Issue 60, 2013

Storable palladacycles for selective functionalization of alkyne-containing proteins

Abstract

We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

Graphical abstract: Storable palladacycles for selective functionalization of alkyne-containing proteins

Supplementary files

Article information

Article type
Communication
Submitted
10 5 2013
Accepted
03 6 2013
First published
03 6 2013

Chem. Commun., 2013,49, 6809-6811

Storable palladacycles for selective functionalization of alkyne-containing proteins

G. Cheng, R. K. V. Lim, N. Li and Q. Lin, Chem. Commun., 2013, 49, 6809 DOI: 10.1039/C3CC43479F

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