Issue 50, 2018

A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

Abstract

A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (−40 to 10 °C) was required.

Graphical abstract: A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

Supplementary files

Article information

Article type
Communication
Submitted
23 1 2018
Accepted
05 3 2018
First published
06 3 2018

Chem. Commun., 2018,54, 6804-6807

A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

M. Seo, S. Jang and H. Kim, Chem. Commun., 2018, 54, 6804 DOI: 10.1039/C8CC00574E

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