Issue 62, 2013
From the journal:

Chemical Communications

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound†

Louise E. Wedlock,ab   Matt R. Kilburn,b   Rong Liu,b   Jeremy A. Shaw,b   Susan J. Berners-Price*ac  and  Nicholas P. Farrell*ad  

* Corresponding authors

a Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia
E-mail: s.berners-price@griffith.edu.au
Tel: +61 7 3735 7290

b Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Crawley, Australia

c School of Chemistry and Biochemistry, University of Western Australia, 35 Stirling Highway, Crawley, Australia

d Department of Chemistry, Virginia Commonwealth University Richmond, Virginia, USA
E-mail: npfarrell@vcu.edu

Abstract

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of 195Pt and 15N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

Graphical abstract: NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

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Article information

DOI
https://doi.org/10.1039/C3CC42098A
Article type
Communication
Submitted
22 3 2013
Accepted
07 5 2013
First published
09 5 2013

Chem. Commun., 2013,49, 6944-6946

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NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

L. E. Wedlock, M. R. Kilburn, R. Liu, J. A. Shaw, S. J. Berners-Price and N. P. Farrell, Chem. Commun., 2013, 49, 6944 DOI: 10.1039/C3CC42098A

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