Issue 4, 2017

Sensing telomerase: From in vitro detection to in vivo imaging

Abstract

Telomerase is a ribonucleoprotein reverse transcriptase that is responsible for maintaining the telomere length in cells. Telomerase overexpresses in almost all malignant tumor cells, and it has become a promising biomarker and a potential therapy target for cancers. Consequently, accurate and efficient quantification of the telomerase is highly essential to medical diagnostics and therapeutics. Recently, a series of novel telomerase detection methods with excellent performance have been developed, but a overview of in vivo telomerase detection methods is lacking. In this Minireview, we summarize the emerging strategies for telomerase assays in the last five years, including both in vitro assays and in vivo imaging methods, and discuss their future directions as well.

Graphical abstract: Sensing telomerase: From in vitro detection to in vivo imaging

Article information

Article type
Minireview
Submitted
28 10 2016
Accepted
12 12 2016
First published
13 12 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 2495-2502

Sensing telomerase: From in vitro detection to in vivo imaging

L. Wang, F. Ma, B. Tang and C. Zhang, Chem. Sci., 2017, 8, 2495 DOI: 10.1039/C6SC04801C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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