Issue 16, 2021

Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles

Abstract

The transformation of the piroxicam monohydrate to form I or form II could be achieved precisely by adjusting the particle size itself in a 99% acetone-1% H2O solvent at 31 °C. Mechanistic studies have demonstrated that the particle size could affect both the maximum concentration of piroxicam and the heterogeneous nucleation of form II during the solution-mediated phase transformation (SMPT) process, finally determining the polymorph outcome.

Graphical abstract: Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles

Supplementary files

Article information

Article type
Communication
Submitted
18 2 2021
Accepted
20 3 2021
First published
22 3 2021

CrystEngComm, 2021,23, 2928-2932

Size-dependent solution-mediated phase transformation of piroxicam monohydrate particles

C. Yao, L. Wang, X. Wang and X. Tao, CrystEngComm, 2021, 23, 2928 DOI: 10.1039/D1CE00237F

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