Issue 12, 2018

Engaging sulfinate salts via Ni/photoredox dual catalysis enables facile Csp2–SO2R coupling

Abstract

This report details the development and implementation of a strategy to construct aryl- and heteroaryl sulfones via Ni/photoredox dual catalysis. Using aryl sulfinate salts, the C–S bond can be forged at room temperature under base-free conditions. An array of aryl- and heteroaryl halides are compatible with this approach. The broad tolerance and mild nature of the described reaction could potentially be employed to prepare sulfones with biological relevance (e.g., in bioconjugation, drug substance synthesis, etc.) as demonstrated in the synthesis of drug-like compounds or their precursors. When paired with existing Ni/photoredox chemistry for Csp3–Csp2 cross-coupling, an array of diverse sulfone scaffolds can be readily assembled from bifunctional electrophiles. A mechanistic manifold consistent with experimental and computational data is presented.

Graphical abstract: Engaging sulfinate salts via Ni/photoredox dual catalysis enables facile Csp2–SO2R coupling

Supplementary files

Article information

Article type
Edge Article
Submitted
21 12 2017
Accepted
21 2 2018
First published
22 2 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2018,9, 3186-3191

Engaging sulfinate salts via Ni/photoredox dual catalysis enables facile Csp2–SO2R coupling

M. J. Cabrera-Afonso, Z. Lu, C. B. Kelly, S. B. Lang, R. Dykstra, O. Gutierrez and G. A. Molander, Chem. Sci., 2018, 9, 3186 DOI: 10.1039/C7SC05402E

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