Issue 1, 2018

Modelling oral up-take of hydrophobic and super-hydrophobic chemicals in fish

Abstract

We have extended a recently published toxicokinetic model for fish (TK-fish) towards the oral up-take of contaminants. Validation with hydrophobic chemicals revealed that diffusive transport through aqueous boundary layers in the gastro-intestinal tract and in the blood is the limiting process. This process can only be modelled correctly if facilitated transport by albumin or bile micelles through these boundary layers is accounted for. In a case study we have investigated the up-take of a super hydrophobic chemical, Dechlorane Plus. Our results suggest that there is no indication of a hydrophobicity or size cut-off in the bioconcentration of this chemical. Based on an extremely high, but mechanistically sound facilitation factor we received model results in good agreement with experimental values from the literature. The results also indicate that established experimental procedures for BCF determination cannot cover the very slow up-take and clearance kinetics that are to be expected for such a chemical.

Graphical abstract: Modelling oral up-take of hydrophobic and super-hydrophobic chemicals in fish

Supplementary files

Article information

Article type
Paper
Submitted
18 10 2017
Accepted
06 12 2017
First published
06 12 2017

Environ. Sci.: Processes Impacts, 2018,20, 98-104

Modelling oral up-take of hydrophobic and super-hydrophobic chemicals in fish

W. Larisch and K. Goss, Environ. Sci.: Processes Impacts, 2018, 20, 98 DOI: 10.1039/C7EM00495H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements