Issue 2, 2021

Advances in single-cell multi-omics profiling

Abstract

Single-cell profiling methods are developed to dissect heterogeneity of cell populations. Recently, multiple enzymatic or chemical treatments have been integrated into single-cell multi-omics profiling methods with high compatibility. These methods have been verified to identify rare or new cell types with high confidence. Single-cell multi-omics analysis can also provide tools to solve the complex regulatory network associated with genome coding, epigenome regulation, and transcripotome expression in a single cell. However, acquiring high-quality single-cell data still faces inherent technical challenges, and co-assays with some other layers of cell identify such as transcription factors binding, histone modifications etc., profiles need new technological breakthroughs to facilitate a more thorough understanding of a single cell. In this review, we summarize the recent advances of single-cell multi-omics methods and discuss the challenges and opportunities in this filed.

Graphical abstract: Advances in single-cell multi-omics profiling

Article information

Article type
Review Article
Submitted
04 9 2020
Accepted
10 1 2021
First published
20 1 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 441-449

Advances in single-cell multi-omics profiling

D. Bai, J. Peng and C. Yi, RSC Chem. Biol., 2021, 2, 441 DOI: 10.1039/D0CB00163E

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