Issue 27, 2019

A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region

Abstract

A fluorescence turn-on probe for amyloid detection in the extreme near-infrared region (>750 nm) is a highly desirable technological evolution from the view point of potential in vivo applications. Herein, we report a molecular rotor-based amyloid sensor probe which, on binding to the insulin amyloid fibril, registers a large turn-on emission in the near-infrared region, and records an exceptionally large red-shifted emission wavelength of ∼770 nm along with a Stokes’ shift of ∼150 nm, the highest reported to date for any amyloid sensor probe, in the insulin fibril bound form, in the near-infrared region. Importantly, when bound to insulin fibrils, this probe also exhibits an exceptionally large red-shift of ∼120 nm in the absorption spectra, which enables the naked eye in vitro detection of amyloid fibrils.

Graphical abstract: A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region

Supplementary files

Article information

Article type
Communication
Submitted
15 2 2019
Accepted
04 3 2019
First published
05 3 2019

Chem. Commun., 2019,55, 3907-3910

A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region

N. H. Mudliar and P. K. Singh, Chem. Commun., 2019, 55, 3907 DOI: 10.1039/C9CC01262A

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