Issue 6, 2019

Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics

Abstract

With the risks associated with healthcare-associated infections and the rise of antibiotic resistant microorganisms, there is an important need to control the proliferation of these factors in hospitals, retirement homes and other institutions. This work explores the development and application of a novel class of sulfonamide-based quaternary ammonium antimicrobial coatings, anchored to commercially and clinically relevant material surfaces. Synthesized in high yields (60–97%), benzophenone-anchored antimicrobials were spray-coated and UV grafted onto plastic surfaces, while silane-anchored variants were adhered to select textiles via dip-coating. Surface modified samples were characterised by advancing contact angle, anionic dye staining, X-ray photoelectron spectroscopy and atomic force microscopy. After verifying coating quality through the above characterization methods, microbiological testing was performed on batch samples in conditions that simulate the natural inoculation of surfaces and objects (solid/air) and water containers (solid/liquid). Using the previously established Large Drop Inoculum (LDI) protocol at solid/air interfaces, all treated samples showed a full reduction (105–107 CFU) of viable Arthrobacter sp., S. aureus, and E. coli after 3 h of contact time. Additional testing of the walls of plastic LDPE vials treated with a UV-cured sulfonamide antimicrobial at a solid/liquid interface using the newly developed Large Reservoir Inoculum (LRI) protocol under static conditions revealed a complete kill (>106 reduction) of Gram-positive Arthrobacter sp., and a partial kill (>104 reduction) of Gram-negative E. coli within 24–48 h of contact.

Graphical abstract: Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics

Supplementary files

Article information

Article type
Paper
Submitted
11 12 2018
Accepted
13 1 2019
First published
23 1 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 3140-3150

Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics

A. Caschera, K. B. Mistry, J. Bedard, E. Ronan, M. A. Syed, A. U. Khan, A. J. Lough, G. Wolfaardt and D. A. Foucher, RSC Adv., 2019, 9, 3140 DOI: 10.1039/C8RA10173F

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