Issue 48, 2016

Macrolactam analogues of macrolide natural products

Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.

Graphical abstract: Macrolactam analogues of macrolide natural products

Article information

Article type
Review Article
Submitted
03 10 2016
Accepted
27 10 2016
First published
27 10 2016

Org. Biomol. Chem., 2016,14, 11301-11316

Macrolactam analogues of macrolide natural products

H. M. Hügel, A. T. Smith and M. A. Rizzacasa, Org. Biomol. Chem., 2016, 14, 11301 DOI: 10.1039/C6OB02149B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements