Issue 47, 2020

Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy

Abstract

In the past decade, selective C–C and C-heteroatom bond construction through palladium-catalyzed direct C–H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)–H and C(sp3)–H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C–H bond functionalization via the directing group strategy.

Graphical abstract: Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy

Article information

Article type
Minireview
Submitted
31 5 2020
Accepted
08 7 2020
First published
09 7 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 12616-12632

Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy

K. Yang, M. Song, H. Liu and H. Ge, Chem. Sci., 2020, 11, 12616 DOI: 10.1039/D0SC03052J

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