Issue 4, 2023

Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

Abstract

DNA-based electrochemical sensors use redox reporters to transduce affinity events into electrical currents. Ideally, such reporters must be electrochemically reversible, chemically stable for thousands of redox cycles, and tolerant to changing chemical environments. Here we report the first use of an Os(II/III) complex in DNA-based sensors, which undergoes pH-insensitive electron transfer with 35% better operational stability relative to the benchmark methylene blue, making it a promising reporter for continuous molecular monitoring applications where pH fluctuates with time.

Graphical abstract: Os(ii/iii) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

Supplementary files

Article information

Article type
Paper
Submitted
20 11 2022
Accepted
04 1 2023
First published
05 1 2023
This article is Open Access
Creative Commons BY-NC license

Analyst, 2023,148, 806-813

Os(II/III) complex supports pH-insensitive electrochemical DNA-based sensing with superior operational stability than the benchmark methylene blue reporter

M. Aller Pellitero, N. Kundu, J. Sczepanski and N. Arroyo-Currás, Analyst, 2023, 148, 806 DOI: 10.1039/D2AN01901A

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