Issue 17, 2019

Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Abstract

The microviscosity change associated with reticulophagy is an important component for studying endoplasmic reticulum (ER) stress disorders. Here, a BODIPY-arsenicate conjugate 1-based fluorescent molecular rotor was designed to covalently bind vicinal dithiol-containing proteins in the ER, exhibiting a bifunction of reticulophagy initiation and microviscosity evaluation. Therefore, we could quantify the local viscosity changes during reticulophagy based on the fluorescence lifetime changes of probe 1.

Graphical abstract: Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Supplementary files

Article information

Article type
Communication
Submitted
13 1 2019
Accepted
29 1 2019
First published
30 1 2019

Chem. Commun., 2019,55, 2453-2456

Dual-functional fluorescent molecular rotor for endoplasmic reticulum microviscosity imaging during reticulophagy

Y. He, J. Shin, W. Gong, P. Das, J. Qu, Z. Yang, W. Liu, C. Kang, J. Qu and J. S. Kim, Chem. Commun., 2019, 55, 2453 DOI: 10.1039/C9CC00300B

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