Issue 50, 2018

Improving metabolome coverage and data quality: advancing metabolomics and lipidomics for biomarker discovery

Abstract

This Feature Article highlights some of the key challenges within the field of metabolomics and examines what role separation and analytical sciences can play to improve the use of metabolomics in biomarker discovery and personalized medicine. Recent progress in four key areas is highlighted: (i) improving metabolite coverage, (ii) developing accurate methods for unstable metabolites including in vivo global metabolomics methods, (iii) advancing inter-laboratory studies and reference materials and (iv) improving data quality, standardization and quality control of metabolomics studies.

Graphical abstract: Improving metabolome coverage and data quality: advancing metabolomics and lipidomics for biomarker discovery

Article information

Article type
Feature Article
Submitted
30 3 2018
Accepted
23 5 2018
First published
23 5 2018

Chem. Commun., 2018,54, 6728-6749

Improving metabolome coverage and data quality: advancing metabolomics and lipidomics for biomarker discovery

D. Vuckovic, Chem. Commun., 2018, 54, 6728 DOI: 10.1039/C8CC02592D

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