Issue 27, 2019

Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

Abstract

A novel DNA hydrogel-amplified versatile fluorescence platform combined with hybridization chain reaction (HCR) and DNA walking multiple amplification was developed for ultrasensitive detection of miRNA. The DNA hydrogel was loaded with large amounts of SYBR Green (SG) I dyes or CdTe quantum dots (QDs) to assemble versatile signal probes.

Graphical abstract: Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

Supplementary files

Article information

Article type
Communication
Submitted
22 1 2019
Accepted
06 3 2019
First published
14 3 2019

Chem. Commun., 2019,55, 3919-3922

Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

C. Li, H. Li, J. Ge and G. Jie, Chem. Commun., 2019, 55, 3919 DOI: 10.1039/C9CC00565J

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