Issue 16, 2018

Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Abstract

In this study, a soft salt complex based photosensitizer has been developed for photodynamic therapy (PDT) of cancer cells. The iridium(III) complex [Ir(L)(L′)]3+(PF6)3 (C1) with L and L′ being terpyridine ligands (L = 4′-phenyl-2,2′:6′,2′′-terpyridine, L′ = 3-([2,2′:6′,2′′-terpyridin]-4′-yl)-9-hexyl-9H-carbazole) was chosen as the cationic component, and the iridium(III) complex [Ir(dfppy)2CN2]Bu4N+ (A1) was selected as the anionic component. Complexes C1 and A1 are directly connected through electrostatic interaction to form a soft salt based photosensitizer (S1), which exhibited an enhanced singlet oxygen generation rate because of efficient energy transfer between two ionic metal complexes. Furthermore, this novel photosensitizer was successfully applied in photodynamic therapy (PDT) of cancer cells for the first time.

Graphical abstract: Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Supplementary files

Article information

Article type
Paper
Submitted
23 2 2018
Accepted
16 3 2018
First published
16 3 2018

Dalton Trans., 2018,47, 5582-5588

Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Y. Ma, S. Zhang, H. Wei, Y. Dong, L. Shen, S. Liu, Q. Zhao, L. Liu and W. Wong, Dalton Trans., 2018, 47, 5582 DOI: 10.1039/C8DT00720A

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