Issue 3, 2020

Matters of class: coming of age of class III and IV lanthipeptides

Abstract

Lanthipeptides belong to the superfamily of ribosomally-synthesized and posttranslationally-modified peptides (RiPPs). Despite the fact that they represent one of the longest known RiPP subfamilies, their youngest members, classes III and IV, have only been described more recently. Since then, a plethora of studies furthered the understanding of their biosynthesis. While there are commonalities between classes III and IV due to the similar domain architectures of their processing enzymes, there are also striking differences that allow their discrimination. In this concise review article, we summarize what is known about the underlying biosynthetic principles of these lanthipeptides and discuss open questions for future research.

Graphical abstract: Matters of class: coming of age of class III and IV lanthipeptides

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Article information

Article type
Review Article
Submitted
18 5 2020
Accepted
08 7 2020
First published
16 7 2020
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2020,1, 110-127

Matters of class: coming of age of class III and IV lanthipeptides

J. D. Hegemann and R. D. Süssmuth, RSC Chem. Biol., 2020, 1, 110 DOI: 10.1039/D0CB00073F

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