Issue 31, 2021

New antimicrobial self-assembling short lipopeptides

Abstract

Lipopeptides are an exceptional example of amphiphilic molecules that self-assemble into functional structures with applications in the areas of nanotechnology, catalysis or medicinal chemistry. Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization and antimicrobial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.

Graphical abstract: New antimicrobial self-assembling short lipopeptides

Supplementary files

Article information

Article type
Communication
Submitted
24 6 2021
Accepted
16 7 2021
First published
16 7 2021
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2021,19, 6797-6803

New antimicrobial self-assembling short lipopeptides

C. Vicente-García and I. Colomer, Org. Biomol. Chem., 2021, 19, 6797 DOI: 10.1039/D1OB01227D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements