Issue 73, 2019

Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity

Abstract

A highly selective lysosome-targeting NIR fluorescent probe (Lyso-SiR-2S) for HOCl was constructed based on Si-rhodamine B spirodithiolactone. This probe was very effectively employed to sense HOCl produced in various living cells and to visualize fluctuations of endogenous HOCl resulting from GEN-induced acute kidney injury in vivo for the first time.

Graphical abstract: Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity

Supplementary files

Article information

Article type
Communication
Submitted
20 6 2019
Accepted
14 8 2019
First published
16 8 2019

Chem. Commun., 2019,55, 10916-10919

Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity

J. Wang, D. Cheng, L. Zhu, P. Wang, H. Liu, M. Chen, L. Yuan and X. Zhang, Chem. Commun., 2019, 55, 10916 DOI: 10.1039/C9CC04736K

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