang Xian and Zhi-Xiu Lin

J Neuroinflammation, 2023, 20
DOI: 10.1186/s12974-023-02704-1

Fluid biomarkers for the diagnosis of neurodegenerative diseases

Matthew Luebke, Manisha Parulekar and Florian P. Thomas

Biomarkers in Neuropsychiatry, 2023, 8, 100062
DOI: 10.1016/j.bionps.2023.100062

The Features of Beta-Amyloid Phosphorylation in Alzheimer’s Disease

P A. Strelnikova, A. E. Bugrova, N. V. Zakharova, K. V. Danichkina, M. I. Indeykina, M. S. Gavrish, V. G. Krut, A. A. Babaev, A. Yu. Morozova, A. S. Kononikhin, V. A. Mitkevich, A. A. Makarov and E. N. Nikolaev

Acta Naturae, 2024, 16, 93
DOI: 10.32607/actanaturae.27456

Current amyloid inhibitors: Therapeutic applications and nanomaterial-based innovations

Paula López-García, María M. Tejero-Ojeda, María Eugenia Vaquero and Mariano Carrión-Vázquez

Progress in Neurobiology, 2025, 247, 102734
DOI: 10.1016/j.pneurobio.2025.102734

Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-β complexes

Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Geewoo Nam, Junghyun Chae and Mi Hee Lim

Proc. Natl. Acad. Sci. U.S.A., 2020, 117, 5160
DOI: 10.1073/pnas.1916944117

A Systematic Screening of Traditional Chinese Medicine Identifies Two Novel Inhibitors Against the Cytotoxic Aggregation of Amyloid Beta

Liang Ma, Jiaojiao Zheng, Huijing Chen, Xia Zeng, Shilin Wang, Chen Yang, Xi Li, Yushuo Xiao, Ling Zheng, Hong Chen and Kun Huang

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.637766

Structural Reorganization Mechanism of the Aβ42 Fibril Mediated by N-Substituted Oligopyrrolamide ADH-353

Arushi Dabas and Bhupesh Goyal

ACS Chem. Neurosci., 2024, 15, 3136
DOI: 10.1021/acschemneuro.4c00253

Zn2+ Binding Increases Parallel Structure in the Aβ(16–22) Oligomer by Disrupting Salt Bridge in Antiparallel Structure

Yongshun Song, Mengjiao Wu, Changying Wang, Haiping Fang and Xiaoling Lei

J. Phys. Chem. B, 2024, 128, 1385
DOI: 10.1021/acs.jpcb.3c06925

The Synergistic Potential of Rationally Designed Phenol-Triazole Derivatives to Attenuate Aβ/Cu2+–Aβ Aggregation and Reactive Oxygen Species

Gagandeep Kaur, Opinder Kaur Mankoo, Amandeep Kaur, Sukhmani Mann, Nitesh Priyadarshi, Prit Pal Singh, Bhupesh Goyal, Nitin Kumar Singhal and Deepti Goyal

ACS Chem. Neurosci., 2025, 16, 3020
DOI: 10.1021/acschemneuro.5c00386

Alzheimer’s Disease: From Molecular Mechanisms to Promising Therapeutic Strategies

Anna V. Ivanova, Alexandra D. Kutuzova, Ilia A. Kuzmichev and Maxim A. Abakumov

IJMS, 2025, 26, 9444
DOI: 10.3390/ijms26199444

Investigating the combined effect of copper, zinc, and iron ions on truncated and full-length Aβ peptides: insights from molecular dynamics simulation

Mona Sohrabi, Mohammad Reza Bozorgmehr and Mohammad Momen-Heravi

Journal of Biomolecular Structure and Dynamics, 2025, 43, 4165
DOI: 10.1080/07391102.2024.2301755

Studies on the cross‐interaction between hIAPP and Aβ25–35 and the aggregation process in binary mixture by electrospray ionization‐ion mobility‐mass spectrometry

Bo Pang, Xiaoyu Zhuang, Xinyu Bian, Shu Liu, Zhiqiang Liu and Fengrui Song

J Mass Spectrom, 2020, 55
DOI: 10.1002/jms.4643

Pterostilbene Alleviates Aβ1‐42‐Induced Cognitive Dysfunction via Inhibition of Oxidative Stress by Activating Nrf2 Signaling Pathway

Jikai Xu, Jingyu Liu, Qing Li, Yan Mi, Di Zhou, Qingqi Meng, Gang Chen, Ning Li and Yue Hou

Molecular Nutrition Food Res, 2021, 65
DOI: 10.1002/mnfr.202000711

Experimental and translational models of Alzheimer’s disease: From neurodegeneration to novel therapeutic insights

Nadeemullah Khan, Somnath De, Suhasini Boddu and Navya Pravala

The Journal of Prevention of Alzheimer's Disease, 2026, 13, 100498
DOI: 10.1016/j.tjpad.2026.100498

Fluorescent Sensing Platforms for Detecting and Imaging the Biomarkers of Alzheimer’s Disease

Xingyun Liu, Yibiao Liu and Qiong Liu

Biosensors, 2023, 13, 515
DOI: 10.3390/bios13050515

Cerebrospinal fluid: A specific biofluid for the biosensing of Alzheimer's diseases biomarkers

Arezoo Mirzaie, Hassan Nasrollahpour, Balal Khalilzadeh, Ali Akbar Jamali, Raymond J. Spiteri, Hadi Yousefi, Ibrahim Isildak and Reza Rahbarghazi

TrAC Trends in Analytical Chemistry, 2023, 166, 117174
DOI: 10.1016/j.trac.2023.117174

Design, synthesis, and evaluation of 2,2’-bipyridyl derivatives as bifunctional agents against Alzheimer’s disease

Ren-Xian Tan, Wei-Hao Li, Jia-Min Pang, Si-Min Zhong, Xin-Yi Huang, Jun-Ze Deng, Lu-Yi Zhou, Jia-Qiang Wu and Xiao-Qin Wang

Mol Divers, 2024, 28, 1225
DOI: 10.1007/s11030-023-10651-5

Sulforaphene, a CDK5 Inhibitor, attenuates cognitive deficits in a transgenic mouse model of Alzheimer’s disease via reducing Aβ Deposition, tau hyperphosphorylation and synaptic dysfunction

Wen Yang, Qing-Qing Xu, Qiuju Yuan, Yan-Fang Xian and Zhi-Xiu Lin

International Immunopharmacology, 2023, 114, 109504
DOI: 10.1016/j.intimp.2022.109504

Oligoethyleneoxy-Modified 99mTc-Labeled β-Amyloid Imaging Probes with Improved Brain Pharmacokinetics for Single-Photon Emission Computed Tomography

Xiaoyang Zhang, Yaqin Hou, Cheng Peng, Chu Wang, Xiang Wang, Zhigang Liang, Jing Lu, Baian Chen, Jiapei Dai, Boli Liu and Mengchao Cui

J. Med. Chem., 2018, 61, 1330
DOI: 10.1021/acs.jmedchem.7b01834

Determination of amino acids that favour the αL region using Ramachandran propensity plots. Implications for α-sheet as the possible amyloid intermediate

Steven Hayward and E. James Milner-White

Journal of Structural Biology, 2021, 213, 107738
DOI: 10.1016/j.jsb.2021.107738

Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in Caenorhabditis elegans

Zong-Ping Zhang, Xue Bai, Wen-Bo Cui, Xiao-Han Chen, Xu Liu, De-Juan Zhi, Zhan-Xin Zhang, Dong-Qing Fei and Dong-Sheng Wang

IJMS, 2022, 23, 6871
DOI: 10.3390/ijms23126871

Unveiling the biological interface of protein complexes by mass spectrometry‐coupled methods

Goeun Shin and Sung In Lim

Proteins, 2023, 91, 593
DOI: 10.1002/prot.26459

Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms

Guowang Cheng, Aihua Xie, Zhao Yan, Xiaozhen Zhu, Yafang Song and Tongkai Chen

Brain-X, 2023, 1
DOI: 10.1002/brx2.27

Zinc sequestering dual-functional molecules for bimodal targeting inhibition of Aβ42-aggregation

Shoucai Yan, Peng Liu, Yu Si, Hao Wu, Jiayu Quan, Lei Wang and Engin U. Akkaya

Bioorganic Chemistry, 2026, 173, 109629
DOI: 10.1016/j.bioorg.2026.109629

A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42

Tomer Illouz, Ravit Madar, Kathleen Griffioen and Eitan Okun

Journal of Neuroscience Methods, 2017, 291, 28
DOI: 10.1016/j.jneumeth.2017.07.022

Up-regulation of GPR139 in the medial septum ameliorates cognitive impairment in two mouse models of Alzheimer’s disease

Ronghao Mu, Xiaoying Hou, Qi Liu, Wan Wang, Chi Qin and Huixian Li

International Immunopharmacology, 2024, 130, 111786
DOI: 10.1016/j.intimp.2024.111786

Contribution of hyperglycemia-induced changes in microglia to Alzheimer’s disease pathology

Maricarmen Hernández-Rodríguez, Cecilia Flores Clemente, Martha Edith Macías-Pérez, Rolando Alberto Rodríguez-Fonseca, M. Inés Nicolás Vázquez, Joel Martínez, Rene Miranda Ruvalcaba, Martín Martínez Rosas and Elvia Mera Jiménez

Pharmacol. Rep, 2022, 74, 832
DOI: 10.1007/s43440-022-00405-9

Changes of the Primary Cilia in Alzheimer's Disease Pathogenesis

Angyang Guo, Han Wang, Yan Zhang and Hongbin Huang

Eur J of Neuroscience, 2025, 61
DOI: 10.1111/ejn.70125

Interaction of gallium, indium, and vanadyl curcumin complexes with hen egg-white lysozyme (HEWL): Mechanistic aspects and evaluation of antiamyloidogenic activity

Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi and Leila Hassani

Biochemical and Biophysical Research Communications, 2024, 691, 149307
DOI: 10.1016/j.bbrc.2023.149307

Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3

Kelly Z. Young, Naw May P. Cartee, Magdalena I. Ivanova and Michael M. Wang

Experimental Neurology, 2020, 328, 113261
DOI: 10.1016/j.expneurol.2020.113261

Label-Free Infrared Spectroscopic Imaging Reveals Heterogeneity of β-Sheet Aggregates in Alzheimer’s Disease

Matthew P. Confer, Brooke M. Holcombe, Abigail G. Foes, John M. Holmquist, Savannah C. Walker, Sanghamitra Deb and Ayanjeet Ghosh

J. Phys. Chem. Lett., 2021, 12, 9662
DOI: 10.1021/acs.jpclett.1c02306

Rational design of photoactivatable metal complexes to target and modulate amyloid-β peptides

Jimin Kwak, Junhyeok Woo, Seongmin Park and Mi Hee Lim

Journal of Inorganic Biochemistry, 2023, 238, 112053
DOI: 10.1016/j.jinorgbio.2022.112053

Synaptic and synchronic impairments in subcortical brain regions associated with early non-cognitive dysfunction in Alzheimer’s disease

Nicolás Riffo-Lepe, Juliana González-Sanmiguel, Lorena Armijo-Weingart, Paulina Saavedra-Sieyes, David Hernandez, Gerson Ramos, Loreto S. San Martín and Luis G. Aguayo

Neural Regeneration Research, 2026, 21, 248
DOI: 10.4103/NRR.NRR-D-24-01052

Sulfobutylether-β-Cyclodextrin for Inhibition and Rupture of Amyloid Fibrils

Meenakshi N. Shinde, Raman Khurana, Nilotpal Barooah, Achikanath C. Bhasikuttan and Jyotirmayee Mohanty

J. Phys. Chem. C, 2017, 121, 20057
DOI: 10.1021/acs.jpcc.7b07286

Lipid membranes induce structural conversion from amyloid oligomers to fibrils

Lei Gu and Zhefeng Guo

Biochemical and Biophysical Research Communications, 2021, 557, 122
DOI: 10.1016/j.bbrc.2021.03.174

Limonin Isolated From Pomelo Seed Antagonizes Aβ25-35-Mediated Neuron Injury via PI3K/AKT Signaling Pathway by Regulating Cell Apoptosis

Yuanxin Qiu, Jingxian Yang, Lukai Ma, Mingyue Song and Guo Liu

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.879028

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation

Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim and YoungSoo Kim

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-36167-4

Versatile nanomaterials for Alzheimer's disease: Pathogenesis inspired disease-modifying therapy

Yilong Xi, Yun Chen, Yi Jin, Guochen Han, Mingjie Song, Tingting Song, Yang Shi, Ling Tao, Zewei Huang, Jianping Zhou, Yang Ding and Huaqing Zhang

Journal of Controlled Release, 2022, 345, 38
DOI: 10.1016/j.jconrel.2022.02.034

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

Ofek Oren, Victor Banerjee, Ran Taube and Niv Papo

Biochemical Journal, 2018, 475, 3087
DOI: 10.1042/BCJ20180247

A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer’s disease (AD)

Pinky Gehlot, Rekha Pathak, Sunil Kumar, Naveen Kumar Choudhary and Vivek Kumar Vyas

Bioorganic & Medicinal Chemistry, 2024, 113, 117925
DOI: 10.1016/j.bmc.2024.117925

Rational Design of a Cocktail of Inhibitors against Aβ Aggregation

Gao Li, Wu‐Yue Yang, Wen‐Hao Li, Yun‐Yi Luo, Yeh‐Jun Lim, Yang Li, Ashim Paul, Daniel Segal, Liu Hong and Yan‐Mei Li

Chemistry A European J, 2020, 26, 3499
DOI: 10.1002/chem.201905621

Multifaceted Influences of Melanin‐Like Particles on Amyloid‐beta Aggregation

Haeun Song, Yoonyoung Kim, Inkyu Kim, Young‐Kwan Kim, Sunbum Kwon and Kyungtae Kang

Chemistry An Asian Journal, 2020, 15, 91
DOI: 10.1002/asia.201901405

Trehalose-Conjugated, Catechin-Loaded Polylactide Nanoparticles for Improved Neuroprotection against Intracellular Polyglutamine Aggregates

Suman Mandal, Koushik Debnath, Nihar R. Jana and Nikhil R. Jana

Biomacromolecules, 2020, 21, 1578
DOI: 10.1021/acs.biomac.0c00143

Isotopic Dilution Provides No Evidence for Cu2+-Bridged β-Amyloid Homo-Oligomers

Simon C. Drew

Appl Magn Reson, 2025, 56, 1423
DOI: 10.1007/s00723-025-01795-8

Rapid size-exclusion high performance liquid chromatography method for the quality control of amyloid-β oligomers

Igor Camargo Fontana, Pâmela Cristina Lukasewicz Ferreira, Diogo Miron, Luis Eduardo Santos, Sergio T. Ferreira, Diogo Onofre Souza, Grace Gosmann, Eduardo R. Zimmer and Aline Rigon Zimmer

Journal of Chromatography A, 2021, 1643, 462024
DOI: 10.1016/j.chroma.2021.462024

Aβ42 and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer’s disease

Liding Zhang, Kai Cao, Jun Xie, Xiaohan Liang, Hui Gong, Qingming Luo and Haiming Luo

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02543-z

Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers

Angelo Moscoso Jamerlan, Kyu Hwan Shim, Niti Sharma and Seong Soo A. An

IJMS, 2025, 26, 1199
DOI: 10.3390/ijms26031199

NMR-driven identification of anti-amyloidogenic compounds in green and roasted coffee extracts

Carlotta Ciaramelli, Alessandro Palmioli, Ada De Luigi, Laura Colombo, Gessica Sala, Chiara Riva, Chiara Paola Zoia, Mario Salmona and Cristina Airoldi

Food Chemistry, 2018, 252, 171
DOI: 10.1016/j.foodchem.2018.01.075

Cell models for Alzheimer’s and Parkinson’s disease: At the interface of biology and drug discovery

Sandra Cetin, Damijan Knez, Stanislav Gobec, Janko Kos and Anja Pišlar

Biomedicine & Pharmacotherapy, 2022, 149, 112924
DOI: 10.1016/j.biopha.2022.112924

Chemical Strategies to Modulate Amyloidogenesis Associated with Neurodegenerative Diseases

Chanju Na, Youngeun Jang, Mikyung Son and Mi Hee Lim

ACS Appl. Mater. Interfaces, 2026, 18, 9285
DOI: 10.1021/acsami.5c20362

Mercury Ion Binding to Apolipoprotein E Variants ApoE2, ApoE3, and ApoE4: Similar Binding Affinities but Different Structure Induction Effects

Elina Berntsson, Merlin Sardis, Andra Noormägi, Jüri Jarvet, Per M. Roos, Vello Tõugu, Astrid Gräslund, Peep Palumaa and Sebastian K. T. S. Wärmländer

ACS Omega, 2022, 7, 28924
DOI: 10.1021/acsomega.2c02254

Exploring the Connection Between Nanomaterials and Neurodegenerative Disorders

Sitansu Sekhar Nanda and Dong Kee Yi

Micromachines, 2024, 15, 1382
DOI: 10.3390/mi15111382

Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies

Jifa Zhang, Yinglu Zhang, Jiaxing Wang, Yilin Xia, Jiaxian Zhang and Lei Chen

Sig Transduct Target Ther, 2024, 9
DOI: 10.1038/s41392-024-01911-3

Quercetin-derived red emission carbon dots: A multifunctional theranostic nano-agent against Alzheimer’s β-amyloid fibrillogenesis

Zitong Wei, Xiaoyan Dong and Yan Sun

Colloids and Surfaces B: Biointerfaces, 2024, 238, 113907
DOI: 10.1016/j.colsurfb.2024.113907

Amyloid‐β in Alzheimer's disease: Structure, toxicity, distribution, treatment, and prospects

Yifan Yu, Shilong Yu, Giuseppe Battaglia and Xiaohe Tian

Ibrain, 2024
DOI: 10.1002/ibra.12155

Impact of nanoplastics on Alzheimer ’s disease: Enhanced amyloid-β peptide aggregation and augmented neurotoxicity

Xiaoli Gou, Yongchun Fu, Juan Li, Juan Xiang, Minghui Yang and Yi Zhang

Journal of Hazardous Materials, 2024, 465, 133518
DOI: 10.1016/j.jhazmat.2024.133518

A Novel Drosophila Model of Alzheimer’s Disease to Study Aβ Proteotoxicity in the Digestive Tract

Greta Elovsson, Therése Klingstedt, Mikaela Brown, K. Peter R. Nilsson and Ann-Christin Brorsson

IJMS, 2024, 25, 2105
DOI: 10.3390/ijms25042105

Designed Polymer Micelle for Clearing Amyloid Protein Aggregates via Up-Regulated Autophagy

Koushik Debnath, Nihar R. Jana and Nikhil R. Jana

ACS Biomater. Sci. Eng., 2019, 5, 390
DOI: 10.1021/acsbiomaterials.8b01196

Nanomicelles of taurine inhibit the fibrillation and toxicity of amyloid β1-42 peptide

Natália Cristina Gomes-da-Silva, Marilia Amável Gomes Soares, Eduardo Ricci-Junior, Maria do Socorro do Nascimento Amorim, Luciana Magalhães Rebelo Alencar, Prapanna Bhattarai, Lin Zhu, Cristian Follmer and Ralph Santos-Oliveira

Journal of Drug Delivery Science and Technology, 2023, 86, 104721
DOI: 10.1016/j.jddst.2023.104721

Modulation of Amyloid β-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues

Ersilia De Lorenzi, Davide Franceschini, Cecilia Contardi, Rita Maria Concetta Di Martino, Francesca Seghetti, Massimo Serra, Federica Bisceglia, Andrea Pagetta, Morena Zusso and Federica Belluti

IJMS, 2022, 23, 4381
DOI: 10.3390/ijms23084381

The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance

Huahua Song, Xinyi Ma, Jianrong Xu, Qingxiang Song, Meng Hu, Xiao Gu, Qian Zhang, Lina Hou, Lepei Chen, Yukun Huang, Ping Yu, Dayuan Wang, Gan Jiang, Meng Huang, Jun Chen, Hongzhuan Chen and Xiaoling Gao

Nano Res., 2018, 11, 5615
DOI: 10.1007/s12274-018-2107-8

O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation

Dangliang Liu, Qijia Wei, Wencheng Xia, Changdong He, Qikai Zhang, Lu Huang, Xiaoya Wang, Yunpeng Sun, Yeyang Ma, Xiaohui Zhang, Yuan Wang, Xiaomeng Shi, Cong Liu and Suwei Dong

J. Am. Chem. Soc., 2021, 143, 20216
DOI: 10.1021/jacs.1c08607

Patchouli alcohol ameliorates the learning and memory impairments in an animal model of Alzheimer's disease via modulating SIRT1

Qing-Qing Xu, Zi-Ren Su, Zhen Hu, Wen Yang, Yan-Fang Xian and Zhi-Xiu Lin

Phytomedicine, 2022, 106, 154441
DOI: 10.1016/j.phymed.2022.154441

A near-infrared fluorescent probe for amyloid-β aggregates

Misun Lee, Mingeun Kim, Anjong Florence Tikum, Hyuck Jin Lee, Vijayan Thamilarasan, Mi Hee Lim and Jinheung Kim

Dyes and Pigments, 2019, 162, 97
DOI: 10.1016/j.dyepig.2018.10.013

Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β‐amyloid‐toxicity

Y. Wang, Q. Wu, B. G. Anand, G. Karthivashan, G. Phukan, J. Yang, G. Thinakaran, D. Westaway and S. Kar

Neuropathology Appl Neurobio, 2020, 46, 686
DOI: 10.1111/nan.12647

Vitamin E modified polyamidoamine dendrimer for piperine delivery to alleviate Aβ 1–42 induced neurotoxicity in Balb/c mice model

Ajit Singh, Debarati Rakshit, Ankit Kumar, Awanish Mishra and Rahul Shukla

Journal of Biomaterials Science, Polymer Edition, 2023, 34, 2232
DOI: 10.1080/09205063.2023.2230857

The Different Faces of the TDP-43 Low-Complexity Domain: The Formation of Liquid Droplets and Amyloid Fibrils

Hung-Ming Chien, Chi-Chang Lee and Joseph Jen-Tse Huang

IJMS, 2021, 22, 8213
DOI: 10.3390/ijms22158213

Advanced analytical methodologies in Alzheimer’s disease drug discovery

Angela De Simone, Marina Naldi, Daniele Tedesco, Manuela Bartolini, Lara Davani and Vincenza Andrisano

Journal of Pharmaceutical and Biomedical Analysis, 2020, 178, 112899
DOI: 10.1016/j.jpba.2019.112899

A Dual-Pronged Approach: A Ruthenium(III) Complex That Modulates Amyloid-β Aggregation and Disrupts Its Formed Aggregates

Gideon K. Yawson, Mark F. Will, Samantha E. Huffman, Evan T. Strandquist, Paige J. Bothwell, Ethan B. Oliver, C. Fiore Apuzzo, David C. Platt, Christopher S. Weitzel, Marjorie A. Jones, Gregory M. Ferrence, Christopher G. Hamaker and Michael I. Webb

Inorg. Chem., 2022, 61, 2733
DOI: 10.1021/acs.inorgchem.1c01651

Animal models of Alzheimer’s disease: preclinical insights and challenges

Qing-Qing Xu, Wen Yang, Mei Zhong, Zhi-Xiu Lin, Nora E Gray and Yan-Fang Xian

Acta Materia Medica, 2023, 2
DOI: 10.15212/AMM-2023-0001

Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Marianna Kulka and Satyabrata Kar

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01269-0

New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery

Haishu Chen, Jinan Xu, Hanyuan Xu, Tiancheng Luo, Yihao Li, Ke Jiang, Yangping Shentu and Zhiqian Tong

Pharmaceutics, 2023, 15, 1133
DOI: 10.3390/pharmaceutics15041133

Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models

Wen-Bo Cui, Zong-Ping Zhang, Xue Bai, Shan-Shan Wang, Xiao-Han Chen, Xu Liu, Pan-Jie Su, De-Juan Zhi, Dong-Qing Fei, Zhan-Xin Zhang and Dong-Sheng Wang

IJMS, 2022, 23, 10030
DOI: 10.3390/ijms231710030

Evidence from ITIR-FCS Diffusion Studies that the Amyloid-Beta (Aβ) Peptide Does Not Perturb Plasma Membrane Fluidity in Neuronal Cells

Justin Ng, Roger D. Kamm, Thorsten Wohland and Rachel S. Kraut

Journal of Molecular Biology, 2018, 430, 3439
DOI: 10.1016/j.jmb.2018.04.030

Solvent Relaxation NMR: A Tool for Real-Time Monitoring Water Dynamics in Protein Aggregation Landscape

Ipsita Chakraborty, Rajiv K. Kar, Dibakar Sarkar, Sourav Kumar, Nakul C. Maiti, Atin Kumar Mandal and Anirban Bhunia

ACS Chem. Neurosci., 2021, 12, 2903
DOI: 10.1021/acschemneuro.1c00262

Total synthesis, stereochemical assignment, and biological evaluation of L-755,807

Kosaku Tanaka, Yusuke Honma, Chihiro Yamaguchi, Lina Aoki, Minami Saito, Momoko Suzuki, Kazuhiro Arahata, Kaoru Kinoshita, Kiyotaka Koyama, Kenichi Kobayashi and Hiroshi Kogen

Tetrahedron, 2019, 75, 1085
DOI: 10.1016/j.tet.2019.01.020

Prussian blue nanocages as efficient radical scavengers and photothermal agents for reducing amyloid-beta induced neurotoxicity

Ting Wu, Xining Zhang, Shuangfei Cai, Wei Zhang and Rong Yang

Colloids and Surfaces B: Biointerfaces, 2025, 246, 114369
DOI: 10.1016/j.colsurfb.2024.114369

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Phuong H. Nguyen, Ayyalusamy Ramamoorthy, Bikash R. Sahoo, Jie Zheng, Peter Faller, John E. Straub, Laura Dominguez, Joan-Emma Shea, Nikolay V. Dokholyan, Alfonso De Simone, Buyong Ma, Ruth Nussinov, Saeed Najafi, Son Tung Ngo, Antoine Loquet, Mara Chiricotto, Pritam Ganguly, James McCarty, Mai Suan Li, Carol Hall, Yiming Wang, Yifat Miller, Simone Melchionna, Birgit Habenstein, Stepan Timr, Jiaxing Chen, Brianna Hnath, Birgit Strodel, Rakez Kayed, Sylvain Lesné, Guanghong Wei, Fabio Sterpone, Andrew J. Doig and Philippe Derreumaux

Chem. Rev., 2021, 121, 2545
DOI: 10.1021/acs.chemrev.0c01122

Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for Soluble and Insoluble Amyloid β Aggregates in Alzheimer’s Disease

Liang Sun, Hong-Jun Cho, Soumyo Sen, Andres S. Arango, Truc T. Huynh, Yiran Huang, Nilantha Bandara, Buck E. Rogers, Emad Tajkhorshid and Liviu M. Mirica

J. Am. Chem. Soc., 2021, 143, 10462
DOI: 10.1021/jacs.1c05470

Technological advances in electrochemical biosensors for the detection of disease biomarkers

Jae Hyun Kim, Young Joon Suh, Dongsung Park, Hyoju Yim, Hongrae Kim, Hye Jin Kim, Dae Sung Yoon and Kyo Seon Hwang

Biomed. Eng. Lett., 2021, 11, 309
DOI: 10.1007/s13534-021-00204-w

Emerging biophysical origins and pathogenic implications of amyloid oligomers

Huayuan Tang, Nicholas Andrikopoulos, Yuhuan Li, Stone Ke, Yunxiang Sun, Feng Ding and Pu Chun Ke

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-58335-y

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Zonghua Li, Francis Shue, Na Zhao, Mitsuru Shinohara and Guojun Bu

Mol Neurodegeneration, 2020, 15
DOI: 10.1186/s13024-020-00413-4

Emerging two-dimensional materials-based diagnosis of neurodegenerative diseases: Status and challenges

Jingwen Wu, Wentao Dong, Zhongsheng Zhang, Jia Liu, Miriam Akioma, Jun Liu, Yibiao Liu, Artem Pliss, Xueji Zhang and Ping Luan

Nano Today, 2021, 40, 101284
DOI: 10.1016/j.nantod.2021.101284

Cascade primer exchange reaction-based amplification strategy for sensitive and portable detection of amyloid β oligomer using personal glucose meters

Yayun An, Dafeng Jiang, Nan Zhang and Wei Jiang

Analytica Chimica Acta, 2022, 1232, 340440
DOI: 10.1016/j.aca.2022.340440

Chlorin e6 and Amyloid-Targeting Peptide-Conjugated Superparamagnetic Iron Oxide Nanoparticles for Synchronous Amyloid Dual-Modal Imaging and Clearance in Alzheimer’s Therapy

Chaoren Yan, Yuming Qi, Ruobing Zhao, Zhaohong Zhu, Zhaoxiong Yan, Qian Chen, Yixuan Wang, Yansong Li, Lianfeng Liu, Nan Zhang, Huijuan Lian, Chaoli Wang and Jingming Shi

ACS Appl. Nano Mater., 2025, 8, 22218
DOI: 10.1021/acsanm.5c03854

Creating an Amyloid ‘Kaleidoscope’ Using Short Iodinated Peptides

Danni Li, Yeyang Ma, Wencheng Xia, Youqi Tao, Yiling Zhang, Hong Zhang, Dan Li, Bin Dai and Cong Liu

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202310737

Emerging Brain‐Pathophysiology‐Mimetic Platforms for Studying Neurodegenerative Diseases: Brain Organoids and Brains‐on‐a‐Chip

Seokyoung Bang, Songhyun Lee, Nakwon Choi and Hong Nam Kim

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202002119

Synthesis, single crystal characterization and anti-AD activities of a novel complex of Cu(II) with in situ formed protonated chrysin derivative ligand

Chang Liu, Jianhua Wu, Chengting Hu, Aihong Yang, Rui Shen and Xiaodi Kou

Journal of Inorganic Biochemistry, 2023, 239, 112086
DOI: 10.1016/j.jinorgbio.2022.112086

Structure‐Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid‐β Aggregation

Mantas Žvirblis, Andrius Sakalauskas, Saeid Hadi Ali Janvand, Virginija Dudutienė, Mantas Žiaunys, Rūta Sniečkutė, Daniel E. Otzen, Vytautas Smirnovas and Daumantas Matulis

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402330

Modulating Amyloid-β Toxicity: In Vitro Analysis of Aβ42(G37V) Variant Impact on Aβ42 Aggregation and Cytotoxicity

Shu-Hsiang Huang, Shang-Ting Fang, Chin-Hao Yang, Je-Wen Liou and Yi-Cheng Chen

IJMS, 2024, 25, 13219
DOI: 10.3390/ijms252313219

A novel peptide derived from vascular endothelial growth factor prevents amyloid beta aggregation and toxicity

P. Bouvet, P. de Gea, M. Aimard, N. Chounlamountri, J. Honnorat, J. G. Delcros, P. A. Salin and C. Meissirel

Aging Cell, 2023, 22
DOI: 10.1111/acel.13907

Benzylpiperidine-pyridazin-3(2H)-one derivatives as potential multifunctional agents against Alzheimer's disease

Yichun Shi, Heng Zhang, Shiqin Cong, Xingyu Zhu, Yao Liu, Jinjin Li, Ke Tang, Rong Xue, Xiuxiu Liu, Zhenghuai Tan, Junli Chen and Yong Deng

European Journal of Medicinal Chemistry, 2026, 303, 118437
DOI: 10.1016/j.ejmech.2025.118437

Impact of tyrosine amination on the aggregation and neurotoxicity of amyloid-β

Ting Hu, Jinming Wu, Shitao Fu, Hailing Li and Zhonghong Gao

International Journal of Biological Macromolecules, 2025, 306, 141700
DOI: 10.1016/j.ijbiomac.2025.141700

Rational Design of a Cu Chelator That Mitigates Cu‐Induced ROS Production by Amyloid Beta

Suchitra Mitra, Kallol Talukdar, Pallavi Prasad, Sandeep K. Misra, Shabana Khan, Joshua S. Sharp, Jonah W. Jurss and Saumen Chakraborty

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100485

Characterization of ene reaction products of Cookson-type fluorescent reagents and their application for recognizing amyloid β aggregation

Kotone Nojiri, Yusuke Hatakawa, Seon Hwa Lee and Tomoyuki Oe

ANAL. SCI., 2025, 41, 1343
DOI: 10.1007/s44211-025-00795-9

Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer’s Disease and Neuronal Cell Death

Ravit Malishev, Sukhendu Nandi, Dariusz Śmiłowicz, Shamchal Bakavayev, Stanislav Engel, Nir Bujanover, Roi Gazit, Nils Metzler-Nolte and Raz Jelinek

ACS Chem. Neurosci., 2019, 10, 3555
DOI: 10.1021/acschemneuro.9b00177

Atomic-thick porous Pd nanosheets with antioxidant enzyme-like activities and photothermal properties for potential Alzheimer’s disease treatment

Jianwei Ding, Wendi Luo, Ting Wu, Shuangfei Cai, ZiAn Pan, Haolin Li, Bin Tu, Qiaojun Fang, Xiyun Yan and Rong Yang

Nano Today, 2024, 54, 102121
DOI: 10.1016/j.nantod.2023.102121

Azo-Stilbene and Pyridine–Amine Hybrid Multifunctional Molecules to Target Metal-Mediated Neurotoxicity and Amyloid-β Aggregation in Alzheimer’s Disease

Monika Rana, Hong-Jun Cho, Hemant Arya, Tarun Kumar Bhatt, Kishalay Bhar, Surabhi Bhatt, Liviu M. Mirica and Anuj Kumar Sharma

Inorg. Chem., 2022, 61, 10294
DOI: 10.1021/acs.inorgchem.2c00502

S‐9‐PAHSA Attenuates Aβ Accumulation and Improves Cognitive Deficits by Promoting Mitochondrial Autophagy in 5xFAD Mice

Chenyu Lu, Jiaoqi Ren, Shanshan Huang, Meng Wang, Houguang Zhou and Jingchun Guo

Eur J of Neuroscience, 2025, 61
DOI: 10.1111/ejn.70118

Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research

Haijun Yang, Fantian Zeng, Yunchun Luo, Chao Zheng, Chongzhao Ran and Jian Yang

Molecules, 2022, 27, 3879
DOI: 10.3390/molecules27123879

Adsorption, Aggregation, and Diffusion Behavior of Amyloid β on the Lipid Membrane

Akane Iida-Adachi and Hideki Nabika

e-J. Surf. Sci. Nanotechnol., 2023, 21, 169
DOI: 10.1380/ejssnt.2023-019

Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer’s Disease: Metal–Amyloid-β

Geewoo Nam and Mi Hee Lim

Chem. Lett., 2019, 48, 951
DOI: 10.1246/cl.190281

Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers

Bikash Ranjan Sahoo, Michael E. Bekier, Zichen Liu, Vojc Kocman, Andrea K. Stoddard, G.M. Anantharamaiah, James Nowick, Carol A. Fierke, Yanzhuang Wang and Ayyalusamy Ramamoorthy

Journal of Molecular Biology, 2020, 432, 1020
DOI: 10.1016/j.jmb.2019.12.005

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi and Kambiz Hassanzadeh

CNS Neurosci Ther, 2025, 31
DOI: 10.1002/cns.70688

Amphiphilic Molecules Exhibiting Zwitterionic Excited‐State Intramolecular Proton Transfer and Near‐Infrared Emission for the Detection of Amyloid β Aggregates in Alzheimer's Disease**

Zhengxin Yu, Yusuff Moshood, Marcin K. Wozniak, Shrey Patel, Karna Terpstra, Daniel A. Llano, Lawrence W. Dobrucki and Liviu M. Mirica

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202302408

Comparison of the reaction of methylglyoxal (MGO) with murine and human amyloid beta (Aβ): Insights into a mechanism of Alzheimer’s disease (AD)

Sydney O. Shuster, Sebastian M. Fica-Contreras, Jake S. Hedges, Nathaniel J. Henning and Sunhee Choi

Biochemical and Biophysical Research Communications, 2020, 533, 1298
DOI: 10.1016/j.bbrc.2020.10.008

Artificial Chiral Interfaces against Amyloid-β Peptide Aggregation: Research Progress and Challenges

Zhe Zhou, You-Quan Gu and Hang-Xing Wang

ACS Chem. Neurosci., 2021, 12, 4236
DOI: 10.1021/acschemneuro.1c00544

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity

Bibin G. Anand, Qi Wu, Govindarajan Karthivashan, Kiran P. Shejale, Sara Amidian, Holger Wille and Satyabrata Kar

Bioactive Materials, 2021, 6, 4491
DOI: 10.1016/j.bioactmat.2021.04.029

PET molecular imaging for pathophysiological visualization in Alzheimer’s disease

Jing Wang, Chentao Jin, Jinyun Zhou, Rui Zhou, Mei Tian, Hyeon Jeong Lee and Hong Zhang

Eur J Nucl Med Mol Imaging, 2023, 50, 765
DOI: 10.1007/s00259-022-05999-z

Aptamer-Induced-Dimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrPC Signaling

Shuya Liu, Shiwei Li, Jirong Lin, Jingying Li and Huanghao Yang

J. Am. Chem. Soc., 2022, 144, 9264
DOI: 10.1021/jacs.2c00287

KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion

Xiaolei Han, Chaoqun Wang, Lin Song, Xiaojie Wang, Shi Tang, Tingting Hou, Cuicui Liu, Xiaoyan Liang, Chengxuan Qiu, Yongxiang Wang and Yifeng Du

eBioMedicine, 2022, 78, 103980
DOI: 10.1016/j.ebiom.2022.103980

Formulation development of tocopherol polyethylene glycol nanoengineered polyamidoamine dendrimer for neuroprotection and treatment of Alzheimer disease

Ajit Singh, Rewati R. Ujjwal, Saba Naqvi, Rahul K. Verma, Sanjay Tiwari, Prashant Kesharwani and Rahul Shukla

Journal of Drug Targeting, 2022, 30, 777
DOI: 10.1080/1061186X.2022.2063297

Linking Cerebrovascular Dysfunction to Age-Related Hearing Loss and Alzheimer’s Disease—Are Systemic Approaches for Diagnosis and Therapy Required?

Carola Y. Förster, Sergey Shityakov, Verena Scheper and Thomas Lenarz

Biomolecules, 2022, 12, 1717
DOI: 10.3390/biom12111717

Oxidative Damages on the Alzheimer’s Related-Aβ Peptide Alters Its Ability to Assemble

Clémence Cheignon, Fabrice Collin, Laurent Sabater and Christelle Hureau

Antioxidants, 2023, 12, 472
DOI: 10.3390/antiox12020472

Copper Imbalance in Alzheimer’s Disease and Its Link with the Amyloid Hypothesis: Towards a Combined Clinical, Chemical, and Genetic Etiology

Rosanna Squitti, Peter Faller, Christelle Hureau, Alberto Granzotto, Anthony R. White and Kasper P. Kepp

JAD, 2021, 83, 23
DOI: 10.3233/JAD-201556

Toward the Mode of Action of the Clinical Stage All-d-Enantiomeric Peptide RD2 on Aβ42 Aggregation

Tao Zhang, Ian Gering, Janine Kutzsche, Luitgard Nagel-Steger and Dieter Willbold

ACS Chem. Neurosci., 2019, 10, 4800
DOI: 10.1021/acschemneuro.9b00458

A simple approach to quantitative determination of soluble amyloid-β peptides using a ratiometric fluorescence probe

Changhong Li, Liu Yang, Yuwang Han and Xiaohui Wang

Biosensors and Bioelectronics, 2019, 142, 111518
DOI: 10.1016/j.bios.2019.111518

Toward a Rational Design to Regulate β-Amyloid Fibrillation for Alzheimer’s Disease Treatment

Xu Han and Gefei He

ACS Chem. Neurosci., 2018, 9, 198
DOI: 10.1021/acschemneuro.7b00477

Natural products targeting amyloid-β oligomer neurotoxicity in Alzheimer's disease

Priscila Baltazar Gonçalves, Ana Carolina Rennó Sodero and Yraima Cordeiro

European Journal of Medicinal Chemistry, 2024, 276, 116684
DOI: 10.1016/j.ejmech.2024.116684

Multifunctional Gold Nanoparticle-Conjugated Cellulose Nanoonions Alleviate Aβ42 Fibrillation-Induced Toxicity via Regulation of Oxidative Stress and Ion Homeostasis

Syed M. S. Abidi, Aqib Iqbal Dar and Amitabha Acharya

Biomacromolecules, 2021, 22, 2419
DOI: 10.1021/acs.biomac.1c00228

Self‐Assembly and Neurotoxicity of β‐Amyloid (21–40) Peptide Fragment: The Regulatory Role of GxxxG Motifs

Dibakar Sarkar, Ipsita Chakraborty, Marcello Condorelli, Baijayanti Ghosh, Thorben Mass, Markus Weingarth, Atin K Mandal, Carmelo La Rosa, Vivekanandan Subramanian and Anirban Bhunia

ChemMedChem, 2020, 15, 293
DOI: 10.1002/cmdc.201900620

Nano-Collision Electrochemistry for Real-Time Monitoring of Amyloid-β Oligomerization and Rapid Screening of Degrading Drugs

Jinrong Liu, Luan Chen, Zhi-Ling Zhang, Wei Wen, Xiuhua Zhang, Zhen Wu and Shengfu Wang

Anal. Chem., 2025, 97, 4898
DOI: 10.1021/acs.analchem.4c04598

Chemical Approaches for Array Based Detection of Amyloids

Paulo M. Simon, Yijia Xu and Amandeep Kaur

Advanced Sensor Research, 2025, 4
DOI: 10.1002/adsr.202500108

High specificity is a key parameter for copper ligands as future therapeutic agents for Alzheimer’s, Wilson’s, and cancer diseases

Anne Robert, Yan Liu, Michel Nguyen, Françoise Benoit-Vical and Bernard Meunier

Comptes Rendus. Chimie, 2025, 28, 755
DOI: 10.5802/crchim.417

Drug-based magnetic imprinted nanoparticles: Enhanced lysozyme amyloid fibrils cleansing and anti-amyloid fibrils toxicity

Chaoren Yan, Nan Zhang, Ping Guan, Peng Chen, Shichao Ding, Tongtong Hou, Xiaoling Hu, Jian Wang and Chaoli Wang

International Journal of Biological Macromolecules, 2020, 153, 723
DOI: 10.1016/j.ijbiomac.2020.03.061

Polyoxometalates: metallodrug agents for combating amyloid aggregation

Mengmeng Ma, Zhenqi Liu, Huisi Zhao, Haochen Zhang, Jinsong Ren and Xiaogang Qu

National Science Review, 2024, 11
DOI: 10.1093/nsr/nwae226

Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal‐Free and Metal‐Associated Amyloid‐β

Seongmin Park, Yelim Yi and Mi Hee Lim

Bulletin Korean Chem Soc, 2021, 42, 17
DOI: 10.1002/bkcs.12172

Chiral effect on Aβ fibrillation from molecular-scale to nanoscale

Guanbin Gao, Guowei Zhu, Liangchong Yu, Zijun Zhang, Ting Zhang, Xinglin Liu, Cheng Zhang, Lin Zhou and Taolei Sun

Nano Res., 2022, 15, 6721
DOI: 10.1007/s12274-022-4303-9

Amyloid-β oligomerization monitored by single-molecule stepwise photobleaching

Lara Dresser, Patrick Hunter, Fatima Yendybayeva, Alex L. Hargreaves, Jamieson A.L. Howard, Gareth J.O. Evans, Mark C. Leake and Steven D. Quinn

Methods, 2021, 193, 80
DOI: 10.1016/j.ymeth.2020.06.007

Rationally designed cyclic peptides and nanomaterials as ‘next-generation’ anti-amyloid therapeutics

Bhushan D. Khairnar, Anjali Jha and Jyutika M. Rajwade

J Mater Sci, 2023, 58, 9834
DOI: 10.1007/s10853-023-08654-6

Development of 11C‐labeled CRANAD‐102 for positron emission tomography imaging of soluble Aβ‐species

Markus Staudt, Vladimir Shalgunov, Maiken Nedergaard and Matthias M. Herth

Labelled Comp Radiopharmac, 2023, 66, 393
DOI: 10.1002/jlcr.4060

Phase 1/2a Intravenous and Subcutaneous Oligomer-Specific Antibody KHK6640 in Mild to Moderate Alzheimer's Disease

Marc Cantillon, N. Andreasen and N. Prins

The Journal of Prevention of Alzheimer's Disease, 2024, 11, 65
DOI: 10.14283/jpad.2024.2

Amyloid protein‐induced sequestration of the eukaryotic ribosome: effect of stoichiometry and polyphenolic inhibitors

Sehnaz Ferdosh, Senjuti Banerjee, Jayshree Singh and Chandana Barat

FEBS Letters, 2022, 596, 1190
DOI: 10.1002/1873-3468.14308

N , N ′-Diacetyl- p -phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice

Min Hee Park, Misun Lee, Geewoo Nam, Mingeun Kim, Juhye Kang, Byung Jo Choi, Min Seock Jeong, Kang Ho Park, Wan Hui Han, Eunyoung Tak, Min Sun Kim, Juri Lee, Yuxi Lin, Young-Ho Lee, Im-Sook Song, Min-Koo Choi, Joo-Yong Lee, Hee Kyung Jin, Jae-sung Bae and Mi Hee Lim

Proc. Natl. Acad. Sci. U.S.A., 2019, 116, 23426
DOI: 10.1073/pnas.1916318116

Molecular Tools to Detect Alloforms of Aβ and Tau: Implications for Multiplexing and Multimodal Diagnosis of Alzheimer’s Disease

Harshit Arora, Madhu Ramesh, Kolla Rajasekhar and Thimmaiah Govindaraju

Bulletin of the Chemical Society of Japan, 2020, 93, 507
DOI: 10.1246/bcsj.20190356

Role of aromatic amino acids in amyloid self-assembly

Ivana M. Stanković, Shuqiang Niu, Michael B. Hall and Snežana D. Zarić

International Journal of Biological Macromolecules, 2020, 156, 949
DOI: 10.1016/j.ijbiomac.2020.03.064

The bioaccessibility of adsorped heavy metals on biofilm-coated microplastics and their implication for the progression of neurodegenerative diseases

Ieshita Pan, Suganiya Umapathy, Praveen Kumar Issac, Md. Mostafizur Rahman, Ajay Guru and Jesu Arockiaraj

Environ Monit Assess, 2023, 195
DOI: 10.1007/s10661-023-11890-7

Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease

Yuanming Li, Jing Zhang, Jiale Wan, Anru Liu and Jinhao Sun

Biomedicine & Pharmacotherapy, 2020, 132, 110887
DOI: 10.1016/j.biopha.2020.110887

Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway

Elise Loppinet, Harrison A. Besser, Christina E. Lee, Wei Zhang, Bianxiao Cui and Chaitan Khosla

J. Am. Chem. Soc., 2023, 145, 18705
DOI: 10.1021/jacs.3c05109

Binding of Hg(I) and Hg(II) Ions to Amyloid‐Beta (Aβ) Peptide Variants Affect their Structure and Aggregation

Elina Berntsson, Andra Noormägi, Kärt Padari, Jüri Jarvet, Astrid Gräslund, Margus Pooga, Peep Palumaa and Sebastian K. T. S. Wärmländer

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500252

Prenylated Curcumin Analogues as Multipotent Tools To Tackle Alzheimer’s Disease

Federica Bisceglia, Francesca Seghetti, Massimo Serra, Morena Zusso, Silvia Gervasoni, Laura Verga, Giulio Vistoli, Cristina Lanni, Michele Catanzaro, Ersilia De Lorenzi and Federica Belluti

ACS Chem. Neurosci., 2019, 10, 1420
DOI: 10.1021/acschemneuro.8b00463

Improvement of electroacupuncture on APP/PS1 transgenic mice in behavioral probably due to reducing deposition of Aβ in hippocampus

Run‐Quan Sun, Zi‐Dong Wang, Jun Zhao, Shuai Wang, Yi‐Zhi Liu, Si‐Yuan Liu, Zhi‐Gang Li and Xin Wang

The Anatomical Record, 2021, 304, 2521
DOI: 10.1002/ar.24737

Boosting the specific molecular recognition of β-amyloid oligomer by constructing of antibody-mimic Y probe

Yan Zheng, Jinge Zhao, Limin Zhang and Weizhi Wang

Sensors and Actuators B: Chemical, 2023, 381, 133418
DOI: 10.1016/j.snb.2023.133418

High-Affinity Fluorescent Probes for the Detection of Soluble and Insoluble Aβ Deposits in Alzheimer’s Disease

Rathnam Mallesh, Juhee Khan, Prabir Kumar Gharai, Subhajit Ghosh, Shubham Garg, Mohammad Umar Arshi and Surajit Ghosh

ACS Chem. Neurosci., 2023
DOI: 10.1021/acschemneuro.2c00787

Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal With Them

Peter Faller and Christelle Hureau

Front. Chem., 2021, 8
DOI: 10.3389/fchem.2020.611227

Effects of Solvent Dimethyl Sulfoxide Invites a Rethink of Its Application in Amyloid Beta Cytotoxicity

Yanhong Fu, Jiafa Zhang, Canhong Yang, Yuanyuan Wang, Yunzhu Yang, Pingming Qiu, Weibing Xie, Shufen Zhang and Tianming Lǚ

Int J Toxicol, 2025, 44, 297
DOI: 10.1177/10915818251338235

Synthesis and Evaluation of New Cyclodextrin Derivatives as Amyloid‐β Aggregation Inhibitors

Valentina Oliveri and Graziella Vecchio

ChemistrySelect, 2019, 4, 10639
DOI: 10.1002/slct.201902402

Amplification of Amyloid Protein-induced Aggregation of the Eukaryotic Ribosome

Sehnaz Ferdosh, Senjuti Banerjee and Chandana Barat

PPL, 2022, 29, 993
DOI: 10.2174/0929866529666220905112156

Amyloid-β-interacting proteins in peripheral fluids of Alzheimer’s disease

Yelim Yi, Jimin Lee and Mi Hee Lim

Trends in Chemistry, 2024, 6, 128
DOI: 10.1016/j.trechm.2024.01.003

Advances and Challenges in Gene Therapy for Alzheimer’s Disease

Fabiana Morroni, Antonella Caccamo, Paula I. Moreira, Jesus Avila, Daniela Galimberti, Miguel A. Pappolla, Germán Plascencia-Villa, Aaron A. Sorensen, Xiongwei Zhu and George Perry

JAD, 2024, 101, S417
DOI: 10.3233/JAD-230783

Photothermal Conjugated Polymers and Their Biological Applications in Imaging and Therapy

Yunxia Wang, Hui Zhang, Zhijun Wang and Liheng Feng

ACS Appl. Polym. Mater., 2020, 2, 4222
DOI: 10.1021/acsapm.0c00672

Enhanced β-Amyloid Aggregation in Living Cells Imaged with Quinolinium-Based Spontaneous Blinking Fluorophores

Hua Liu, Yingmei Cao, Yanan Deng, Lin Wei, Jinwu Yan and Lehui Xiao

Chemical & Biomedical Imaging, 2024, 2, 56
DOI: 10.1021/cbmi.3c00081

Advances in neural stem cells in aging and age-related neurodegenerative diseases

Rujia Zhong, Wenhao Huang, Chao Chen, Baorong Zhang, Jiali Pu and Feng Zhang

Ageing Neur Dis., 2025, 5
DOI: 10.20517/and.2024.32

Occurrence of Biased Conformations as Precursors of Assembly States in Fibril Elongation of Amyloid-β Fibril Variants: An In Silico Study

Rafael B. Frigori, Fernando L. Barroso da Silva, Patrícia P. D. Carvalho and Nelson A. Alves

J. Phys. Chem. B, 2020, 124, 2798
DOI: 10.1021/acs.jpcb.0c01360

Unveiling the Effects of Copper Ions in the Aggregation of Amyloidogenic Proteins

Valentina Oliveri

Molecules, 2023, 28, 6446
DOI: 10.3390/molecules28186446

Hydrophilicity-Driven Modulation of Amyloid-β(1–40) Fibrillation by Engineered Nanomaterials

Xuecheng Yang, Xiaoyu Zhang, Ge Yu, Yubin Ma, Xin Li, Yiyang Guo, Shuping Wang, Dan Ge, Changying Xue, Kun Jin and Bingbing Sun

ACS Appl. Mater. Interfaces, 2025, 17, 56631
DOI: 10.1021/acsami.5c12708

Preparation of Tetradentate Copper Chelators as Potential Anti‐Alzheimer Agents

Weixin Zhang, Daya Huang, Meijie Huang, Ju Huang, Dean Wang, Xingguo Liu, Michel Nguyen, Laure Vendier, Serge Mazères, Anne Robert, Yan Liu and Bernard Meunier

ChemMedChem, 2018, 13, 684
DOI: 10.1002/cmdc.201700734

Excited-State Intramolecular Hydrogen Transfer of Compact Molecules Controls Amyloid Aggregation Profiles

Mannkyu Hong, Mingeun Kim, Jiwon Yoon, Seung-Hee Lee, Mu-Hyun Baik and Mi Hee Lim

JACS Au, 2022, 2, 2001
DOI: 10.1021/jacsau.2c00281

Hybrid Bis-Histidine Phenanthroline-Based Ligands to Lessen Aβ-Bound Cu ROS Production: An Illustration of Cu(I) Significance

Marielle Drommi, Clément Rulmont, Charlène Esmieu and Christelle Hureau

Molecules, 2021, 26, 7630
DOI: 10.3390/molecules26247630

Antiamyloidogenic Chemical/Biochemical-Based Designed Nanoparticle as Artificial Chaperone for Efficient Inhibition of Protein Aggregation

Nibedita Pradhan, Koushik Debnath, Suman Mandal, Nihar R. Jana and Nikhil R. Jana

Biomacromolecules, 2018, 19, 1721
DOI: 10.1021/acs.biomac.8b00671

Competitive homo- and hetero- self-assembly of amyloid-β 1–42 and 1–40 in the early stage of fibrillation

Chae Eun Heo, Tae Su Choi and Hugh I. Kim

International Journal of Mass Spectrometry, 2018, 428, 15
DOI: 10.1016/j.ijms.2018.02.002

Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?

Mara Mather

Seminars in Cell & Developmental Biology, 2021, 116, 108
DOI: 10.1016/j.semcdb.2021.05.013

Optimization of quinolinium-carbazole theranostics for the improved photooxidation of β-amyloid aggregates with the variation of conjugation site

Zhiyu Xie, Chenwei Hu, Yanping Li, Lei Zhang and Jinwu Yan

Journal of Photochemistry and Photobiology A: Chemistry, 2024, 456, 115823
DOI: 10.1016/j.jphotochem.2024.115823

High‐affinity multivalent interactions between apolipoprotein E and the oligomers of amyloid‐β

Shamasree Ghosh, Timir Baran Sil, Subhrajyoti Dolai and Kanchan Garai

The FEBS Journal, 2019, 286, 4737
DOI: 10.1111/febs.14988

Multifunctional Carbon-Dot-Photosensitizer Nanoassemblies for Inhibiting Amyloid Aggregates, Suppressing Microbial Infection, and Overcoming the Blood–Brain Barrier

Chaoren Yan, Chaoli Wang, Xu Shao, Yonggang Teng, Peng Chen, Xiaoling Hu, Ping Guan and Hong Wu

ACS Appl. Mater. Interfaces, 2022, 14, 47432
DOI: 10.1021/acsami.2c14118

γ-Glutamylcysteine attenuates amyloid-β oligomers-induced neuroinflammation in microglia via blocking NF-κB signaling pathway

Aijing Bi, Yanan Wang, Luyao Chen, Zhimin Yin and Lan Luo

Chemico-Biological Interactions, 2022, 363, 110019
DOI: 10.1016/j.cbi.2022.110019

An integrated strategy to correlate aggregation state, structure and toxicity of Aß 1–42 oligomers

Federica Bisceglia, Antonino Natalello, Melania Maria Serafini, Raffaella Colombo, Laura Verga, Cristina Lanni and Ersilia De Lorenzi

Talanta, 2018, 188, 17
DOI: 10.1016/j.talanta.2018.05.062

APP‐C31: An Intracellular Promoter of Both Metal‐Free and Metal‐Bound Amyloid‐β40 Aggregation and Toxicity in Alzheimer's Disease

Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyeon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han, Mu‐Hyun Baik, Young‐Ho Lee and Mi Hee Lim

Advanced Science, 2024, 11
DOI: 10.1002/advs.202307182

α‐O‐Glycosylation at Tyrosine 10 Promotes the Astrocyte Clearance of Amyloid‐β Peptide 1–42

Lu Huang, Dangliang Liu, Qijia Wei, Changdong He, Jun Zhang and Suwei Dong

ChemBioChem, 2026, 27
DOI: 10.1002/cbic.202500459

Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis

Zhihui Yin, Xinyue Geng, Zhengyi Zhang, Ying Wang and Xiaoyan Gao

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.746711

Alzheimer’s Disease Immunotherapy: Current Strategies and Future Prospects

Ali Aljassabi, Tarek Zieneldien, Janice Kim, Deepika Regmi and Chuanhai Cao

Journal of Alzheimer’s Disease, 2024, 98, 755
DOI: 10.3233/JAD-231163

Oligomeric Protein Complexes Formed by Beta Amyloid Peptides and Their Molecular Associates

Hsiang‐Ting Lee, Han‐Wen Chang, Yeh‐Tung Lin, Shing‐Jong Huang, Meng‐Hsin Wu, Chang‐Shun Tsai, Ling‐Hsien Tu, Ming‐Che Lee, Yun‐Ru Chen and Jerry Chun Chung Chan

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202501099

Photomodulating Carbon Dots for Spatiotemporal Suppression of Alzheimer’s β-Amyloid Aggregation

You Jung Chung, Chang Heon Lee, Jinyeong Lim, Jinhyeong Jang, Hyuno Kang and Chan Beum Park

ACS Nano, 2020, 14, 16973
DOI: 10.1021/acsnano.0c06078

Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer’s Disease

Axel Abelein, Simone Ciofi-Baffoni, Cecilia Mörman, Rakesh Kumar, Andrea Giachetti, Mario Piccioli and Henrik Biverstål

JACS Au, 2022, 2, 2571
DOI: 10.1021/jacsau.2c00438

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Sofia Söllvander, Elisabeth Nikitidou, Linn Gallasch, Marlena Zyśk, Linda Söderberg, Dag Sehlin, Lars Lannfelt and Anna Erlandsson

J Neuroinflammation, 2018, 15
DOI: 10.1186/s12974-018-1134-4

Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants

Nathalie Grova, Henri Schroeder, Jean-Luc Olivier and Jonathan D. Turner

International Journal of Genomics, 2019, 2019, 1
DOI: 10.1155/2019/2085496

Molecular simulations of amyloid beta assemblies

Gianvito Grasso and Andrea Danani

Advances in Physics: X, 2020, 5, 1770627
DOI: 10.1080/23746149.2020.1770627

Synthesis and mechanistic investigation of short peptides as Aβ aggregation inhibitors

Rajesh Parmar, Naina Sehra, Indresh K. Maurya, Vinod Kumar, Kulbhushan Tikoo and Rahul Jain

Bioorganic Chemistry, 2025, 163, 108756
DOI: 10.1016/j.bioorg.2025.108756

Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation

Jong-Min Suh, Gunhee Kim, Juhye Kang and Mi Hee Lim

Inorg. Chem., 2019, 58, 8
DOI: 10.1021/acs.inorgchem.8b02813

The Effects of A21G Mutation on Transmembrane Amyloid Beta (11–40) Trimer: An In Silico Study

Son Tung Ngo, Minh Tung Nguyen, Nguyen Thanh Nguyen and Van V. Vu

J. Phys. Chem. B, 2017, 121, 8467
DOI: 10.1021/acs.jpcb.7b05906

Aβ42 Double Mutant Inhibits Aβ42-Induced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells

Ofek Oren, Shani Ben Zichri, Ran Taube, Raz Jelinek and Niv Papo

ACS Chem. Neurosci., 2020, 11, 1027
DOI: 10.1021/acschemneuro.9b00638

Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia

Mingeun Kim, Juhye Kang, Misun Lee, Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Jiyong Park, Soo Jin Oh, Ji-Yoon Lee, Joo-Yong Lee, Mu-Hyun Baik and Mi Hee Lim

J. Am. Chem. Soc., 2020, 142, 8183
DOI: 10.1021/jacs.9b13100

Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation

Xinrui Gui, Shuang Feng, Zilong Li, Yanyan Li, Bernd Reif, Bingyang Shi and Zheng Niu

Journal of Biological Chemistry, 2023, 299, 102926
DOI: 10.1016/j.jbc.2023.102926

Tuning Structures and Properties for Developing Novel Chemical Tools toward Distinct Pathogenic Elements in Alzheimer’s Disease

Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Shin Jung C. Lee, Jong-Min Suh, Jaeheung Cho, Junghyun Chae and Mi Hee Lim

ACS Chem. Neurosci., 2018, 9, 800
DOI: 10.1021/acschemneuro.7b00454

Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process

Shun Hu, Changwen Yang, Yanqing Li, Qingming Luo and Haiming Luo

Biosensors and Bioelectronics, 2022, 199, 113881
DOI: 10.1016/j.bios.2021.113881

DNA-based nanostructures for cell membrane receptor regulation and disease treatment

Zhongyu Cheng, Yanfei Liu, Qiwen Chen, Yifu Tan, Yunqi Man, Zhirou Zhang, Shuqing Du, Zexiang Lv, Qian Wang, Kan Shao and Zhenbao Liu

Advanced Drug Delivery Reviews, 2025, 225, 115674
DOI: 10.1016/j.addr.2025.115674

Dual-Emission GFP Chromophore-Based Derivative for Imaging and Discriminating Aβ Oligomers and Aggregates

Huaxiang Leng, Yuxuan Wang, Juan Wang, Han Sun, Anyang Sun, Marco Pistolozzi, Lei Zhang and Jinwu Yan

Anal. Chem., 2022, 94, 1999
DOI: 10.1021/acs.analchem.1c03452

Hydroxylated Single-Walled Carbon Nanotubes Inhibit Aβ42 Fibrillogenesis, Disaggregate Mature Fibrils, and Protect against Aβ42-Induced Cytotoxicity

Fufeng Liu, Wenjuan Wang, Jingcheng Sang, Longgang Jia and Fuping Lu

ACS Chem. Neurosci., 2019, 10, 588
DOI: 10.1021/acschemneuro.8b00441

The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins

Carmelo Tempra, Carmelo La Rosa and Fabio Lolicato

Chemistry and Physics of Lipids, 2021, 236, 105061
DOI: 10.1016/j.chemphyslip.2021.105061

Advances of metallodrug-amyloid β aggregation inhibitors for therapeutic intervention in neurodegenerative diseases: Evaluation of their mechanistic insights and neurotoxicity

Huzaifa Yasir Khan, Azeem Ahmad, Md Nadir Hassan, Yassir Hasan Khan, Farukh Arjmand and Rizwan Hasan Khan

Coordination Chemistry Reviews, 2024, 501, 215580
DOI: 10.1016/j.ccr.2023.215580

The Other Side of Alzheimer’s Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers

Chiara Argentati, Ilaria Tortorella, Martina Bazzucchi, Carla Emiliani, Francesco Morena and Sabata Martino

JPM, 2020, 10, 115
DOI: 10.3390/jpm10030115

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

Masha G. Savelieff, Geewoo Nam, Juhye Kang, Hyuck Jin Lee, Misun Lee and Mi Hee Lim

Chem. Rev., 2019, 119, 1221
DOI: 10.1021/acs.chemrev.8b00138

MicroRNA-455–5p/CPEB1 pathway mediates Aβ-related learning and memory deficits in a mouse model of Alzheimer’s disease

Gelei Xiao, Qianwei Chen and Xuewei Zhang

Brain Research Bulletin, 2021, 177, 282
DOI: 10.1016/j.brainresbull.2021.10.008

Molecular interactions, structural effects, and binding affinities between silver ions (Ag+) and amyloid beta (Aβ) peptides

Amanda L. Lakela, Elina Berntsson, Faraz Vosough, Jüri Jarvet, Suman Paul, Andreas Barth, Astrid Gräslund, Per M. Roos and Sebastian K. T. S. Wärmländer

Sci Rep, 2025, 15
DOI: 10.1038/s41598-024-59826-6

Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology

Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani and Satyabrata Kar

Bioactive Materials, 2022, 17, 506
DOI: 10.1016/j.bioactmat.2022.05.030

Elevated Plasma Oligomeric Amyloid β-42 Is Associated with Cognitive Impairments in Cerebral Small Vessel Disease

Wensheng Qu, Liding Zhang, Xiaohan Liang, Zhiyuan Yu, Hao Huang, Jing Zhao, Yinping Guo, Xirui Zhou, Shabei Xu, Haiming Luo and Xiang Luo

Biosensors, 2023, 13, 110
DOI: 10.3390/bios13010110

Alzheimer Hastalığı ve Anti-Alzheimer Etkili Bileşiklerin Yapılarının Araştırılması

Özden TARI and Ramazan YAĞMURTAŞAN

HUJPHARM, 2023
DOI: 10.52794/hujpharm.1175099

The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

Na Liu, Miao-Miao Lin and Yan Wang

Mol Neurobiol, 2023, 60, 247
DOI: 10.1007/s12035-022-03063-3

Amyloid by Design: Intrinsic Regulation of Microbial Amyloid Assembly

Maya Deshmukh, Margery L. Evans and Matthew R. Chapman

Journal of Molecular Biology, 2018, 430, 3631
DOI: 10.1016/j.jmb.2018.07.007

Molecular recognition of amyloid-β oligomers in Alzheimer's disease

Muhammad Jehangir, Xindi Xia, Cheng Wang, Ming Hu and Xiaohui Wang

Microchemical Journal, 2025, 218, 115298
DOI: 10.1016/j.microc.2025.115298

Fight Aβ Aggregation with Molecular Aggregates

Cheng Wang, Dingxin Zhang, Ming Hu and Xiaohui Wang

Macro Chemistry & Physics, 2025, 226
DOI: 10.1002/macp.202400531

DEAD‐Box Helicase 6 Blockade in Brain‐Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity

Xiaoxu Wang, Lu Dai, Na Wu, Donghui Wu, Xinyuan Wang, Xia Meng, Qilei Zhang, Jing Lu, Xiaoxin Yan, Jing Zhang and Baian Chen

MedComm, 2025, 6
DOI: 10.1002/mco2.70156

Curcumin Complex Analogues as Near-Infrared Fluorescent Probes for Monitoring all Aβ Species in the Early Alzheimer’s Disease Model

Yiran Ge, Fantian Zeng, Gaofeng Sun, Kewen Peng, Xiao Li, Huijuan Yu, Chao Cheng, Yungen Xu and Jian Yang

ACS Chem. Neurosci., 2021, 12, 3683
DOI: 10.1021/acschemneuro.1c00419

A mechanistic survey of Alzheimer's disease

Yijing Tang, Dong Zhang, Xiong Gong and Jie Zheng

Biophysical Chemistry, 2022, 281, 106735
DOI: 10.1016/j.bpc.2021.106735

Probing the interactions between amyloidogenic proteins and bio-membranes

Liang Ma, Xi Li, Robert B. Petersen, Anlin Peng and Kun Huang

Biophysical Chemistry, 2023, 296, 106984
DOI: 10.1016/j.bpc.2023.106984

Discovery of novel 5-(2-hydroxyphenyl)-2-phthalide-3(3H)-pyrazolones as balanced multifunctional agents against Alzheimer's disease

Shiqin Cong, Yichun Shi, Guangjun Yu, Feng Zhong, Jingjing Li, Jing Liu, Chanyuan Ye, Zhenghuai Tan and Yong Deng

European Journal of Medicinal Chemistry, 2023, 250, 115216
DOI: 10.1016/j.ejmech.2023.115216

Spectroscopic investigations on metal coordination to amyloid‐β

Mingeun Kim and Mi Hee Lim

Bulletin Korean Chem Soc, 2025, 46, 1066
DOI: 10.1002/bkcs.70085

Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers

Fantian Zeng, Jian Yang, Xiaofang Li, Kewen Peng, Chongzhao Ran, Yungen Xu and Yuyan Li

Bioorganic & Medicinal Chemistry, 2020, 28, 115559
DOI: 10.1016/j.bmc.2020.115559

Synthesis and effects of flavonoid structure variation on amyloid-β aggregation

Ana M. Matos, Joana S. Cristóvão, Dmitry V. Yashunsky, Nikolay E. Nifantiev, Ana S. Viana, Cláudio M. Gomes and Amélia P. Rauter

Pure and Applied Chemistry, 2017, 89, 1305
DOI: 10.1515/pac-2017-0201

Activating autophagy to eliminate toxic protein aggregates with small molecules in neurodegenerative diseases

Yuqi Fu, Jin Zhang, Rui Qin, Yueting Ren, Tingting Zhou, Bo Han and Bo Liu

Pharmacological Reviews, 2025, 77, 100053
DOI: 10.1016/j.pharmr.2025.100053

Modeling structural interconversion in Alzheimers’ amyloid beta peptide with classical and intrinsically disordered protein force fields

Kingsley Y. Wu, David Doan, Marco Medrano and Chia-en A. Chang

Journal of Biomolecular Structure and Dynamics, 2022, 40, 10005
DOI: 10.1080/07391102.2021.1939163

Altered synaptic currents, mitophagy, mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention

Binbin Zhao, Dongfeng Wei, Qinghua Long, Qingjie Chen, Fushun Wang, Linlin Chen, Zefei Li, Tong Li, Tao Ma, Wei Liu, Linshuang Wang, Caishui Yang, Xiaxia Zhang, Ping Wang and Zhanjun Zhang

Journal of Pharmaceutical Analysis, 2024, 14, 348
DOI: 10.1016/j.jpha.2023.10.006

Structural analysis of copper(I) interaction with amyloid β peptide

Giuseppe De Gregorio, Francesco Biasotto, Aleksandra Hecel, Marek Luczkowski, Henryk Kozlowski and Daniela Valensin

Journal of Inorganic Biochemistry, 2019, 195, 31
DOI: 10.1016/j.jinorgbio.2019.03.006

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile and Roberta Cascella

Alz Res Therapy, 2024, 16
DOI: 10.1186/s13195-023-01361-z

Anti-CLEC7A nanobody in situ engineering promotes amyloid-β oligomers clearance by CAR-microglia to alleviate Alzheimer's disease pathology in mice

Chongzheng Yan, Zhichao Kong, Yuxue Pan, Zhipeng Fu, Kun Han, Xiaotian Zhao, Jing Zhang, Longyu Bo, Weiyi Sun, Jinxin Gao, Xianghui Dong, Zuolin Zheng, Xiao Yue, Peng Sun, Xinyi Jiang and Chen Chen

Journal of Controlled Release, 2026, 392, 114710
DOI: 10.1016/j.jconrel.2026.114710