Issue 67, 2022

Directional migration propensity of calf thymus DNA in a gradient of metal ions

Abstract

Herein we report the migrational behaviour and spatial distribution of calf thymus DNA in a gradient of different physiologically relevant monovalent and divalent cations under two different conditions – (i) microfluidic and (ii) evaporating droplets. Amplified phoresis toward high concentrations of Mg2+ and Ca2+ compared to other ions and non-uniform DNA coating in a gradient of ions were observed. This process, which was governed by the effective charge and diffusion coefficient of the DNA–metal ion complex, can have potential applications in nucleic acid-based spatiotemporal surface patterning, biosensors, and dynamic biocolloidal assembly and transport.

Graphical abstract: Directional migration propensity of calf thymus DNA in a gradient of metal ions

Supplementary files

Article information

Article type
Communication
Submitted
04 6 2022
Accepted
18 7 2022
First published
18 7 2022

Chem. Commun., 2022,58, 9353-9356

Directional migration propensity of calf thymus DNA in a gradient of metal ions

Shikha, E. Shandilya, Priyanka and S. Maiti, Chem. Commun., 2022, 58, 9353 DOI: 10.1039/D2CC03160D

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