Issue 16, 2024

Hydrogen therapy: recent advances and emerging materials

Abstract

Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO, has emerged as a pivotal pathophysiological modulator with antioxidant, anti-inflammatory, and antiapoptotic attributes. Hydrogen therapy has been extensively studied both preclinically and clinically, especially in diseases with an inflammatory nature. Despite the substantial progress, challenges persist in achieving high hydrogen concentrations in target lesions, especially in cancer treatment. A notable breakthrough lies in water/acid reactive materials, offering enhanced hydrogen generation and sustained release potential. However, limitations include hydrogen termination upon material depletion and reduced bioavailability at targeted lesions. To overcome these challenges, catalytic materials like photocatalytic and sonocatalytic materials have surfaced as promising solutions. With enhanced permeability and retention effects, these materials exhibit targeted delivery and sustained stimuli-reactive hydrogen release. The future of hydrogen therapy hinges on continuous exploration and modification of catalytic materials. Researchers are urged to prioritize improved catalytic efficiency, enhanced lesion targeting effects, and heightened biosafety and biocompatibility in future development.

Graphical abstract: Hydrogen therapy: recent advances and emerging materials

Article information

Article type
Review Article
Submitted
28 3 2024
Accepted
30 6 2024
First published
05 7 2024

Biomater. Sci., 2024,12, 4136-4154

Hydrogen therapy: recent advances and emerging materials

Z. Jiang, M. Ainiwaer, J. Liu, B. Ying, F. Luo and X. Sun, Biomater. Sci., 2024, 12, 4136 DOI: 10.1039/D4BM00446A

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