Issue 5, 2017

Atom economical synthesis of N-alkylbenzamides via the iron(iii) sulfate catalyzed rearrangement of 2-alkyl-3-aryloxaziridines in water and in the presence of a surfactant

Abstract

A green and mild synthetic route to N-alkylbenzamides involves eco-friendly one pot synthesis of 2-alkyl-3-aryloxaziridines from N-alkylamines and benzaldehydes followed by iron(III) sulfate catalyzed rearrangement to the corresponding amides in water as the solvent and in the presence of sodium dodecyl sulfate as the surfactant. This green approach affords N-alkylbenzamides in high overall yields under simple and minimum manipulation.

Graphical abstract: Atom economical synthesis of N-alkylbenzamides via the iron(iii) sulfate catalyzed rearrangement of 2-alkyl-3-aryloxaziridines in water and in the presence of a surfactant

Supplementary files

Article information

Article type
Communication
Submitted
27 12 2016
Accepted
21 1 2017
First published
23 1 2017

Green Chem., 2017,19, 1263-1267

Atom economical synthesis of N-alkylbenzamides via the iron(III) sulfate catalyzed rearrangement of 2-alkyl-3-aryloxaziridines in water and in the presence of a surfactant

J. Kraïem and T. Ollevier, Green Chem., 2017, 19, 1263 DOI: 10.1039/C6GC03589B

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