Issue 6, 2022

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

Abstract

The design of 3D printable bio-based hydrogels with enhanced mechanical properties and minimal chemical modification can open new opportunities in the field of biomedical applications. A facile and safe approach is proposed to prepare mechanically reinforced chitosan-based hydrogels via a phenolated polyelectrolyte complex (PHEC) and enzyme-mediated crosslinking. PHEC was formed between phenolated chitosan and alginate, leading to the formation of in situ phenol-functionalized microfibers that exhibited excellent 3D printability. The synergistic complexation enhanced the loss modulus (60 times), toughness, flexibility, and moldability of hydrogel as well as dynamic viscosity (20 times) of the hydrogel precursor compared to individual phenolated chitosan and alginate hydrogels. This complexation endowed the material with excellent printability without sacrificing the hydrogel's elasticity. This study proposes a strategy to design tough and 3D printable marine-based hydrogels based on the synergistic complexation of a phenolated polyelectrolyte complex and enzyme-mediated crosslinking.

Graphical abstract: Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

Supplementary files

Article information

Article type
Paper
Submitted
22 11 2021
Accepted
05 1 2022
First published
05 1 2022

Green Chem., 2022,24, 2409-2422

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

H. Jafari, C. Delporte, K. V. Bernaerts, H. Alimoradi, L. Nie, D. Podstawczyk, K. C. Tam and A. Shavandi, Green Chem., 2022, 24, 2409 DOI: 10.1039/D1GC04347A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements