Issue 45, 2017

Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

Abstract

We report an amidine-based small molecule two-photon fluorescent probe (ELP1) for monitoring vesicle transport from the ER to lysosome in live cells. Two-photon microscopy imaging studies indicated that this probe initially localized in the ER and subsequently transferred to lysosomal compartments through vesicular transport. These results may provide an effective tool for studying trafficking-related biology and pathology in real-time.

Graphical abstract: Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

Supplementary files

Article information

Article type
Communication
Submitted
27 2 2017
Accepted
15 5 2017
First published
15 5 2017

Chem. Commun., 2017,53, 6097-6100

Visualization of vesicular transport from the endoplasmic reticulum to lysosome using an amidine derived two-photon probe

H. W. Lee, M. K. Cho, H. Kim, C. S. Lim, C. Kang and H. M. Kim, Chem. Commun., 2017, 53, 6097 DOI: 10.1039/C7CC01518F

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