Issue 51, 2019

Versatile “on–off” biosensing of thrombin and miRNA based on Ag(i) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

Abstract

A novel biosensing platform based on the Ag(I) ion-enhanced or Ag nanocluster (NC)-quenched electrochemiluminescence (ECL) of CdSe quantum dots (QDs) was designed for versatile “on–off” assays of thrombin (TB) and miRNA, in which bipedal molecular machine (BMM)-triggered surface programmatic chain reaction (SPCR) coupled with mesoporous silica nanoparticle (MSN) multiple amplification is used to introduce plentiful QDs and Ag+ ions to significantly improve the ECL signal.

Graphical abstract: Versatile “on–off” biosensing of thrombin and miRNA based on Ag(i) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

Supplementary files

Article information

Article type
Communication
Submitted
26 4 2019
Accepted
28 5 2019
First published
06 6 2019

Chem. Commun., 2019,55, 7350-7353

Versatile “on–off” biosensing of thrombin and miRNA based on Ag(I) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

J. Ge, C. Li, Y. Zhao, X. Yu and G. Jie, Chem. Commun., 2019, 55, 7350 DOI: 10.1039/C9CC03235E

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