Issue 80, 2018

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

Abstract

An ESIPT-based ‘AND’ logic fluorescence probe (GSH-ABAH) was developed for the simultaneous detection of ONOO and biological thiols. GSH-ABAH was shown to have good cell permeability and with the addition of just SIN-1 (ONOO donor) or GSH, no fluorescence response was observed in live cells. However, in the presence of both analytes GSH-ABAH could be used to image exogenous ONOO ‘AND’ GSH added to RAW264.7 cells.

Graphical abstract: ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

Supplementary files

Article information

Article type
Communication
Submitted
25 8 2018
Accepted
11 9 2018
First published
11 9 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 11336-11339

ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

L. Wu, H. Han, L. Liu, J. E. Gardiner, A. C. Sedgwick, C. Huang, S. D. Bull, X. He and T. D. James, Chem. Commun., 2018, 54, 11336 DOI: 10.1039/C8CC06917D

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