From the journal:

Chemical Communications

Asymmetric Kinetic Resolution Polymerization of Racemic O-Carboxyanhydride Catalyzed by Cinchona Alkaloids

Yanju Jia,   Rulin Yang,   Hongguang Sun,   Xuanhua Guo,   Guangqiang Xu  and  Qinggang Wang  

Abstract

The enantioselective ring-opening polymerization of O-carboxyanhydride (OCA) has been demonstrated for the first time. Utilizing a cinchona alkaloid derivative featuring a confined chiral pocket, the asymmetric kinetic resolution polymerization (AKRP) of racemic OCA was achieved with a kinetic resolution coefficient (krel) up to 9.0, expanding the application scope of AKRP.

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DOI
https://doi.org/10.1039/D5CC05378A
Article type
Communication
Submitted
18 Sep 2025
Accepted
28 Oct 2025
First published
30 Oct 2025
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2025, Accepted Manuscript

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Asymmetric Kinetic Resolution Polymerization of Racemic O-Carboxyanhydride Catalyzed by Cinchona Alkaloids

Y. Jia, R. Yang, H. Sun, X. Guo, G. Xu and Q. Wang, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC05378A

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