Issue 18, 2021

Solubility improvement of curcumin with amino acids

Abstract

Curcumin (CUR) is used as a dietary and food supplement with medicinal properties. It has a wide range of therapeutic activities such as antioxidant, anti-inflammatory, anti-arthritis, anti-tumor, anti-hyperglycemic, anti-malarial, anti-bacterial, and antiviral properties. The low solubility of curcumin in aqueous medium (7.8 μg mL−1) and low bioavailability leads to its lack of use as an oral medicine. In this work, the use of basic amino acids and their biological derivatives to improve the physicochemical properties of curcumin is described. Binary adducts of CUR with tyramine, tryptamine, arginine, asparagine, glutamine, lysine, histidine, and citrulline were characterized by spectroscopic, thermal, X-ray and microscopic techniques. The solubility and dissolution of curcumin in 40% ethanol–water solution exhibited a considerable improvement for these binary products. The use of amino acids as additives to improve the solubility of CUR in medical supplements is described.

Graphical abstract: Solubility improvement of curcumin with amino acids

Supplementary files

Article information

Article type
Paper
Submitted
03 2 2021
Accepted
27 3 2021
First published
29 3 2021

CrystEngComm, 2021,23, 3398-3410

Solubility improvement of curcumin with amino acids

A. Gunnam and A. K. Nangia, CrystEngComm, 2021, 23, 3398 DOI: 10.1039/D1CE00171J

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