Issue 2, 2017

Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

Abstract

Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary to obtain information about its mechanism using a carbon paste electrode (CPE) modified with chitosan (Cs)/multi-walled carbon nanotubes (CNT) and cobalt nanoparticles (CoNps). The simultaneous determination of DAC with the hepatitis B antiviral drug entecavir (ENT) was also investigated by differential pulse voltammetry in universal buffer pH 2.0. The experimental results specify a linear relation between the DAC peak current and its concentration in the range from 1.0 nM to 12 μM, leading to a detection limit of 8.82 × 10−10 M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.

Graphical abstract: Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

Article information

Article type
Paper
Submitted
25 10 2016
Accepted
28 11 2016
First published
04 1 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 1118-1126

Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

Shereen M. Azab and A. M. Fekry, RSC Adv., 2017, 7, 1118 DOI: 10.1039/C6RA25826C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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