A thiazolo[5,4-d]thiazole-bridged dinuclear iridium(III) photosensitizer induces ferroptosis for boosting photoimmunotherapy against hypoxic melanoma

Abstract

Incorporation of a thiazolo[5,4-d]thiazole moiety into a dinuclear Ir(III) complex yields a novel Type I/II photosensitizer. Upon irradiation, this dinuclear complex generates substantial reactive oxygen species, triggering ferroptosis and subsequent immunogenic cell death (ICD). This design enables potent hypoxic melanoma ablation concurrent with ICD signal induction.