Issue 14, 2023

Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

Abstract

Photodynamic therapy (PDT) has attracted a great deal of attention in the field of cancer treatment due to its non-invasive nature, high repeatability and minimal side effects. Due to the dual effect of organic small molecule donors and platinum receptors, supramolecular coordination complexes (SCCs) exhibit stronger reactive oxygen species (ROS) production capacity and have become a promising class of photosensitizers (PSs). Herein, we report a rhomboid SCC MD-CN based on the D–A structure with aggregation-induced emission (AIE). The results show that the as-prepared nanoparticles (NPs) had excellent photosensitization efficiency and good biocompatibility. Most importantly, they exhibited potential killing effects on cancer cells in vitro under light irradiation.

Graphical abstract: Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
30 11 2022
Accepted
16 3 2023
First published
24 3 2023

Dalton Trans., 2023,52, 4296-4302

Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

H. Jia, T. Shi, T. He, Y. Li and S. Yin, Dalton Trans., 2023, 52, 4296 DOI: 10.1039/D2DT03855B

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