Issue 6, 2015

Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

Abstract

A convenient and efficient synthetic method for the construction of morpholine and piperazine derivatives in moderate to good yields was established. The reaction proceeds smoothly with 1.0 mol% gold catalyst loading. A plausible mechanism involving the cascade cyclization and isomerizations to produce the six-membered ring was proposed and supported by deuterium labeling experiments.

Graphical abstract: Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

Supplementary files

Article information

Article type
Research Article
Submitted
16 2 2015
Accepted
10 4 2015
First published
20 4 2015

Org. Chem. Front., 2015,2, 721-725

Author version available

Synthesis of morpholine or piperazine derivatives through gold-catalyzed cyclization reactions of alkynylamines or alkynylalcohols

L. Yao, Y. Wang and K. Huang, Org. Chem. Front., 2015, 2, 721 DOI: 10.1039/C5QO00060B

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