Issue 20, 2023

Palladium-catalyzed highly chemoselective dearomative spirocyclization of Ugi adducts: facile access to functionalized benzoazepinespiroindolenines with diastereoselectivity

Abstract

An efficient palladium-catalyzed post-Ugi dearomative cyclization has been achieved, enabling the rapid assembly of diverse benzoazepinespiroindolenine derivatives with excellent chemoselectivity and good diastereoselectivity. This methodology can controllably introduce functionality and complexity into the dearomatized alicyclic products in a cost-effective and step-economical manner with a wide range of substrate scope. The highly precise dearomatization of complex Ugi adducts opens the door to address formidable chemoselectivity issues among nucleophilic sites, and complements the functional group compatibility of the classical dearomatization protocols. Density functional theory (DFT) calculations shed light on the reaction mechanism as well as the origin of chemoselectivity.

Graphical abstract: Palladium-catalyzed highly chemoselective dearomative spirocyclization of Ugi adducts: facile access to functionalized benzoazepinespiroindolenines with diastereoselectivity

Supplementary files

Article information

Article type
Research Article
Submitted
08 8 2023
Accepted
09 9 2023
First published
11 9 2023

Org. Chem. Front., 2023,10, 5083-5091

Palladium-catalyzed highly chemoselective dearomative spirocyclization of Ugi adducts: facile access to functionalized benzoazepinespiroindolenines with diastereoselectivity

C. Qu, S. Li, J. Liu, D. Tang, Z. Xu, Z. Chen and G. Song, Org. Chem. Front., 2023, 10, 5083 DOI: 10.1039/D3QO01262J

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