Issue 6, 2017

Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

Abstract

Facile assembly of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide starting from anilines, N-arylacrylamides and DABCO·(SO2)2 is developed. This one-pot reaction proceeds efficiently in dichloroethane, leading to sulfonated oxindoles in good yields. Anilines serve as the aryl source, and the in situ generated sulfonyl radicals from sulfur dioxide as the key intermediates are trapped by N-arylacrylamides to provide the corresponding products. Additionally, a broad reaction scope is observed under mild conditions.

Graphical abstract: Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

Supplementary files

Article information

Article type
Research Article
Submitted
26 1 2017
Accepted
16 2 2017
First published
17 2 2017

Org. Chem. Front., 2017,4, 1079-1083

Synthesis of 3-((arylsulfonyl)methyl)indolin-2-ones via insertion of sulfur dioxide using anilines as the aryl source

T. Liu, D. Zheng and J. Wu, Org. Chem. Front., 2017, 4, 1079 DOI: 10.1039/C7QO00075H

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