Issue 95, 2019

A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

Abstract

A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed. Gal-NIR shows ratiometric response to ONOO with high sensitivity and selectivity. Moreover, the probe can accurately target the hepatocyte, and thus is used for assessing drug-induced hepatotoxicity and its remediation by using hepatoprotective medicines in living cells and mice.

Graphical abstract: A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

Supplementary files

Article information

Article type
Communication
Submitted
09 9 2019
Accepted
04 11 2019
First published
12 11 2019

Chem. Commun., 2019,55, 14307-14310

A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

W. Jiang, Y. Li, W. Wang, Y. Zhao, J. Fei and C. Li, Chem. Commun., 2019, 55, 14307 DOI: 10.1039/C9CC07017F

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