Issue 39, 2020

Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans

Abstract

Glycosaminoglycans (GAGs) are biomacromolecules necessary for the regulation of different biological functions. In medicine, GAGs are important commercial therapeutics widely used for the treatment of thrombosis, inflammation, osteoarthritis and wound healing. However, protocols for the encapsulation of GAGs in MOFs carriers are not yet available. Here, we successfully encapsulated GAG-based clinical drugs (heparin, hyaluronic acid, chondroitin sulfate, dermatan sulfate) and two new biotherapeutics in preclinical stage (GM-1111 and HepSYL proteoglycan) in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The resultant GAG@MOF biocomposites present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which influences the drug-release kinetics upon applying an acidic stimulus. For a selected system, heparin@MOF, the released therapeutic retained its antithrombotic activity while the MOF shell effectively protects the drug from heparin lyase. By using different MOF shells, the present approach enables the preparation of GAG-based biocomposites with tunable properties such as encapsulation efficiency, protection and release.

Graphical abstract: Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans

Supplementary files

Article information

Article type
Edge Article
Submitted
28 2 2020
Accepted
11 7 2020
First published
14 7 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 10835-10843

Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans

M. D. J. Velásquez-Hernández, E. Astria, S. Winkler, W. Liang, H. Wiltsche, A. Poddar, R. Shukla, G. Prestwich, J. Paderi, P. Salcedo-Abraira, H. Amenitsch, P. Horcajada, C. J. Doonan and P. Falcaro, Chem. Sci., 2020, 11, 10835 DOI: 10.1039/D0SC01204A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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