Issue 2, 2021

Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases

Abstract

For most antimicrobial compounds with intracellular targets, getting inside the cell is the major obstacle limiting their activity. To pass this barrier some antibiotics mimic the compounds of specific interest for the microbe (siderophores, peptides, carbohydrates, etc.) and hijack the transport systems involved in their active uptake followed by the release of a toxic warhead inside the cell. In this review, we summarize the information about the structures, biosynthesis, and transport of natural inhibitors of aminoacyl-tRNA synthetases (albomycin, microcin C-related compounds, and agrocin 84) that rely on such “Trojan horse” strategy to enter the cell. In addition, we provide new data on the composition and distribution of biosynthetic gene clusters reminiscent of those coding for known Trojan horse aminoacyl-tRNA synthetases inhibitors. The products of these clusters are likely new antimicrobials that warrant further investigation.

Graphical abstract: Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases

Supplementary files

Article information

Article type
Review Article
Submitted
16 11 2020
Accepted
10 2 2021
First published
22 2 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 468-485

Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases

D. Y. Travin, K. Severinov and S. Dubiley, RSC Chem. Biol., 2021, 2, 468 DOI: 10.1039/D0CB00208A

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