Issue 54, 2017

1H and 19F NMR in drug stress testing: the case of voriconazole

Abstract

Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is required, other methods are needed. Arguably the most powerful method for determining chemical structure information is NMR spectroscopy. Here we show that NMR alone, using a combination of simple 19F, 1H, and DOSY experiments, can characterise both structure and kinetics of an intact reaction mixture, without the need for any physical separation.

Graphical abstract: 1H and 19F NMR in drug stress testing: the case of voriconazole

Supplementary files

Article information

Article type
Paper
Submitted
03 4 2017
Accepted
26 6 2017
First published
05 7 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 34000-34004

1 H and 19F NMR in drug stress testing: the case of voriconazole

T. M. Barbosa, G. A. Morris, M. Nilsson, R. Rittner and C. F. Tormena, RSC Adv., 2017, 7, 34000 DOI: 10.1039/C7RA03822D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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