Issue 2, 2019

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Abstract

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

Graphical abstract: Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Supplementary files

Article information

Article type
Communication
Submitted
14 9 2018
Accepted
31 10 2018
First published
31 10 2018
This article is Open Access
Creative Commons BY-NC license

Mater. Horiz., 2019,6, 385-393

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Z. Liu, Y. Li, W. Li, W. Lian, M. Kemell, S. Hietala, P. Figueiredo, L. Li, E. Mäkilä, M. Ma, J. Salonen, J. T. Hirvonen, D. Liu, H. Zhang, X. Deng and H. A. Santos, Mater. Horiz., 2019, 6, 385 DOI: 10.1039/C8MH01145A

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