Issue 2, 2024

A review of electrochemical impedance as a tool for examining cell biology and subcellular mechanisms: merits, limits, and future prospects

Abstract

Herein the development of cellular impedance biosensors, electrochemical impedance spectroscopy, and the general principles and terms associated with the cell–electrode interface is reviewed. This family of techniques provides quantitative and sensitive information into cell responses to stimuli in real-time with high temporal resolution. The applications of cell-based impedance biosensors as a readout in cell biology is illustrated with a diverse range of examples. The current state of the field, its limitations, the possible available solutions, and the potential benefits of developing biosensors are discussed.

Graphical abstract: A review of electrochemical impedance as a tool for examining cell biology and subcellular mechanisms: merits, limits, and future prospects

Article information

Article type
Critical Review
Submitted
18 8 2023
Accepted
22 11 2023
First published
23 11 2023

Analyst, 2024,149, 269-289

A review of electrochemical impedance as a tool for examining cell biology and subcellular mechanisms: merits, limits, and future prospects

S. Arman, R. D. Tilley and J. J. Gooding, Analyst, 2024, 149, 269 DOI: 10.1039/D3AN01423A

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