Issue 15, 2023

Asymmetric arene hydrogenation: towards sustainability and application

Abstract

(Hetero)aromatic compounds are vastly available and easy to functionalise building blocks in the chemical industry. Asymmetric arene hydrogenation enables direct access to complex three-dimensional scaffolds with (multiple) defined stereocentres in a single catalytic process and, by this, the rapid installation of molecular complexity. The potential usage of hydrogen from renewable sources and perfect atom economy bears the potential for sustainable and broadly applicable transformations to valuable products. The aim of this review is to present the state-of-the-art in transition-metal catalysed asymmetric hydrogenation of (hetero)arenes, to highlight recent advances and important trends and to provide a broad overview for the reader.

Graphical abstract: Asymmetric arene hydrogenation: towards sustainability and application

Article information

Article type
Review Article
Submitted
01 5 2023
First published
10 7 2023
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2023,52, 4996-5012

Asymmetric arene hydrogenation: towards sustainability and application

L. Lückemeier, M. Pierau and F. Glorius, Chem. Soc. Rev., 2023, 52, 4996 DOI: 10.1039/D3CS00329A

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