Issue 60, 2017

Effect of metal–metal distance in Ni(ii)-based metallo-supramolecular polymers: DNA binding and cytotoxicity

Abstract

Two Ni(II)-based metallo-supramolecular polymers (polyNiL1 and polyNiL2) with different metal–metal distances were synthesized via (1 : 1) complexation between the Ni salts with bis(1,10-phenanthroline)s and their DNA binding properties and cytotoxicity were revealed. Short metal–metal distances (1.35 nm) in polyNiL2 showed ∼7 times stronger DNA binding properties and remarkably higher cytotoxicity to Hela-Fucci cells than long metal–metal distances (1.95 nm) in polyNiL1. Enhancement of Ni polymer-induced cell killing has been observed in a cell cycle study.

Graphical abstract: Effect of metal–metal distance in Ni(ii)-based metallo-supramolecular polymers: DNA binding and cytotoxicity

Supplementary files

Article information

Article type
Paper
Submitted
19 5 2017
Accepted
25 7 2017
First published
02 8 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 38008-38013

Effect of metal–metal distance in Ni(II)-based metallo-supramolecular polymers: DNA binding and cytotoxicity

Md. D. Hossain, U. Rana, C. Chakraborty, J. Li, R. Nagano, T. Minowa and M. Higuchi, RSC Adv., 2017, 7, 38008 DOI: 10.1039/C7RA05644C

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