Trifluoromethylated cyclic-ADP-ribose mimic: synthesis of 8-trifluoromethyl-N1-[(5′′-O-phosphorylethoxy)methyl]-5′-O-phosphorylinosine-5′,5′′-cyclic pyrophosphate (8-CF3-cIDPRE) and its calcium release activity in T cells

Min Dong, Tanja Kirchberger, Xiangchen Huang, Zhen Jun Yang, Liang Ren Zhang, Andreas H. Guse and Li He Zhang

Org. Biomol. Chem., 2010, 8, 4705
DOI: 10.1039/c0ob00090f

Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor

Christelle Moreau, Gloria A. Ashamu, Victoria C. Bailey, Antony Galione, Andreas H. Guse and Barry V. L. Potter

Org. Biomol. Chem., 2011, 9, 278
DOI: 10.1039/C0OB00396D

Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca2+-mobilizing activity in T-lymphocytes

Lingjun Li, Cornelia C. Siebrands, Zhenjun Yang, Liangren Zhang, Andreas H. Guse and Lihe Zhang

Org. Biomol. Chem., 2010, 8, 1843
DOI: 10.1039/b925295a

A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge

N. Qi, K. Jung, M. Wang, L. X. Na, Z. J. Yang, L. R. Zhang, A. H. Guse and L. H. Zhang

Chem. Commun., 2011, 47, 9462
DOI: 10.1039/c1cc13062e

Pyridine nucleotides and calcium signalling in arterial smooth muscle: From cell physiology to pharmacology

A. Mark Evans, Christopher N. Wyatt, Nicholas P. Kinnear, Jill H. Clark and Elisa A. Blanco

Pharmacology & Therapeutics, 2005, 107, 286
DOI: 10.1016/j.pharmthera.2005.03.003

Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii

Connie M.C. Lam, Patrick K.K. Yeung, Hon Cheung Lee and Joseph T.Y. Wong

Cell Calcium, 2009, 45, 346
DOI: 10.1016/j.ceca.2008.12.006

Variable-Temperature NMR Spectroscopy, Conformational Analysis, and Thermodynamic Parameters of Cyclic Adenosine 5′-Diphosphate Ribose Agonists and Antagonists

Sarah-Marie Saatori, Tanner J. Perez and Steven M. Graham

J. Org. Chem., 2018, 83, 2554
DOI: 10.1021/acs.joc.7b02749

cADPR Does Not Activate TRPM2

Winnie Maria Riekehr, Simon Sander, Jelena Pick, Henning Tidow, Andreas Bauche, Andreas H. Guse and Ralf Fliegert

IJMS, 2022, 23, 3163
DOI: 10.3390/ijms23063163

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Joanna M. Watt, Mark P. Thomas and Barry V. L. Potter

Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-33484-x

Synthesis of 7-Deaza-cyclic Adenosine-5′-diphosphate-carbocyclic-ribose and Its 7-Bromo Derivative as Intracellular Ca2+-Mobilizing Agents

Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Takashi Sakurai, Hayato Fukuda, Mitsuhiro Arisawa and Satoshi Shuto

J. Org. Chem., 2015, 80, 6619
DOI: 10.1021/acs.joc.5b00723

Cyclic ADP-Carbocyclic-Ribose and -4-Thioribose, as Stable Mimics of Cyclic ADP-Ribose, a Ca²⁺-Mobilizing Second Messenger

Satoshi Shuto

Chem. Pharm. Bull., 2018, 66, 155
DOI: 10.1248/cpb.c17-00668

Cellular effects and metabolic stability of N1‐cyclic inosine diphosphoribose and its derivatives

T Kirchberger, G Wagner, J Xu, C Cordiglieri, P Wang, A Gasser, R Fliegert, S Bruhn, A Flügel, F E Lund, L‐h Zhang, B V L Potter and A H Guse

British J Pharmacology, 2006, 149, 337
DOI: 10.1038/sj.bjp.0706869

25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca2+ Mobilizing Second Messengers Together with Professor Barry Potter

Andreas H. Guse

Molecules, 2020, 25, 4220
DOI: 10.3390/molecules25184220

A solid-phase approach to the synthesis of N-1-alkyl analogues of cyclic inosine-diphosphate-ribose (cIDPR)

Giorgia Oliviero, Stefano D'Errico, Nicola Borbone, Jussara Amato, Vincenzo Piccialli, Michela Varra, Gennaro Piccialli and Luciano Mayol

Tetrahedron, 2010, 66, 1931
DOI: 10.1016/j.tet.2010.01.013

Synthesis of cyclic N1-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells

Ahmed Mahal, Stefano D’Errico, Nicola Borbone, Brunella Pinto, Agnese Secondo, Valeria Costantino, Valentina Tedeschi, Giorgia Oliviero, Vincenzo Piccialli and Gennaro Piccialli

Beilstein J. Org. Chem., 2015, 11, 2689
DOI: 10.3762/bjoc.11.289

Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal

HongMin Zhang, Richard Graeff, Zhe Chen, LiangRen Zhang, LiHe Zhang, HonCheung Lee and Quan Hao

Journal of Molecular Biology, 2011, 405, 1070
DOI: 10.1016/j.jmb.2010.11.044

A concise route for the preparation of nucleobase-simplified cADPR mimics by click chemistry

Lingjun Li, Baichuan Lin, Zhenjun Yang, Liangren Zhang and Lihe Zhang

Tetrahedron Letters, 2008, 49, 4491
DOI: 10.1016/j.tetlet.2008.05.076

Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)

Andreas H. Guse

The FEBS Journal, 2005, 272, 4590
DOI: 10.1111/j.1742-4658.2005.04863.x

Cyclic Adenosine 5′-Diphosphoribose (cADPR) Mimics Used as Molecular Probes in Cell Signaling

Liangren Zhang, Jianbo Yue and Li-He Zhang

The Chemical Record, 2015, 15, 511
DOI: 10.1002/tcr.201402072

The evolving chemistry of cADPR analogues: from marine discovery to calcium signaling tools

Andrea Patrizia Falanga, Ahmed Mahal, Maria Marzano, Stefano D'Errico, Agnese Secondo, Ilaria Piccialli and Nicola Borbone

Bioorganic Chemistry, 2025, 166, 109055
DOI: 10.1016/j.bioorg.2025.109055

Design and synthesis of 4″,6″-unsaturated cyclic ADP-carbocyclic-ribose, a Ca2+-mobilizing agent selectively active in T cells

Takashi Kudoh, Takashi Murayama, Minako Hashii, Haruhiro Higashida, Takashi Sakurai, Clarisse Maechling, Bernard Spiess, Karin Weber, Andreas H. Guse, Barry V.L. Potter, Mitsuhiro Arisawa, Akira Matsuda and Satoshi Shuto

Tetrahedron, 2008, 64, 9754
DOI: 10.1016/j.tet.2008.07.068

Aberrant Cyclization Affords a C-6 Modified Cyclic Adenosine 5′-Diphosphoribose Analogue with Biological Activity in Jurkat T Cells

Christelle Moreau, Tanja Kirchberger, Bo Zhang, Mark P. Thomas, Karin Weber, Andreas H. Guse and Barry V. L. Potter

J. Med. Chem., 2012, 55, 1478
DOI: 10.1021/jm201127y

First Enzymatic Synthesis of an N1‐Cyclized cADPR (Cyclic‐ADP Ribose) Analogue with a Hypoxanthine Partial Structure: Discovery of a Membrane Permeant cADPR Agonist.

Gerd K. Wagner, Steven Black, Andreas H. Guse and Barry V. L. Potter

ChemInform, 2003, 34
DOI: 10.1002/chin.200346201

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38

Joanna M. Swarbrick, Richard Graeff, Hongmin Zhang, Mark P. Thomas, Quan Hao and Barry V. L. Potter

J. Med. Chem., 2014, 57, 8517
DOI: 10.1021/jm501037u

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Joanna M. Watt, Richard Graeff and Barry V. L. Potter

Molecules, 2021, 26, 7165
DOI: 10.3390/molecules26237165

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

Tanja Kirchberger, Christelle Moreau, Gerd K. Wagner, Ralf Fliegert, Cornelia C. Siebrands, Merle Nebel, Frederike Schmid, Angelika Harneit, Francesca Odoardi, Alexander Flügel, Barry V. L. Potter and Andreas H. Guse

Biochemical Journal, 2009, 422, 139
DOI: 10.1042/BJ20082308

A Minimal Structural Analogue of Cyclic ADP-ribose

Andreas H. Guse, Xianfeng Gu, Liangren Zhang, Karin Weber, Elisabeth Krämer, Zhenjun Yang, Hongwei Jin, Qin Li, Lucie Carrier and Lihe Zhang

Journal of Biological Chemistry, 2005, 280, 15952
DOI: 10.1074/jbc.M414032200

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Christelle Moreau, Qun Liu, Richard Graeff, Gerd K. Wagner, Mark P. Thomas, Joanna M. Swarbrick, Satoshi Shuto, Hon Cheung Lee, Quan Hao, Barry V. L. Potter and Eugene A. Permyakov

PLoS ONE, 2013, 8, e66247
DOI: 10.1371/journal.pone.0066247

2′-Deoxy Cyclic Adenosine 5′-Diphosphate Ribose Derivatives: Importance of the 2′-Hydroxyl Motif for the Antagonistic Activity of 8-Substituted cADPR Derivatives

Bo Zhang, Gerd K. Wagner, Karin Weber, Clive Garnham, Anthony J. Morgan, Antony Galione, Andreas H. Guse and Barry V. L. Potter

J. Med. Chem., 2008, 51, 1623
DOI: 10.1021/jm7010386

Synthesis and use of cell-permeant cyclic ADP-ribose

Daniel Rosen, Duncan Bloor-Young, James Squires, Raman Parkesh, Gareth Waters, Sridhar R. Vasudevan, Alexander M. Lewis and Grant C. Churchill

Biochemical and Biophysical Research Communications, 2012, 418, 353
DOI: 10.1016/j.bbrc.2012.01.025

Investigating cADPR and NAADP in intact and broken cell preparations

Anthony J. Morgan and Antony Galione

Methods, 2008, 46, 194
DOI: 10.1016/j.ymeth.2008.09.013

Total Synthesis of a Cyclic Adenosine 5′-Diphosphate Ribose Receptor Agonist

Joanna M. Swarbrick and Barry V. L. Potter

J. Org. Chem., 2012, 77, 4191
DOI: 10.1021/jo202319f