Issue 79, 2019

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Abstract

Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. Here, we report the first total synthesis of verucopeptin via condensation of the depsipeptide core and the polyketide side chain unit including three branched methyl groups after the synthesis of each segment.

Graphical abstract: Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Supplementary files

Article information

Article type
Communication
Submitted
09 8 2019
Accepted
06 9 2019
First published
18 9 2019

Chem. Commun., 2019,55, 11956-11959

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

N. Takahashi, H. Hayashi, V. Poznaks and H. Kakeya, Chem. Commun., 2019, 55, 11956 DOI: 10.1039/C9CC06169J

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