Issue 7, 2022

A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy

Abstract

Photodynamic therapy (PDT) has been extensively studied as a noninvasive treatment option; however, the current PDT agents are often restricted with poor solubility, difficult accumulation in tumor sites, low singlet oxygen yield and low penetration depth. Herein we develop a one-/two-photon excitation [Pd4Ir8]16+ supramolecular cage (MOC-53) comprising multiple Ir(III) metalloligands, which can be quickly taken up by cancer cells to locate in the mitochondria with an ultra-high singlet oxygen generation efficiency (0.84). In particular, MOC-53 also exhibits singlet oxygen generation capability under two-photon excitation to enhance the depth of penetration and reduce photo-damage. JC-1 assays, Annexin V-FITC/PI assays and the activity of caspase-3/7 analyses show that MOC-53 can activate apoptosis efficiently. The tumor volume growth of mice after the intra-tumoral injection of MOC-53 is obviously restrained under the two-photon irradiation, showing a potential opportunity for photodynamic cancer treatment.

Graphical abstract: A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy

Supplementary files

Article information

Article type
Research Article
Submitted
03 12 2021
Accepted
21 2 2022
First published
24 2 2022

Mater. Chem. Front., 2022,6, 948-955

A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy

Y. Liu, H. Yu, Y. Wang, C. Li, X. Wang, C. Ye, H. Yao, M. Pan and C. Su, Mater. Chem. Front., 2022, 6, 948 DOI: 10.1039/D1QM01578H

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