Issue 83, 2023

Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity

Abstract

Supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery. In this study, four novel biotin-linked calix[4]arenes BPCA1-BPCA4 have been rationally designed to construct nano-complex with doxorubicin. The in vitro and in vivo assessments reveal that BPCA4-DOX with excellent stability are capable of affording significantly superior anti-tumor activity and lower side effects.

Graphical abstract: Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity

Supplementary files

Article information

Article type
Communication
Submitted
24 8 2023
Accepted
18 9 2023
First published
19 9 2023

Chem. Commun., 2023,59, 12487-12490

Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity

D. Du, Y. Liu, J. Lan, X. Hou, J. Liu, Q. Shi, Q. Huang, Y. Xue, C. Yan and L. An, Chem. Commun., 2023, 59, 12487 DOI: 10.1039/D3CC04102F

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